Yang Xiang, Ph.D.

Yang K. Xiang, Ph.D.

Specialties

Pharmacology

Department

Pharmacology

Title

  • Professor
Yang K. Xiang is not currently accepting new patients. For assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

Genome and Biomedical Sciences Building

451 Health Sciences Drive, Suite 3503
Davis, CA 95616
Driving Directions

Primary Phone:
530-752-3200

Additional Phone Numbers

Phone: 530-752-6895

Emails

Personal:
ykxiang@ucdavis.edu

Research/Academic Interests

My research focuses on signaling integration of a converged network of insulin receptor and adrenergic receptors, and their roles in different clinical conditions including diabetes, cardiovascular complication and Alzheimer’s disease, respectively.

We apply an arsenal of advanced approaches ranging from single molecular study and live cell imaging to in vivo manipulation and patient’s sample examination to understand physiology and pathophysiological roles of the receptors, and their implication in drug discovery and clinical therapy.

Education

Ph.D., Vollum Institute, Oregon Health Science University, Portland OR

B.S., Wuhan University, Wuhan, China

Professional Memberships

American Diabetes Association

American Heart Association

American Society for Pharmacology and Experimental Therapeutics

American Society of Biochemistry & Molecular Biology

Honors and Awards

American Heart Association Established Investigator, 2016

Select Recent Publications

Liu SB, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. Activation of the Gs-coupled EP receptor regulates the spatio-propagation of cAMP signal induced by the Gs-coupled βAR in animal hearts. PNAS. 2012;109(17):6578-83.

Jain A, Liu R, Xiang YK*, and Ha J*. Single molecular Pull-down for studying protein interactions. Nature Protocol. 2012;7: 445–452. * co-corresponding author.

Liu SB, Zhang J, and Xiang YK. FRET-based direct detection of PKA activity in sarcoplasmic reticulum in cardiac myocytes. BBRC. 2011;14;404(2):581-6.

Xiang YK. Spatiotemporal regulation of beta adrenergic signals in cardiomyocytes. Circulation Research. 2011;109(2):231-44.

Wang D, Yuen EY, Zhou Y, Yan Z and Xiang YK. Amyloid β induce internalization and degradation of β2 adrenergic receptor in prefrontal cortical neurons. J Biol Chem. 2011;286(36):31852-63.

Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang YK, Ha T.Probing cellular protein complexes using single-molecule pull-down. Nature. 2011 May 26;473(7348):484-8.