Pediatric Heart Center | UC Davis Children's Hospital
  • UC Davis Pediatric Heart Center

The UC Davis Pediatric Heart Center is inland Northern California's only full-service pediatric heart center, offering the latest tests and treatments for a range of congenital heart conditions. Our integrated multidisciplinary team of surgeons, specialists, physicians, nurses and researchers provide some of Northern California's most sophisticated specialty and surgical expertise in:

  • Pediatric cardiology
  • Pediatric cardiothoracic surgery
  • Cardiac catheterization and electrophysiology
  • Neonatal and pediatric intensive care
  • Pediatric critical care nursing
  • Fetal diagnosis of heart defects

Our pediatric heart specialists treat patients both in Sacramento and throughout Northern California at our outreach clinics, which allow children in outlying areas to receive a consultation and evaluation without having to travel to Sacramento.

To schedule an appointment at any of our clinic locations, please call 916-734-3456.

The Pediatric Heart Center sees patients in the Sacramento area at the Glassrock Building (see map) on the campus of the UC Davis Medical Center and at the UC Davis Medical Group clinics in Roseville and Auburn.

We also schedule and hold monthly outreach clinics in Redding, Chico, Stockton, and Marysville. To schedule an appointment at any of our clinics, please call 916-734-3456.

View all clinic locations with maps and directions »

Surgical intervention for infants diagnosed with congenital heart disease addresses a variety of defects, including:

Some conditions may be treated using catheters - thin, flexible, narrow tubes threaded through blood vessels to the heart - rather than traditional, invasive cardiothoracic surgery. Cardiac catheterization can be used to make repairs, like closing holes in the heart muscle or removing obstructions from the blood vessels, or to place stents in narrowed or blocked blood vessels to keep them open.

Pediatric cardiac electrophysiology uses radiofrequency catheter ablation to treat cardiac arrhythmias, disrupting areas of the heart that are the source of the electrical irregularities.

Patient story, cardiothoracic surgery

Gary Raff, pediatric heart surgeon talks about what we do at UC Davis in the cardiac operating room. Patient story of Elijah Rangel who underwent surgery for congenital heart disease.

Pediatric heart patients recover in UC Davis' state-of-the-art Pediatric Intensive Care Unit/Pediatric Cardiac Intensive Care Unit (PICU/PCICU). The unit has a 2-to-1 patient-to-nurse ratio, and critical care medicine physicians are on site 24 hours a day, seven days a week.

Larger, single-patient rooms enhance family-centered care - a sleeping sofa and a chair in each room enable family members to remain at their child's bedside around the clock. Each room has its own bathroom.

Children who are well enough have access to an activity room with music, art and play therapy provided by the hospital's Child Life and Creative Arts Therapy Department. The program helps relieve the stress and anxiety of hospitalization.

The Pediatric Heart Center is part of the National Pediatric Cardiology Quality Improvement Collaborative, a group of 58 medical institutions that collaborates on quality improvement tools and methods to improve the health outcomes of care for children with cardiovascular disease and enhance communication between clinicians and parents. More information about the NPCQI's programs and outcomes is available from their website.



Pediatric Heart Center | UC Davis Children's Hospital
  • UC Davis Pediatric Heart Center

The UC Davis Pediatric Heart Center is inland Northern California's only full-service pediatric heart center, offering the latest tests and treatments for a range of congenital heart conditions. Our integrated multidisciplinary team of surgeons, specialists, physicians, nurses and researchers provide some of Northern California's most sophisticated specialty and surgical expertise in:

  • Pediatric cardiology
  • Pediatric cardiothoracic surgery
  • Cardiac catheterization and electrophysiology
  • Neonatal and pediatric intensive care
  • Pediatric critical care nursing
  • Fetal diagnosis of heart defects

Our pediatric heart specialists treat patients both in Sacramento and throughout Northern California at our outreach clinics, which allow children in outlying areas to receive a consultation and evaluation without having to travel to Sacramento.

