Dr. Zhou’s research focus is in the differentiation of human adult and embryonic stem cells along a hepatocyte lineage and their use in liver repair and regeneration. Dr. Zhou is also interested in understanding the mechanisms that regulate hepatocyte fate selection.
Ph.D., Molecular Biology, University of Illinois at Chicago, Chicago IL 1999
B.S., Chongqing University of Medical Sciences, Chongqing/Sichuan China 1985
American Association for the Study of Liver Diseases
International Society for Stem Cell Research
Select Recent Publications
Magner P, Jung Y, Wu J, Nolta JA, Zern MA, Zhou P*. Insulin and IGFs enhance hepatocyte differentiation from human embryonic stem cells via the PI3K/AKT pathway. Stem Cells 2013, 31 (10), 2095-2103.
Guan M, Yao W, Liu R, Lam KS, Nolta J, Jia J, Panganiban B, Meng L, Zhou P, Shahnazari M, Ritchie RO, Lane NE. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nat. Med. 2012, 18 (3), 456-462.
Zhou P, Lessa N, Estrada DC, Severson EB, Lingala S, Zern MA, Nolta JA, Wu J. Decellularized liver matrix as a carrier for the transplantation of human fetal and primary hepatocytes in mice. Liver Transpl. 2011, 17 (4), 418-427.
Zhou P, Gross S, Liu JH, Yu BY, Feng LL, Nolta J, Sharma V, Piwnica-Worms D, Qiu SX. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. FASEB J. 2010 Dec;24(12):4722-32.
Zhou P, Hohm S, Olusanya Y, Hess D, Nolta J. Human progenitor cells with high aldehyde dehydrogenase activity efficiently engraft into damaged liver in a novel model. Hepatology 2009, 46(6): 1992-2000.