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UC Davis Comprehensive Cancer Center

Maria Mudryj, Ph.D. View profile as PDF

Clinical Interests

Maria Mudryj's research encompasses studies of cell cycle dependent signaling cascades in both cellular proliferation and growth arrest. She also is investigating cell cycle regulation of transcription and cell cycle and apoptosis. In addition, Mudryj is interested in HCV-mediated alteration of growth and transformation.

Title:

Associate Professor

Specialty:

Medical Microbiology and Immunology

Division:

Medical Microbiology and Immunology

Center/Program Affiliation:

Education:

Fellowships:

Duke University Medical Center, Durham, North Carolina, 1987-90

Professional Memberships:

American Association for Cancer Research
American Gerontological Society

Select Recent Publications:

Afshari CA, Rhoades N, Paulis R, Mudryj M. Altered regulation of E2F transcription factor complexes in most transformed mouse fibroblasts. Oncogene 1997;14:3029-3038

Afshari CA, Nichols MA, Xiong Y, Mudryj M. A role for a p21-E2F interaction during senescence arrest of normal human fibroblasts. Cell Growth and Differentiation 1996;7/8:979-988

Devotao SH, Mudryj M, et. al. A cyclin A-protein kinase complex possesses sequence specific DNA binding activity... Cell 1992;68:167-176

Wade M, Kowalik TF, Mudryj M, et. al. E2F mediates dihydrofolate reductase promoter activation and multiprotein complex... Mol Cell Biol 1992;12: 4364-4374

Nevins JR, Challappan SP, Mudryj M, et. al. The E2F transcription factor is a target for the RB protein and the cyclin protein Cold Spring Harbor Laboratory Press 1991;0-87969-061-5