To schedule an appointment at any of our clinic locations, please call 916-734-3456.

The Pediatric Heart Center sees patients in the Sacramento area at the Glassrock Building (see map) on the campus of the UC Davis Medical Center and at the UC Davis Medical Group clinics in Roseville and Auburn.

We also schedule and hold monthly outreach clinics in Redding, Chico, Stockton, and Marysville. To schedule an appointment at any of our clinics, please call 916-734-3456.

View all clinic locations with maps and directions »

Surgical intervention for infants diagnosed with congenital heart disease addresses a variety of defects, including:

Some conditions may be treated using catheters - thin, flexible, narrow tubes threaded through blood vessels to the heart - rather than traditional, invasive cardiothoracic surgery. Cardiac catheterization can be used to make repairs, like closing holes in the heart muscle or removing obstructions from the blood vessels, or to place stents in narrowed or blocked blood vessels to keep them open.

Pediatric cardiac electrophysiology uses radiofrequency catheter ablation to treat cardiac arrhythmias, disrupting areas of the heart that are the source of the electrical irregularities.

Patient story, cardiothoracic surgery

Gary Raff, pediatric heart surgeon talks about what we do at UC Davis in the cardiac operating room. Patient story of Elijah Rangel who underwent surgery for congenital heart disease.

Pediatric heart patients recover in UC Davis' state-of-the-art Pediatric Intensive Care Unit/Pediatric Cardiac Intensive Care Unit (PICU/PCICU). The unit has a 2-to-1 patient-to-nurse ratio, and critical care medicine physicians are on site 24 hours a day, seven days a week.

Larger, single-patient rooms enhance family-centered care - a sleeping sofa and a chair in each room enable family members to remain at their child's bedside around the clock. Each room has its own bathroom.

Children who are well enough have access to an activity room with music, art and play therapy provided by the hospital's Child Life and Creative Arts Therapy Department. The program helps relieve the stress and anxiety of hospitalization.

The Pediatric Heart Center is part of the National Pediatric Cardiology Quality Improvement Collaborative, a group of 58 medical institutions that collaborates on quality improvement tools and methods to improve the health outcomes of care for children with cardiovascular disease and enhance communication between clinicians and parents. More information about the NPCQI's programs and outcomes is available from their website.



New insights into how genes turn on and ...
Pediatric Heart Center | UC Davis Children's Hospital
  • UC Davis Pediatric Heart Center

The UC Davis Pediatric Heart Center is inland Northern California's only full-service pediatric heart center, offering the latest tests and treatments for a range of congenital heart conditions. Our integrated multidisciplinary team of surgeons, specialists, physicians, nurses and researchers provide some of Northern California's most sophisticated specialty and surgical expertise in:

  • Pediatric cardiology
  • Pediatric cardiothoracic surgery
  • Cardiac catheterization and electrophysiology
  • Neonatal and pediatric intensive care
  • Pediatric critical care nursing
  • Fetal diagnosis of heart defects

Our pediatric heart specialists treat patients both in Sacramento and throughout Northern California at our outreach clinics, which allow children in outlying areas to receive a consultation and evaluation without having to travel to Sacramento.

To schedule an appointment at any of our clinic locations, please call 916-734-3456.

The Pediatric Heart Center sees patients in the Sacramento area at the Glassrock Building (see map) on the campus of the UC Davis Medical Center and at the UC Davis Medical Group clinics in Roseville and Auburn.

We also schedule and hold monthly outreach clinics in Redding, Chico, Stockton, and Marysville. To schedule an appointment at any of our clinics, please call 916-734-3456.

View all clinic locations with maps and directions »

Surgical intervention for infants diagnosed with congenital heart disease addresses a variety of defects, including:

Some conditions may be treated using catheters - thin, flexible, narrow tubes threaded through blood vessels to the heart - rather than traditional, invasive cardiothoracic surgery. Cardiac catheterization can be used to make repairs, like closing holes in the heart muscle or removing obstructions from the blood vessels, or to place stents in narrowed or blocked blood vessels to keep them open.

