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Department of Internal Medicine

Carroll E. Cross, M.D. View profile as PDF

Carroll E. Cross

Philosophy of Care

In working with patients, I use a careful and efficient application of scientific knowledge to the artful practice of pulmonary medicine. I strongly believe that UC Davis makes a special contribution to the Sacramento-area community through the heartfelt concern of medical students, house staff and faculty for the health and welfare of the patients it serves.

Clinical Interests

Dr. Cross serves as co-director of UC Davis' Adult Cystic Fibrosis Clinic and also has a special interest in alpha-antitrypsin deficiency (congenital emphysema). He has produced over 200 publications on topics related to inhalation toxicology, with a focus on oxidants including ozone, oxides of nitrogen and cigarrette smoke, and antioxidant micronutrients. He also has published on several aspects of clinical lung disease.




Internal Medicine, Pulmonary and Critical Care


Internal Medicine


Pulmonary and Critical Care Medicine


UC Davis Medical Group - Sacramento (J Street)
Internal Medicine Specialty Clinics
2825 J St., Suite 400
Sacramento, CA 95816
Driving Directions
Phone: 916-734-2737

Additional Phone:

Physician Referrals: 800-4-UCDAVIS (800-482-3284)


M.D., Columbia University, College of Physicians and Surgeons, New York, New York, 1961
B.A., Pomona College, Claremont, California, 1957


University of Wisconsin Hospital Center, Madison, Wisconsin, 1961-1962


Stanford University, School of Medicine, Palo Alto, California, 1962-1964


University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, 1964-68

Board Certifications:

American Board of Internal Medicine, 1969
American Board of Internal Medicine, Pulmonary Disease, 1971

Professional Memberships:

American Federation for Clinical Research
American Physiological Society
American Thoracic Society
Biochemical Society
British Thoracic Society
The Society of Free Radicals in Biology and Medicine
Western Society of Physicians

Select Honors and Awards:

California Medal, 2000

Fulbright Fellowship, 1982

Select Recent Publications:

Morrissey, B.M., B.C. Schock, G.P. Marelich and C.E. Cross. Cystic fibrosis in adults: current and future management strategies. Clin Rev in Allergy & Immunol 25:275-288, 2004.

Reznick, A.Z., Klein, J.P. Eiserich, C.E. Cross and R.M. Nagler. Inhibition of oral peroxidase activity by cigarette smoke: in vivo and in vitro studies. Free Radical Biology & Medicine 34:377-384, 2003.

Valacchi, G., E. Pagnin, R. Okamoto, A.M. Corbacho, E. Olano, O.A. Davis, A. van der Vliet, L. Packer and C.E. Cross. Induction of stress proteins and MMP-9 by 0.8 ppm of ozone in murine skin. Biochemical and Biophysical Research Communications 305:1-6, 2003.

Dietrich, M., G. Block, E.P. Norkus, M. Hudes, M.G. Traber, C.E. Cross and L. Packer. Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase ³-tocopherol in vivo after adjustment for dietary antioxidant intakes. American Journal of Clinical Nutrition 77:160-166, 2003.

Cross, C.E.. The antioxidant milieu at asthmatic respiratory tract surfaces. Pediatric Research 53:365-368, 2003.

Morrissey, B.M., A. van der Vliet, J. Eiserich and C.E. Cross. Chapter 12, p. 261-283. Oxidative and nitrosative stress in cystic fibrosis: significance or triviality. In: J. Fuchs, M. Podda and L. Packer (Eds.) Redox-Genome Interaction in Health and Disease. Marcel Dekker, Inc., New York, 2003.

Corbacho, A.M., Y. Macotela, G. Nava, J.P. Eiserich, C.E. Cross, G.M. de la Escalera and C. Clapp. Cytokine induction of prolactin receptors mediates prolactin inhibition of nitric oxide synthesis in pulmonary fibroblasts. FEBS 544:171-175, 2003.

Cross, C.E., G. Valacchi, B. Schock, M. Wilson, S. Weber, J. Eiserich and A. van der Vliet. Environmental oxidant pollutant effects on biologic systems: a focus on micronutrient antioxidant-oxidant interactions. American Journal of Respiratory and Critical Care Medicine 166:S44-S50, 2002.

Dietrich, M, G Block, M Hudes, JD Morrow, EP Norkus, MG Traber, CE Cross and L Packer. Antioxidant supplementation decreases lipid peroxidation biomarker F2-isoprostanes in plasma of smokers. Cancer Epidemiology, Biomarkers Prevention 2002:11:7-13, 2002.

Cross, CE, G Valacchi, BC Schock, M Wilson, S Weber, JP Eiserich, and A. van der Vliet. Environmental oxidant pollunts effects on biologic systems. A focus on micronutrient antioxidant-oxidant interactions. amer J Resp Crit Care Med 166, 2002.

Valacchi, G.A., van der Vliet, B.C. Schock, T. Okamoto, U. Obermuller-Jevic, C.E. Cross, and L Packer. Ozone exposure activates oxidative stress responses in murine skin. Toxicology 179:163-170, 2002.

