Charles H. Halsted, M.D.
Gastroenterology and Hepatology
Endocrinology, Diabetes, and Metabolism
Philosophy of Care
I am trained and experienced in internal medicine with subspecialties of gastroenterology, hepatology, and clinical nutrition. I have more than 40 years of experience and unique insights into the diagnosis and treatment of intestinal disorders and their interactions with good nutritional status of my patients. In addition, I believe that patient education is essential to maintenance of good health and prevention of disease by proper diet and exercise and avoidance of smoking and alcohol abuse. Accurate diagnoses, compassionate personal relationships with my patients, and the ability to inspire trust are essential in developing effective treatment plans. The UC Davis Health System gives me the opportunity to provide this kind of care to my patients.
Charles H. Halsted is a recognized leader in clinical nutrition and gastroenterology. His clinical expertise includes evaluation and treatment of liver and intestinal diseases as well as nutritional diseases such as obesity, hyperlipidemias, chronic alcoholism, and folic acid and vitamin B-12 deficiencies. His research interests encompass the role of nutrition in health maintenance and disease prevention, the relationship of poor nutrition to chronic alcoholism, and intestinal malabsorption syndrome. Halsted has developed animal models for investigating nutritional metabolic consequences of prolonged ethanol consumption. He also is editor-in-chief of American Journal of Clinical Nutrition.
Endocrinology, Diabetes, and Metabolism
M.D., University of Rochester School of Medicine, Rochester, New York, 1962
B.A., Stanford University, Palo Alto, California, 1958
Cleveland Metropolitan General Hospital, Cleveland, Ohio, 1966
Johns Hopkins Hospital, Baltimore, Maryland, 1970
American Board of Internal Medicine, 1970
American Board of Internal Medicine, Gastroenterology and Hepatology, 1973
American Board of Nutrition, Specialist in Human and Clinical Nutrition, 1984
American Association for the Advancement of Science, Fellow
American Association for the Study of Liver Disease
American Clinical and Climatological Association
American College of Physicians, Fellow
American Federation of Clinical Research
American Gastroenterological Association, Fellow
American Society for Clinical Investigation
American Society for Nutrition Science, Fellow
Research Society on Alcoholism
Western Association of Physicians
Honors and Awards
Nutrition Educator Award, American Society for Clinical Nutrition, 1997
Joseph B. Goldberger Award, American Medical Association, 1992
Select Recent Publications
Esfandiaria F, Medici V, Jose S, Wong DH, Dolatshahi M, Quinlivan E, Dayal S, Lentz SR, Tsukamoto H, Zhang YH, French SW, Halsted CH. Epiggenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed Cystathionine Beta Synthase deficient mouse. Hepatology. 2010; 51:932-941
Medici V, Peerson JM, Stabler SP, French SW, Gregory III JF, Virata MC, Albanese A, Bowlus CL, Devaraj S, Panacek EA, Rahim N, Richards JR, Rossaro L, Halsted CH. Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. J Hepatol 2010; 53:551-557
Halsted CH, Levine MA, Lonnerdal BL and Rucker RB. Vitamins and Minerals. In: Yamada T, Alpers DH, Kalloo AN, Kaplowitz N, Owyang C and Powell DW. Textbook of Gastroenterology, 5th Edition. Wiley-blackwell, Chichester, U.K. 2009, pp.478-507.
Esfandiari F, Villanueva JA, Wong DH, You,M, French SW, Halsted CH. Sadenosylmethionine (SAM) attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate deficient diet. Alcoholism: Clinical and Experimental Research 2007; 31:1231-1239
Villanueva JA, Esfandiari F, White ME, Devaraj S, French SW, Halsted CH. Sadenosylmethionine (SAM) attenuates oxidative liver injury in micropigs fed ethanol with a folate deficient diet. Alcoholism: Clinical and Experimental Research 2007; 31:1934-1943.
Halsted CH, Wong DH, Peerson JM, Warden CH, Refsum H, Smith AD, Nygard OK, Ueland PM, Vollset SE, Tell GS. Relationships of Glutamate Carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine levels and cognition in a homogenous Norwegian population: The Hordoland Homocysteine Study. Amer J Clin Nutr 2007; 86:514-21.
Devlin AM, Clarke R, Birks J, Evans JG, Halsted CH. Interactions among polymorphisms in folate metabolizing genes and serum total homocysteine in a healthy elderly population. Amer J Clin Nutr 2006; 83:708-713
Esfandiari F, Villanueva JA., Wong D, French SW, Halsted CH. Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. American Journal of Physiology; Gastrointestinal and Liver Physiology. 2005; 289:G54-G63.
Villanueva JA, Halsted CH. Hepatic transmethylation reactions in micropigs with alcoholic liver disease. Hepatology 2004; 39:1303-1310
Halsted CH, Villanueva JA, Devlin AM, Parkkila S, Niemela 0, Garrow TA, Wallock LM, Shigenaga M, Melnyk S, James SJ. Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proceedings of the National Academy of Science 2002; 99:10072-10077