Pediatric cardiac electrophysiology uses radiofrequency catheter ablation to treat cardiac arrhythmias, disrupting areas of the heart that are the source of the electrical irregularities.

Patient story, cardiothoracic surgery

Gary Raff, pediatric heart surgeon talks about what we do at UC Davis in the cardiac operating room. Patient story of Elijah Rangel who underwent surgery for congenital heart disease.

Pediatric heart patients recover in UC Davis' state-of-the-art Pediatric Intensive Care Unit/Pediatric Cardiac Intensive Care Unit (PICU/PCICU). The unit has a 2-to-1 patient-to-nurse ratio, and critical care medicine physicians are on site 24 hours a day, seven days a week.

Larger, single-patient rooms enhance family-centered care - a sleeping sofa and a chair in each room enable family members to remain at their child's bedside around the clock. Each room has its own bathroom.

Children who are well enough have access to an activity room with music, art and play therapy provided by the hospital's Child Life and Creative Arts Therapy Department. The program helps relieve the stress and anxiety of hospitalization.

The Pediatric Heart Center is part of the National Pediatric Cardiology Quality Improvement Collaborative, a group of 58 medical institutions that collaborates on quality improvement tools and methods to improve the health outcomes of care for children with cardiovascular disease and enhance communication between clinicians and parents. More information about the NPCQI's programs and outcomes is available from their website.



Pediatric Heart Center | UC Davis Children's Hospital
  • UC Davis Pediatric Heart Center

The UC Davis Pediatric Heart Center is inland Northern California's only full-service pediatric heart center, offering the latest tests and treatments for a range of congenital heart conditions. Our integrated multidisciplinary team of surgeons, specialists, physicians, nurses and researchers provide some of Northern California's most sophisticated specialty and surgical expertise in:

  • Pediatric cardiology
  • Pediatric cardiothoracic surgery
  • Cardiac catheterization and electrophysiology
  • Neonatal and pediatric intensive care
  • Pediatric critical care nursing
  • Fetal diagnosis of heart defects

Our pediatric heart specialists treat patients both in Sacramento and throughout Northern California at our outreach clinics, which allow children in outlying areas to receive a consultation and evaluation without having to travel to Sacramento.

To schedule an appointment at any of our clinic locations, please call 916-734-3456.

The Pediatric Heart Center sees patients in the Sacramento area at the Glassrock Building (see map) on the campus of the UC Davis Medical Center and at the UC Davis Medical Group clinics in Roseville and Auburn.

We also schedule and hold monthly outreach clinics in Redding, Chico, Stockton, and Marysville. To schedule an appointment at any of our clinics, please call 916-734-3456.

View all clinic locations with maps and directions »

Surgical intervention for infants diagnosed with congenital heart disease addresses a variety of defects, including:

Some conditions may be treated using catheters - thin, flexible, narrow tubes threaded through blood vessels to the heart - rather than traditional, invasive cardiothoracic surgery. Cardiac catheterization can be used to make repairs, like closing holes in the heart muscle or removing obstructions from the blood vessels, or to place stents in narrowed or blocked blood vessels to keep them open.

Pediatric cardiac electrophysiology uses radiofrequency catheter ablation to treat cardiac arrhythmias, disrupting areas of the heart that are the source of the electrical irregularities.

Patient story, cardiothoracic surgery

Gary Raff, pediatric heart surgeon talks about what we do at UC Davis in the cardiac operating room. Patient story of Elijah Rangel who underwent surgery for congenital heart disease.

Pediatric heart patients recover in UC Davis' state-of-the-art Pediatric Intensive Care Unit/Pediatric Cardiac Intensive Care Unit (PICU/PCICU). The unit has a 2-to-1 patient-to-nurse ratio, and critical care medicine physicians are on site 24 hours a day, seven days a week.

