Yu-Fung Lin, Ph.D.
Associate Professor
Locations and Contact
Patient Support Services Building
Patient Support Services Building
4150 V St.
Sacramento, CA 95817
Phone: 916-734-5031
Additional Numbers
Physician Referrals
Clinical Interests
Dr. Lin is researching the stimulation of ATP-sensitive potassium channels.
Research/Academic Interests
Dr. Lin's research interest focuses on mechanistic understanding of how the function of ion channels, membrane proteins involved in cellular function such as hormone release, muscle tone, neural transmission, and cell survival or death, is modulated by novel signals. She is a cell physiologist.
Division
Anesthesiology/Physiology
Undergraduate School
B.S., National Taiwan University, Taipei, Taiwan 1984
Undergraduate School
M.S., National Taiwan University, Taipei, Taiwan 1986
Other School
Postgraduate Research, Physiology, UC San Francisco, San Francisco CA 2003
Other School
Postdoc, Neurology, University of Michigan School of Medicine, Ann Arbor MI 1997
Other School
Ph.D., Physiology, University of Michigan School of Medicine, Ann Arbor MI 1995
Fellowship
Postdoctoral Fellow, Physiology, Howard Hughes Medical Center, San Francisco CA 1997-2002
Fellowship
Neurology, University of Michigan School of Medicine, Ann Arbor MI 1995-1997
Senate Research Travel Award, UC Davis, 2010, 2012, 2013
Scientist Development Award, American Heart Association (National Center) 2007, 2008, 2009, 2010, 2011
Genome Center Proteomics Core Facility Pilot Project, UC Davis, 2009, 2010
Travel Award, Beijing Joint Conference of Physiological Sciences, American Physiology Society, 2008
Research Insurance Grant to Promote Extramural Funding, UC Davis, 2007, 2008
Harrison Endowed Chair in Diabetes Research Award, UC Davis, 2006
UC Davis Health System Research Award, UC Health System, 2005, 2006, 2007
Senate Research Travel Award, UC Davis, 2004, 2005, 2006, 2007, 2008
Lin YF. Potassium channels as molecular targets of endocannabinoids. Channels (Austin). 2021 Dec;15(1):408-423. doi:10.1080/19336950.2021.1910461. PMID:34282702.
Zhang DM, Lin YF. Functional Modulation of Sarcolemmal KATP Channels by Atrial Natriuretic Peptide-Elicited Intracellular Signaling in Adult Rabbit Ventricular Cardiomyocytes. Am J Physiol. Cell Physiol. 2020;319:C194-C207. doi:10.1152/ajpcell.00409.2019. Epub 2020 May 20.
Zhang DM, Chai Y, Erickson JR, Brown JH, Bers DM, Lin YF. Intracellular signaling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. J Physiol (London). 2014 Mar 1;1(592): 971-90.
Chai Y, Zhang DM, Lin YF. Activation of cGMP-dependent protein kinase stimulates cardiac-type ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade. PLoS One. 2011 Mar 29;6(3): e18.
Chai Y, Lin YF. Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: Involvement of ROS and 5- hydroxydecanoate-sensitive factors in signal transduction. Am J Physiol Cell Physiol. 2010;298:C875-C892.
Lin YF, Chai Y. Functional modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylation. Neuroscience. 2008;152: 371-380.
Chai Y, Lin YF. Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase. Pflügers Archiv - European J Physiol. 2008;456:897-915.
Misaki N, Mao X, Lin YF, Suga S, Li GH, Liu Q, Chang Y, Wang H, Wakui M, Wu J. Iptakalim, a vascular ATP-Sensitive potassium (KATP) channel opener, closes rat pancreatic β-Cell (KATP) channels and increases insulin release. J Pharmacol Exp Ther. 2007;322:871-8.
Mao X, Chai Y, Lin YF. Dual regulation of ATP-sensitive potassium channel by caffeine. Am J Physiol Cell Physiol. 2007;292:C2239-58.
Lin YF, Raab-Graham K, Jan YN, Jan LY. NO stimulation of ATP sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc Natl Acad Sci USA. 2004;101(20):7799-804.