Office of the Vice Chancellor and Dean | UC Davis Health

Welcome Dr. David Lubarsky to UC Davis Health!

David A. LubarskyUC Davis Chancellor Gary May has appointed David A. Lubarsky to the position of vice chancellor of human health sciences and chief executive officer of UC Davis Health, which includes the School of Medicine, the Betty Irene Moore School of Nursing, the 1,000-member physician practice group, and UC Davis Medical Center, a 627-bed acute-care hospital. Lubarsky will join UC Davis on July 2, 2018.

Lubarsky most recently served as the chief medical and systems integration officer with the University of Miami Health System, a position he has held since 2012. As a leader within the system, he has overseen the system’s four hospital and practice chief medical officers as well as patient safety and quality. In addition, he led the university’s self-insured malpractice program, which focuses on prevention, and patient and visitor services, including patient experience. During his tenure at the University of Miami, Lubarsky integrated programs to create system-wide consistent approaches to care and quality improvement, including a new central safety and quality office, a system-wide safety and quality governing board, a system-wide chief medical officer council, a system-wide infection control and antibiotic stewardship program, and a central PI and project management office.

"David brings to UC Davis broad experience and proven results in a major healthcare market," May said. "He has an impressive record of sound financial management and innovative practices for a high functioning health care system that has gained national attention. His success in raising funds to meet pressing needs, including for enhanced access to Medicaid and indigent patients, aligns well with our values at UC Davis Health."

Lubarsky has been recognized for his success in helping establish a centralized scheduling system, improving infrastructure, and improving performance across many areas of the University of Miami health system. He raised more than $100 million annually for the University of Miami from state and federal funding sources to aid enhanced access for Medicaid and indigent patients. Previously, as CEO of the 1,100-physician practice, he turned a $100 million loss into a $32 million surplus in one year by growing patient volumes and optimizing the revenue cycle while making sure already high patient experience scores were maintained. Of note, every one of his major initiatives has explicitly prioritized quality and empathetic patient care.

In his efforts to meet community needs, Lubarsky has worked with the state of Florida and Centers for Medicare & Medicaid Services to expand access to Medicaid, forging a close partnership with the other major academic centers in Florida in pursuit of this goal. He has also been working with Florida’s state and congressional representatives to expand existing graduate medical education programs that would best meet the state’s needs and to secure the necessary federal funding which has been frozen for more than 20 years.

For the last 16 years, Lubarsky has been chief of service of anesthesia and pain management for the largest safety net hospital in the U.S., Jackson Memorial Hospital. He served on their board overseeing safety and quality, and throughout his tenure has been a forceful advocate for a uniform high quality of care.

"It is a privilege to join this highly regarded, progressive and nationally recognized health system," Lubarsky said. "I look forward to working closely with the accomplished faculty and staff, and routinely interacting with Davis’ talented students and trainees. I have already heard many great ideas about how to catapult Davis to greater heights, and I hope to harness those ideas to catalyze innovation so that we better serve our patients, our local community and our academic mission."

UC Davis School of Medicine is one of the nation's leading medical schools, recognized for its research and primary-care programs. Ranked 34th in National Institutes of Health funding in 2013, it is designated as one of the nation’s inaugural Clinical Translational Science Centers.

A few highlights include:

  • A national reputation for life-changing biomedical discoveries
  • A passion for clinical care and a commitment to engaging people from underserved communities and advancing rural health
  • Fully accredited master’s degree programs in public health and in informatics
  • A combined M.D.-Ph.D. program that is training the next generation of physician-scientists to conduct high-impact research and translate discoveries into better clinical care

The Dean’s Departments and Offices include:

Additional departments:

To learn more, visit the medical school site.

UC Davis Medical Center, based in Sacramento, Calif., is a nationally renowned academic medical center where clinical practice, teaching and research converge to advance human health.

A few highlights:

  • A 627-bed multispecialty academic medical center
  • Serves 33 counties covering a 65,000-square-mile area north to the Oregon border and east to Nevada
  • Recognized as one of the “Most Wired” hospitals in the U.S.
  • Recognized by The Leapfrog Group as a “Top Hospital” for delivery of high-quality care
  • Ranked Sacramento's top hospital by U.S. News & World Report

Centers of excellence include:

  • UC Davis Comprehensive Cancer Center, one of only 41 National Cancer Institute-designated comprehensive centers nationwide
  • State-of-the-art emergency departments that include the region's only Level I adult and pediatric trauma centers
  • The internationally recognized UC Davis MIND Institute, devoted to finding treatments and cures for neurodevelopmental disorders
  • UC Davis Children's Hospital, a nationally ranked pediatric hospital with more than 120 physicians in 33 pediatric subspecialties
  • A pioneering telehealth program, which gives remote, underserved communities access to academic specialty and subspecialty care

To learn more, visit the medical center site.

