Dr. Yoon's clinical interests are in Diabetes Mellitus.
Dr. Yoon is interested in molecular studies of metabolic regulation and human disease, with a particular focus on diabetes mellitus. Ongoing work utilizes a combination of experimental systems and approaches to investigate the role of specific intracellular signaling pathways such as the Wnt pathway in the regulation of muscle metabolism and their impact on physiological and pathological adaptations.
Another area of interest is the contribution of mitochondrial defects and inflammatory processes to the development of metabolic disease. Large-scale genetic screens in muscle cells have been performed to isolate regulators of mitochondrial function and some of the identified genes are being characterized.
Endocrinology, Diabetes, and Metabolism
M.D., Harvard Medical School, Boston MA 2002
Ph.D., Biological Chemistry, Harvard Graduate School, Boston MA 2002
A.B., Harvard University, Cambridge MA 1990
Internal Medicine, New York Presbyterian Hospital, New York NY 2003-2004
Genetics, Brigham and Women's Hospital, Boston MA 2007-2009
Endocrinology, Massachusetts General Hospital, Boston MA 2004-2007
American Board of Internal Medicine,
American Board of Internal Medicine, Endocrinology, Diabetes and Metabolism,
Honors and Awards
Damon Runyon Cancer Research Foundation Fellow, 2007
Leon Reznick Prize for Excellence in Research, Harvard Medical School, 2002
Select Recent Publications
Yoon JC, Ling AL, Isik M, Lee DD, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT-1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci USA. 2014;111: 3781-3786.
Davoli T, Xu W, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013;155:948-962.
Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010;24:1507-1518.
Puigserver, P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili, and Spiegelman BM. Insulin-Regulated Hepatic Gluconeogenesis through FOXO1-PGC-1α Interaction. Nature. 2003;423(6939):550-555.
Yoon JC, Puigserver P, Chen G, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, and Spiegelman BM. Control of Hepatic Gluconeogenesis through the Transcriptional Coactivator PGC-1. Nature. 2001;413:131-138.