Larger, single-patient rooms enhance family-centered care - a sleeping sofa and a chair in each room enable family members to remain at their child's bedside around the clock. Each room has its own bathroom.

Children who are well enough have access to an activity room with music, art and play therapy provided by the hospital's Child Life and Creative Arts Therapy Department. The program helps relieve the stress and anxiety of hospitalization.

The Pediatric Heart Center is part of the National Pediatric Cardiology Quality Improvement Collaborative, a group of 58 medical institutions that collaborates on quality improvement tools and methods to improve the health outcomes of care for children with cardiovascular disease and enhance communication between clinicians and parents. More information about the NPCQI's programs and outcomes is available from their website.



NEWS | March 27, 2013

New insights into how genes turn on and off

Findings could enhance our understanding of human development, cancer therapies and autism

(SACRAMENTO, Calif.)

Researchers at UC Davis and the University of British Columbia have shed new light on methylation, a critical process that helps control how genes are expressed. Working with placentas, the team discovered that 37 percent of the placental genome has regions of lower methylation, called partially methylated domains (PMDs), in which gene expression is turned off. This differs from most human tissues, in which 70 percent of the genome is highly methylated.

Janine LaSalle Janine LaSalle

While PMDs have been identified in cell lines, this is the first time they have been found in regular human tissue. In addition to enhancing our understanding of epigenetics, this work could influence cancer research and help illuminate how environmental toxins affect fetal development. The paper was published online this week in the Proceedings of the National Academy of Sciences (PNAS).

 Since it was unraveled more than ten years ago, the human genome has been the focus of both popular interest and intense scientific focus. But the genome doesn’t act alone; there are many factors that influence whether genes are turned on or off. One of these is an epigenetic process called methylation, in which a group of carbon and hydrogen atoms (a methyl group) attaches to DNA, adjusting how genes are expressed.

“I like to think of epigenetics as a layer on top of your genetic code,” said senior author Janine LaSalle, professor of medical microbiology and immunology. “It’s not the DNA sequence but it layers on top of that — and methylation is the first layer. Those layers provide a lot of information to the cells on where and when to turn on the genes.”

How and when genes are activated (or inactivated) can have a profound impact on human development, cancer and the biological legacy of environmental toxins. Prior to this research, PMDs had only been found in cultured cell lines, which led some scientists to wonder if they existed outside the test tube. This study confirms they exist in placental tissue, a critically important window into fetal development.

“The placenta is the interface between mother and fetus,” said LaSalle, who is a researcher affiliated with the UC Davis MIND Institute. “It’s a time capsule from when a lot of important methylation events occurred.”

In addition, placental tissue was interesting to study because it has a number of invasive characteristics often associated with cancer. In fact, a number of cancers, such as breast and colon, have widespread PMDs. LaSalle notes that anti-cancer epigenetic therapies that adjust methylation could be refined based on this improved understanding of PMDs.

This work could also enhance our ability to detect genetic defects. Methylation, and other epigenetic data, provides information that cannot be found in the genome alone. For example, the vast majority of cells in the body contain identical genetic code. However, the added information provided by methylation allows scientists to determine where specific DNA came from.

“Methylation patterns are like fingerprints, showing which tissue that DNA is derived from,” LaSalle said. “You can’t get that information from just the DNA sequence. As a result, methylation studies could be a very rich source for biomarkers.”

In the study, PMDs encompassed 37 percent of the placental genome, including 3,815 genes, around 17 percent of all genes. When found in low-methylation regions, these genes were less likely to be transcribed into proteins. Researchers also found that PMDs also contain more highly methylated CpG islands (genomic areas with large numbers of cytosine-guanine pairs), which are often associated with gene transcriptional silencing of promoters.

Because the placental PMDs contained many genes associated with neuronal development, and specifically autism, LaSalle notes that future research could investigate how epigenetics impacts autism genes at birth.