Obermueller-Jevic, UC, I Espiritu, AM Corbacho, CE Cross, and H Witschi. Lung tumor development in mice exposed to tobacco smoke and fed B-Carotene diets. Toxicological Sci 69, 23-29, 2002.

Reddy, S., E.I. Finkelstein, P.S. Wong, A. Phung, C.R. Cross, and A, van der Vliet. Identification of glutathione modifications by cigarette smoke. Free Radical Biology and Medicine 33(11):1490-1498, 2002.

Schelege, Es, MW Eldridge, CE Cross, WF Walby, and WC Adams. Differential effects of airway anesthesia on ozone-induced pulmonary responses in human subjects. Amer J Resp adn Crit Care Med 163:1121-1127, 2001.

Traber, MG, Bm Winklhofer-Roob, JM, Roob, G Koschsorur, R Aigner, CE Cross, R Ramakrishnan, and R Brigelius-Flohe. Vitamin E kinetics in somkers and nonsmokers. Free Rad Biol & Med 31:1368-1374, 2001.

Cross, CE, S Louie, S Kwack, P Wong, S Reddy and A van der Vliet. Atmospheric oxidants and respiratory tract surfaces. p. 225-236. In J. Fuchs and L. Packer (Eds.) Environmental Stressors in Health and Disease, 2001.

Traber, M.D., A van der Vliet, A.Z. Reznick, and C.E. Cross. Tobacco-related diseases: is there a role for antioxidant micronutrient supplementation? Clinics in Chest Medicine 21:173-186, 2000.

van der Vliet, A. and C.E. Cross. Oxidants, nitrosants, and the lung. American Journal of Medicine 109:398-421, 2000.

van der Vliet, A., and C.E. Cross. Phagocyte oxidants and nitric oxide in cystic fibrosis: new therapeutic targets? Current Opinion in Pulmonary Medicine 6(6), 2000.

van der Vliet, A., M.N. Nguyen, M.K. Shigenaga, J.P. Eiserich, G.P. Marelich, and C.E. Cross. Myeloperoxidase and protein oxidation in cystic fibrosis. American Journal of Physiology 279:L537-L546, 2000.

van der Vliet, A., J.P. Eiserich, and C.E. Cross. Nitric oxide: a pro-inflammatory mediator in lung disease? Respiratory Research 1:67-72, 2000.

Cross, C.E., M. Traber, J. Eiserich, and A. van der Vliet. Micronutrient antioxidants and smoking. British Medical Bulletin 55:691-704, 1999.

van der Vliet, A, CA O'Neill, CE Cross, JM Koostra, WG Volz, B Halliwell and S Louie. Determination of antioxidant concentrations in human respiratory tract lining fluids. Amer J Physiol 276:L289-L296, 1998.

Eiserich, J.P., M. Hristova, C.E. Cross, A.D. Jones, B.A. Freeman, B. Halliwell and A. van der Vliet. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 391, 393-397, 1998.

Haas, A.F., J.W. Wong, C.K. Iwahashi, B. Halliwell, C.E. Cross and P.A. Davis. Redox regulation of wound healing? NF-B activation in cultured human keratinocytes upon wounding and the effect of low energy hene irradiation. Free Radical Biology & Medicine, 25:1-8, 1998.

van der Vliet, A., M. Hristova, C.E. Cross, J.P. Eiserich and T. Goldkorn. Peroxynitrite induces covalent dimerization of epidermal growth factor receptors in A431 epidermoid carcinoma cells. Journal of Biological Chemistry 273, 31860-31866, 1998.

van der Vliet, A., P.A. Chr.'t Hoen, P.S.-Y Wong, A. Bast and C.E. Cross. Formation of S-nitrothiols via a direct nucleophilic nitrosation of thiols by peroxynitrite with elimination of hydrogen peroxide. Journal of Biological Chemistry 273, 30255-30262, 1998.

van der Vliet, A., C.E. Cross and J.P. Eiserich. Reactive oxygen and nitrogen species and adult respiratory distress syndrome (ARDS): New mechanisms to be considered. In: Acute Respiratory Distress Syndrome. Cellular and Moecular Mechanisms and Clinical Management, S. Matalon and J.I. Sznajder (Eds.), Plenum Press, New York, N.Y., pp. 401-414, 1998.

van der Vliet, A., A. Jenner, J.P. Eiserich, C.E. Cross and B. Halliwell. Analysis of aromatic nitration, chlorination, and hydroxylation by gas chromatography mass spectrometry. Methods in Enzymology, 301:471-483, 1998.

van der Vliet A, Eiserich JP, Halliwell B, Cross CE. Formation of reactive nitrogen intermediates during peroxidase-medicated toxicity. The Journal of Biological and Chemistry 1997;272:7617-7625.

Handelman, GJ, L Packer, and CE Cross. Destruction of tocopherols, carotenoids, and retinol in humna plasma by cigarette smoke. Amer J Clin Nut 63:559-565, 1996.

To see if Carroll E. Cross is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).