Dr. Lin is researching the stimulation of ATP-sensitive potassium channels.
Ph.D., Physiology, University of Michigan Medical School, Ann Arbor MI 1995
B.S., National Taiwan University, Taipei, Taiwan, 1984
M.S., Zoology, National Taiwan University, Taipei, Taiwan, 1986
Howard Hughes Medical Center, San Francisco CA 1997-2002
University of Michigan School of Medicine, Ann Arbor MI 1995-1997
American Heart Association
American Physiological Society
Society for Neuroscience
Honors and Awards
Senate Research Travel Award, University of California, Davis, 2010, 2012, 2013
Scientist Development Award, American Heart Association (National Center) 2007-2011,
Genome Center Proteomics Core Facility Pilot Project, University of California, Davis, 2009-2010,
Travel Award, Beijing Joint Conference of Physiological Sciences, American Physiology Society, 2008
Research Insurance Grant to Promote Extramural Funding, University of California, Davis, 2007-2008,
Harrison Endowed Chair in Diabetes Research Award, University of California, Davis, 2006
UC Davis Health System Research Award, University of California Health System, 2005-2007,
Senate Research Travel Award, University of California, Davis, 2004-2008,
Select Recent Publications
Zhang DM, Chai Y, Erickson JR, Brown JH, Bers DM, Lin YF. Intracellular signaling mechanism responsible for modulation of sarcolemmal ATP-sensitive potassium channels by nitric oxide in ventricular cardiomyocytes. J Physiol (London). 2014 Mar 1;1(592): 971-90.
Chai Y, Zhang DM, Lin YF. Activation of cGMP-dependent protein kinase stimulates cardiac-type ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade. PLoS One. 2011 Mar 29;6(3): e18.
Chai Y, Lin YF. Stimulation of neuronal KATP channels by cGMP-dependent protein kinase: Involvement of ROS and 5- hydroxydecanoate-sensitive factors in signal transduction. Am J Physiol Cell Physiol. 2010;298: C875-C892.
Lin YF, Chai Y. Functional modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylation. Neuroscience. 2008;152: 371-380.
Chai Y, Lin YF. Dual regulation of the ATP-sensitive potassium channel by activation of cGMP-dependent protein kinase. Pflügers Archiv - European J Physiol. 2008;456: 897-915.
Misaki N, Mao X, Lin YF, Suga S, Li GH, Liu Q, Chang Y, Wang H, Wakui M, Wu J. Iptakalim, a vascular ATP-Sensitive potassium (KATP) channel opener, closes rat pancreatic β-Cell (KATP) channels and increases insulin release. J Pharmacol Exp Ther. 2007;322: 871-8.
Mao X, Chai Y, Lin YF. Dual regulation of ATP-sensitive potassium channel by caffeine. Am J Physiol Cell Physiol. 2007;292: C2239-58.
Lin YF, Raab-Graham K, Jan YN, Jan LY. NO stimulation of ATP sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc Natl Acad Sci USA. 2004;101(20): 7799-804.
Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN, Jan LY. Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc Natl Acad Sci USA, 101(13):4441-6.he medial region of caudal medulla--with special reference to the paramedian reticular nucleus. Brain Res Bull. 2004;20(4):515-28.
Yi BA, Minor DL, Lin YF, Jan YN, Jan LY. Controlling potassium channel activities: Interplay between the membrane and intracellular factors. Proc Natl Acad Sci USA. 2001;98(20): 11016-23.