Dr. Murphy's laboratory is interdisciplinary with strong collaborative ties to the schools of Medicine, Veterinary Medicine and Engineering. He has four areas of research ongoing in his laboratories: 1) The modulation of cell behaviors and corneal wound healing by trophic factors, 2) The modulation of cell behaviors by topographic features of the substratum, 3) Comparative ocular functional morphology, 4) The development of improved solutions for organ storage prior to transplantation. The majority of his time spent on investigating how biophysical cues provided through the extracellular matrix modulate fundamental behaviors in diverse cell types.
D.V.M., Cornell University, New York City, New York, 1983
Ph.D., Cornell University, New York City, New York, 1984
B.S., Cornell University, Ithaca, New York, 1978
UC Davis School of Veterinary Medicine, Davis, California, 1987
Corneal Fellow, UC Davis, School of Medicine, Sacramento, California, 1989
American Association for the Advancement of Science
American Veterinary Medical Association
Association for Research in Vision and Ophthalmology
Diplomate, American College of Veterinary Ophthalmologists
Tear Film and Ocular Society
Honors and Awards
H. Talmage Dobbs Lectureship, Emory Eye Center, 2007
Commencement speaker, Class of 2007, School of Veterinary Medicine, UW-Madison, 2007
Pfizer Award for Outstanding Research, School of Veterinary Medicine, UW-Madison, 2006
Lifetime Career Achievement Award in Research, American Veterinary Medical Foundation, 2003
1St Cello Lecturer, UC Davis - Recognition of contributions to veterinary practice, 1999
11th Schalm Lecturer, UC Davis - Recognition of contributions to comparative ophthalmology, 1999
American College of Veterinary Ophthalmologists, Diplomate, 1989
Select Recent Publications
C. Kafarnik, C.J. Murphy, RR Dubielzig. Canine duplication of Descemet's membrane. Veterinary Pathology. 46:3,464-473. 2009.
D.R McFarlin, K.J. Finn, P.F. Nealey, C.J. Murphy. Nanoscale topography modulates human embryonic stem cell self-renewal. Journal of Biomimetics, Biomaterials, and Tissue Engineering. 2009, vol. 2. 15-26. 2009.
J.A Last, S.J. Liliensiek, P.F. Nealey, C.J. Murphy. Determining the mechanical properties of human corneal basement membranes with atomic force microscopy. J Struct Biol. Jul;167(1):19-24. 2009.
S.J. Liliensiek, P. Nealey, C.J. Murphy. Characterization of endothelial basement membrane nanotopography in rhesus macaque as a guide for vessel tissue engineering. Tissue Eng Part A Sep; 15(9):2643-51. 2009
S.S. Soofi, J.A Last, S.J. Liliensiek, P.F. Nealey, C.J. Murphy. The elastic modulus of Matrigel as determined by atomic force microscopy. J Struct Biol. Sep; 167(3):216-9. 2009.
Y.S. Kwon, J.D. Foley, P. Russell, J.F. McAnulty, C.J. Murphy. Prevention of cold ischemia/rewarming-induced ERK ~, p38 kinase and HO-1 activation by trophic factor supplementation of UW solution. Cryobiology. 57:72-74, 2008.
S.A Fraser, Y. Ting, AE. Wendt, C.J. Murphy, P.F. Nealey. Sub-micron and Nanoscale feature depth modulates alignment of stromal fibroblasts and corneal epithelial cells in serum-rich and serum-free media. Journal of Biomedical Materials Research. 86:725-735, 2008.
M.A Kubai, E. Bentley, P.E. Miller, D.O. Mutti, C.J. Murphy. Refractive states of eyes and association between ametropia and breed in dogs. American Journal of Veterinary Research. 69:946-951, 2008.
N.W. Karuri, P.F. Nealey, C.J. Murphy, RM. Albrecht. Structural organization of the cytoskeleton in SV40 human corneal epithelial cells cultured on nano- and microscale grooves. Scanning. 30(5):405-413, 2008.
P. Russell, J.Z. Gasiorowski, P.F. Nealey, C.J. Murphy. Response of human trabecular meshwork cells to topographic cues on the nanoscale level. Investigative Ophthalmology & Visual Science. 49:629-635, 2008.
R Carter, E. Bentley, R Kambampati, RJ. Erhardt, C.J. Murphy. Expression of Matrix Metalloproteinase 2 and 9 in Experimentally Wounded Canine Corneas and Spontaneous Chronic Corneal Epithelial Defects (SCCED). Cornea. 26 (10):1213-9, 2007.