Dr. Lin is researching the stimulation of ATP-sensitive potassium channels.
Ph.D., University of Michigan Medical School, Ann Arbor, Michigan, 1995
B.S., National Taiwan University, Taipei, Taiwan, 1984
M.S., National Taiwan University, Taipei, Taiwan, 1986
Howard Hughes Medical Center, San Francisco, California, 2002
University of Michigan School of Medicine, Ann Arbor, Michigan, 1997
Select Recent Publications
Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN, Jan LY. Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc Natl Acad Sci USA, 101(13):4441-6.
Lin YF, Raab-Graham K, Jan YN, Jan LY. NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc Natl Acad Sci U S A, 101(20):7799-804.
Ma D, Zerangue N, Lin YF, Collins A, Yu M, Jan YN, Jan LY. Role of ER export signals in controlling surface potassium channel numbers. Science, 291(5502):316-9.
Yi BA, Lin YF, Jan YN, Jan LY. Yeast screen for constitutiely active mutant G protein-activated potassium channels. Neuron, 29(3):657-67.
Yi BA, Minor DL, Lin YF, Jan YN, Jan LY. Controlling potassium channel activities: Interplay between the membrane and intracellular factors. Proc Natl Acad Sci USA, 98(20):11016-23.
Lin YF, Jan YN, Jan LY. Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells. EMBO J, 19(5):942-55.
Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Jan LY, Berger JM. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell, 102(5):657-70.
Lin YF, Angelotti TP, Dudek EM, Browning MD, Macdonald RL. Protein kinase C phosphorylation of the ??1 and ??2L subunits of the GABAA receptor enhances whole-cell currents expressed in L929 fibroblasts. Mol Pharmacol, 50(1):185-95.
Lin YF, Browning MD, Dudek EM, Macdonald RL. Protein kinase C enhances recombinant bovine α1β1γ2L GABAA receptor whole-cell currents expressed in L929 fibroblasts. Neuron, 13(6):1421-31.
Chai CY, Wu WC, Wang S, Su CK, Lin YF, Yen CT, Kuo JS, Wayner MJ. Coexistence of autonomic and somatic mechanisms in the pressor areas of medulla in cats. Brain Res Bull, 29(1):15-26.
Yen CT, Hwang JC, Su CK, Lin YF, Yang JM, Chai CY. Differential actions of the medial region of caudal medulla on autonomic nerve activities. Clin Exp Pharmacol Physiol, 18(11):743-51.
Chai CY, Lin YF, Wang HY, Wu WC, Yen CT, Kuo JS, Wayner MJ. Inhibition of spinal reflexes by paramedian reticular nucleus. Brain Res Bull, 25(4):581-8.
Chai CY, Lin YF, Lin AMY, Pan CM, Lee EH, Kuo JS. Existence of a powerful inhibitory mechanism in the medial region of caudal medulla--with special reference to the paramedian reticular nucleus. Brain Res Bull, 20(4):515-28.
Lin AM, Pan CM, Lin YF, Kuo JS, Chan SH, Chai CY. A cardioinhibitory area in the midbrain central tegmental field of cats. Brain Res Bull, 18(6):699-707.