One of the earliest steps in either the generation of leukemia, or the genesis of a solid tumor is a break in DNA that is mis-repaired. In each case, the null hypothesis is that such breaks occur at random. In the case of leukemia, it is apparent that such breaks may be targeted to specific genes by aberrant action of normal gene products such as Activation Induced Cytidine Deaminase (AID). For the generation of solid tumors, the deletion of large tracts of DNA containing tumor suppressor genes may also be regulated by local DNA secondary structure and/or epigenetic modification. Proof of cellular control over such early events in tumorigenesis would disprove the null hypothesis and open up new areas for suppressing such tumor promoting events.
Ph.D., Birmingham University, Birmingham, UK, 1978
M.Sc., Birmingham University, Birmingham, UK, 1975
B.Sc., Portsmouth Polytechnic, Portsmouth, UK, 1974
American Association for Cancer Research
American Society for Therapeutic Radiology and Oncology
Institute of Biology: Chartered Biologist
Radiation Research Society of North America
Royal Society for Chemistry: Chartered Chemist
Select Recent Publications
Friedman DA, Tait L, Vaughan AT. Influence of nuclear structure on the formation of radiation-induced lethal lesions. Int J Radiat Biol. 2016 May;92(5):229-40.
Hess CB, Thompson HM, Benedict SH, Seibert JA, Wong K, Vaughan AT, Chen AM. Exposure Risks Among Children Undergoing Radiation Therapy: Considerations in the Era of Image Guided Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):978-92.
Sapareto SA, Vaughan AT, Orton CG. Point/Counterpoint. Spontaneous tumors in pets are an excellent translational model for human cancers. Med Phys. 2015 Nov;42(11):6127-9.
Liu R, Fan M, Candas D, Qin L, Zhang X, Eldridge A, Zou JX, Zhang T, Juma S, Jin C, Li RF, Perks J, Sun LQ, Vaughan AT, Hai CX, Gius DR, Li JJ. CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Mol Cancer Ther. 2015 Sep;14(9):2090-102.
Wright RL, Slemmons KK, Vaughan AT. Estradiol induces gene proximity and MLL-MLLT3 fusion in an activation-induced cytidine deaminase-mediated pathway. Leuk Lymphoma. 2015 May;56(5):1460-5.
Cui Y, Qin L, Wu J, Qu X, Hou C, Sun W, Li S, Vaughan AT, Li JJ, Liu J. SIRT3 Enhances Glycolysis and Proliferation in SIRT3-Expressing Gastric Cancer Cells. PLoS One. 2015 Jun 29;10(6):e0129834.
Jin C, Qin L, Shi Y, Candas D, Fan M, Lu CL, Vaughan AT, Shen R, Wu LS, Liu R, Li RF, Murley JS, Woloschak G, Grdina DJ, Li JJ. CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection. Free Radic Biol Med. 2015 Apr;81:77-87.
Wright RL, Vaughan AT. A systematic description of MLL fusion gene formation. Crit Rev Oncol Hematol. 2014 Sep;91(3):283-91.
Hess CB, Rash DL, Daly ME, Farwell DG, Bishop J, Vaughan AT, Wilson MD, Chen AM. Competing causes of death and medical comorbidities among patients with human papillomavirus-positive vs human papillomavirus-negative oropharyngeal carcinoma and impact on adherence to radiotherapy. JAMA Otolaryngol Head Neck Surg. 2014 Apr;140(4):312-6.
Singh S, Shih SJ, Vaughan AT. Detection of DNA double-strand breaks and chromosome translocations using ligation-mediated PCR and inverse PCR. Methods Mol Biol. 2014;1105:399-415.