Jeremy K. Nicholson, a leading researcher in the field of metabonomics — a platform for studying drug toxicity and gene function — is the keynote speaker at the 2014 Robert Stowell Lecture, held from 5 p.m. to 7 p.m. Monday, April 14, 2014 in the second floor auditorium of the Medical Education Building, 4610 X Street, Sacramento.
His lecture, “The Challenge of Implementing Systems Medicine Paradigms in a Changing World,” will demonstrate the possibilities for real-time diagnostics in surgery and molecular pathology approaches as tools for disruptive innovation in health care and the practice of medicine. The lecture and reception immediately following his presentation are open to the public. Guests are encouraged to register at http://stowell-lecture2014.eventbrite.com
Nicholson is the head of the Department of Surgery and Cancer, and director of MRC-NIHR National Phenome Centre at the Faculty of Medicine at Imperial College of London. A member and fellow of the Royal College of Pathologists, he established one of the world’s largest research groups in metabolic science. He also is the founder and director of Metabometrix, a company headquartered in central London on the South Kensington campus of Imperial College that has completed projects across a wide range of biomedical applications for both industrial and academic clients.
“We are thrilled to have such a distinguished and internationally acclaimed scientist and academician as Dr. Nicholson present our Robert Stowell lectureship on the topic of metabonomics, which has become the intersection for so many health science disciplines,” said Lydia Howell, professor and chair of the department of pathology and laboratory medicine. “We hope that his view from the forefront of research in this field will provide greater vision for us all and help spark collaboration among researchers throughout the UC Davis School of Medicine community.”
Satya Dandekar, professor and chair of the Department of Medical Microbiology and Immunology, is equally enthusiastic about the opportunity to engage Nicholson in discussions with faculty in Davis.
“Dr. Nicholson has provided outstanding leadership in developing innovative approaches of metabolism-driven monitoring to investigate patient responses to therapies,” Dandekar said. “His research investigations on deciphering the impact of gene environment interactions on the clinical outcomes through metabolomics have great potential in enhancing and empowering personalized healthcare. The Stowell Lecture series provides a wonderful opportunity for our junior clinical and basic biomedical researchers to engage in informative and thought-provoking discussions with Dr. Nicolson about the promise and potential of metabolomic science in human health and disease.”
The field of metabonomics characterizes the key biochemical changes caused by a range of interventions and conditions such as drug toxicity in animals and man, the diagnosis and course of clinical disease, the effects of therapeutic intervention and the impact of nutrition and life-style changes. This approach has the potential to impact strongly on drug discovery and development from lead molecule selection to marketing of clinically successful drugs. In the future, metabonomics could become a key driver for integrating knowledge at all of the levels of molecular biology to provide a true top-down systems biology understanding.
Nicholson has been awarded the Royal Society of Chemistry Gold and Silver Medals for Analytical Science. He obtained his doctorate from the University of London and subsequently became a postdoctoral fellow and professor of biological chemistry at Birkbeck College, London, and he has published extensively in the field.
His wide range of research interests include surgical metabolomics, personalized health care through metabolic phenotyping, real-time diagnostics and integrative patient modelling, molecular physio-chemical processes in metabolism and medicine, development of novel spectroscopic and chemometric tools for investigating human disease and toxicological mechanisms, metabolism-driven top-down systems biology and modelling of complex system failure.
The annual Stowell Lectureship is funded through a generous gift by the founding chair of the UC Davis Department of Pathology and Laboratory Medicine, Robert E. Stowell, whose distinguished career as a physician and scientist included service as the director of the Armed Forces Institute of Pathology and chair of the Department of Pathology at the University of Kansas.
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