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UC Davis Comprehensive Cancer Center

Janine M. LaSalle, Ph.D. View profile as PDF

Clinical Interests

Janine M. LaSalle's research interests include nuclear organization, chromosome dynamics, and DNA replication in mammalian cells. She is also interested in molecular and cellular mechanisms of parental imprinting. LaSalle's research also includes epigenetic variation of DNA methylation in human T cell clones (fluorescence microscopy and flow cytometry).

Title:

Assistant Professor

Specialty:

Cancer, Medical Microbiology and Immunology

Division:

Medical Microbiology and Immunology

Center/Program Affiliation:

Education:

B.S., Randolph-Macon College, Ashland, Virginia, 1988

Fellowships:

Howard Hughes Medical Institute, Children?s Hospital, Boston, Massachusetts, 1993-96

Select Recent Publications:

LaSalle JM, Ritchie R, Glatt H, Lalande M. Clonal heterogeneity at allelic methylation sites diagnostic for Prader-Willi and Angelman syndromes. Proc. National Academy of Science 1998;95:1675-1680

Mizuta R, LaSalle JM, Cheng H-L, Shinohara A, Ogawa H, Copeland N, Jenkins NA, Lalande M, Alt FW. RAB22 and RAB163/mouse BRCA2: Proteins that specifically interact with RAD51 protein. Proc. National Academy of Science 1997; 94: 6927-6932

Strehl S, LaSalle JM, Lalande M. High resolution analysis of a DNA replication domain organization across an R/G-band boundary. Molecular Cellular Biology 1997;17: 6157-6166

LaSalle JM, Lalande M. Homologous association of oppositely imprinted chromosomal domains. Science, 1996;272:725-728

LaSalle JM, Lalande M. Domain organization of allele-specific replication within the GABRB3 gene cluster requires a biparental chromosome 15q11-13 contribution. Nature Genet. 1995;9:386-394