“We are looking for biomarkers that predict neurodevelopmental outcomes,” LaSalle said. “Now we have a series of snap shots from a critical period where we think environmental factors are playing a role in the developing brain.”

The study’s other authors include : Diane I. Schroeder, John Blair, Paul Lott, Hung On Ken Yu, Danna Hong, Florence Crary, Paul Ashwood, Cheryl Walker, Ian Korf and Wendy P. Robinson.

At the UC Davis MIND Institute, world-renowned scientists engage in collaborative, interdisciplinary research to find the causes of and develop treatments and cures for autism, attention-deficit/hyperactivity disorder (ADHD), fragile X syndrome, 22q11.2 deletion syndrome, Down syndrome and other neurodevelopmental disorders. For more information, visit mindinstitute.ucdavis.edu

Pediatric Heart Center | UC Davis Children's Hospital
  • UC Davis Pediatric Heart Center

The UC Davis Pediatric Heart Center is inland Northern California's only full-service pediatric heart center, offering the latest tests and treatments for a range of congenital heart conditions. Our integrated multidisciplinary team of surgeons, specialists, physicians, nurses and researchers provide some of Northern California's most sophisticated specialty and surgical expertise in:

  • Pediatric cardiology
  • Pediatric cardiothoracic surgery
  • Cardiac catheterization and electrophysiology
  • Neonatal and pediatric intensive care
  • Pediatric critical care nursing
  • Fetal diagnosis of heart defects

Our pediatric heart specialists treat patients both in Sacramento and throughout Northern California at our outreach clinics, which allow children in outlying areas to receive a consultation and evaluation without having to travel to Sacramento.

To schedule an appointment at any of our clinic locations, please call 916-734-3456.

The Pediatric Heart Center sees patients in the Sacramento area at the Glassrock Building (see map) on the campus of the UC Davis Medical Center and at the UC Davis Medical Group clinics in Roseville and Auburn.

We also schedule and hold monthly outreach clinics in Redding, Chico, Stockton, and Marysville. To schedule an appointment at any of our clinics, please call 916-734-3456.

View all clinic locations with maps and directions »

Surgical intervention for infants diagnosed with congenital heart disease addresses a variety of defects, including:

Some conditions may be treated using catheters - thin, flexible, narrow tubes threaded through blood vessels to the heart - rather than traditional, invasive cardiothoracic surgery. Cardiac catheterization can be used to make repairs, like closing holes in the heart muscle or removing obstructions from the blood vessels, or to place stents in narrowed or blocked blood vessels to keep them open.

Pediatric cardiac electrophysiology uses radiofrequency catheter ablation to treat cardiac arrhythmias, disrupting areas of the heart that are the source of the electrical irregularities.

Patient story, cardiothoracic surgery

Gary Raff, pediatric heart surgeon talks about what we do at UC Davis in the cardiac operating room. Patient story of Elijah Rangel who underwent surgery for congenital heart disease.

Pediatric heart patients recover in UC Davis' state-of-the-art Pediatric Intensive Care Unit/Pediatric Cardiac Intensive Care Unit (PICU/PCICU). The unit has a 2-to-1 patient-to-nurse ratio, and critical care medicine physicians are on site 24 hours a day, seven days a week.

Larger, single-patient rooms enhance family-centered care - a sleeping sofa and a chair in each room enable family members to remain at their child's bedside around the clock. Each room has its own bathroom.

Children who are well enough have access to an activity room with music, art and play therapy provided by the hospital's Child Life and Creative Arts Therapy Department. The program helps relieve the stress and anxiety of hospitalization.

The Pediatric Heart Center is part of the National Pediatric Cardiology Quality Improvement Collaborative, a group of 58 medical institutions that collaborates on quality improvement tools and methods to improve the health outcomes of care for children with cardiovascular disease and enhance communication between clinicians and parents. More information about the NPCQI's programs and outcomes is available from their website.