Mingyi Chen, M.D., Ph.D.
Pathology - Molecular
Pathology - Hematopathology
- Associate Professor
Dr. Chen's clinical interests include: Hematopathology- lymphoma, leukemia, flow cytometry, bone marrow transplant and diagnostic molecular pathology, Pulmonary pathology, and GI-liver pathology.
Dr. Chen's research interests include: Sickle cell disease, thrombosis, and vascular biology, Molecular pathogenesis of lymphoma and leukemia, tumor immunology and GVHD, Viral infections and cancergenesis.
M.D., Peking University Health Science Center, Beijing, China 1992
Ph.D., Kyoto University, Kyoto Japan 2001
Pathology and Lab Medicine, Loma Linda University Hospital, Loma Linda CA 2009
Pathology, City of Hope Medical Center, Duate CA 2010
American Board of Pathology, Anatomic and Clinical Pathology,
American Board of Pathology, Hematology,
American Society of Hematology
International Society for Laboratory Hematology
United States and Canadian Academy of Pathology
Honors and Awards
International Society Hematology Presentation Award, 2014
Faculty Teaching Award of Department of Pathology UC Davis Medical Center, 2013
Select Recent Publications
Mirsoian A, Boucklaka MN, Sckisel GD, Chen M, Pai CS, Maverakis,E, Spencer RG. Fishbein KF, Siddiqui S, Monjazeb AM, Martin B, Maudsley S, Longo DL, Blazar BR, Taub DD, and Murphy WJ. Adiposity as a Principal Component of Lethal Cytokine Storm Following Immunotherapy in Aged Mice. J Exp Med. 2014 Nov 17;211(12):2373-83.
Canter RJ, Ames E, Mac S, Grossenbacher SK, Chen M, Li CS, Borys D, Smith RC, Tellez J, Sayers TJ, Monjazeb AM, Murphy WJ. Anti-Proliferative but not Anti-Angiogenic Tyrosine Kinase Inhibitors Enrich for Cancer Stem Cells in Soft Tissue Sarcoma. BMC Cancer 2014 Oct 10;14(1):756.
Pai CC, Chen M, Mirsoian A, Grossenbacher SK, Tellez J, Ames E, Sun K, Blazar BR, Murphy WJ, Mehrdad A. Treatment of Chronic Graft versus Host Disease with Bortezomib. Blood. 2014 Sep 4;124(10):1677-88.
Pai CC, Hsiao HH, Sun K, Chen M, Hagino T, Tellez J, Mall C, Blazar BR, Monjazeb A, Abedi M, Murphy WJ. Therapeutic benefit of bortezomib on acute GVHD is tissue specific and is associated with IL-6 levels. Biol Blood Marrow Transplant. 2014 Jul 23. pii: S1083-8791(14)00448-50.
Alvarez M, Bouchlaka MN, Sckisel GD, Sungur CM, Chen M, Murphy WJ. J Immunol. 2014 Jul 7. pii: 1400034. Increased Antitumor Effects Using IL-2 with Anti-TGF-β Reveals Competition between Mouse NK and CD8 T Cells. J Immunol. 2014 Aug 15;193(4):1709-16.
Chen M, Abedi M. Atypical lymphocytosis and cold agglutinin hemolytic anemia associated with monoclonal gammopathy in HIV-infected patient with marrow involvement by diffuse large B-cell lymphoma. Blood, 2013 Nov 28;122(23):3711.
Chen M, Green R. Circulating plasma cells with Russell bodies in osteroslerotic myeloma. Blood 2013 122:160
Chen M, Olson K. Colonic graft-versus-host disease (GVHD) manifesting as eosinophilic colitis following autologous hematopoietic stem cell transplantation. Blood. 2013 May 16;121(20):4020.
Sungur CM, Tang-Feldman YJ, Ames E, Alvarez M, Chen M, Longo DL, Pomeroy C, Murphy WJ. Murine natural killer cell licensing and regulation by T regulatory cells in viral responses. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7401-6.
Bouchlaka M Sckisel G, Chen M,, Mirsoan A, Zamora A, Monjazeb A, Longo D, Blazar BR, Taub DD, Murphy WJ. Aging Predisposes to Acute Pro-inflammatory Cytokine Storm-Induced Pathologies Following Systemic Immune Stimulation. J Exp Med. 2013 Oct 21;210(11):2223-37.