The Betty Irene Moore School of Nursing at UC Davis cultivates academic excellence and addresses urgent, societal needs through leadership development, interprofessional education, transformative research, cultural inclusiveness and innovative technology. The school plays a critical role in preparing nurse leaders who will shape the future of health care and inform health policy.

The School of Nursing has five research focus areas: chronic disease management, health technology, pain management, Healthy People and Healthy Systems. Faculty come from a wide range of backgrounds including nursing, business administration, sociology, gerontology, medicine, information technology and psychology. School of Nursing students engage in classroom and clinical environments with students in the School of Medicine, health informatics and other health-related programs.

A few highlights include:

To learn more, visit the School of Nursing’s website.

The Practice Management Group (TPMG) represents all organized medical group practices of UC Davis Health System’s primary and specialty care faculty physicians. The group's purpose is to serve the health system’s missions through high-quality, cost-effective care delivery. By delegation from the Office of the Vice Chancellor and Dean, TPMG has shared responsibility for the clinical operations of the health system's professional practice activities.

The formation of TPMG is an important step in formalizing the leadership of the health system's medical group practices and in refining the role of its group practice in achieving the health system's research, teaching, patient care and community engagement goals. Its primary goal is to maintain a clinical practice that distinguishes UC Davis Health System as a leading faculty and academic health center.

Specific goals of TPMG include:

  • Increasing efficiency of practice and revenue
  • Decreasing practice expenses
  • Reducing silos and improving integration
  • Identifying areas to increase quality
  • Aligning incentives

David H. Wisner is the executive director of the Practice Management Group, overseeing faculty practice operations as well as the overall vision and strategic direction of TPMG and its day-to-day activities. Wisner collaborates with the leadership of the School of Medicine and medical center to set and achieve joint strategic goals across the health system.

More information



Office of the Vice Chancellor and Dean | UC Davis Health

Welcome Dr. David Lubarsky to UC Davis Health!

David A. LubarskyUC Davis Chancellor Gary May has appointed David A. Lubarsky to the position of vice chancellor of human health sciences and chief executive officer of UC Davis Health, which includes the School of Medicine, the Betty Irene Moore School of Nursing, the 1,000-member physician practice group, and UC Davis Medical Center, a 627-bed acute-care hospital. Lubarsky will join UC Davis on July 2, 2018.

Lubarsky most recently served as the chief medical and systems integration officer with the University of Miami Health System, a position he has held since 2012. As a leader within the system, he has overseen the system’s four hospital and practice chief medical officers as well as patient safety and quality. In addition, he led the university’s self-insured malpractice program, which focuses on prevention, and patient and visitor services, including patient experience. During his tenure at the University of Miami, Lubarsky integrated programs to create system-wide consistent approaches to care and quality improvement, including a new central safety and quality office, a system-wide safety and quality governing board, a system-wide chief medical officer council, a system-wide infection control and antibiotic stewardship program, and a central PI and project management office.

"David brings to UC Davis broad experience and proven results in a major healthcare market," May said. "He has an impressive record of sound financial management and innovative practices for a high functioning health care system that has gained national attention. His success in raising funds to meet pressing needs, including for enhanced access to Medicaid and indigent patients, aligns well with our values at UC Davis Health."

Lubarsky has been recognized for his success in helping establish a centralized scheduling system, improving infrastructure, and improving performance across many areas of the University of Miami health system. He raised more than $100 million annually for the University of Miami from state and federal funding sources to aid enhanced access for Medicaid and indigent patients. Previously, as CEO of the 1,100-physician practice, he turned a $100 million loss into a $32 million surplus in one year by growing patient volumes and optimizing the revenue cycle while making sure already high patient experience scores were maintained. Of note, every one of his major initiatives has explicitly prioritized quality and empathetic patient care.

In his efforts to meet community needs, Lubarsky has worked with the state of Florida and Centers for Medicare & Medicaid Services to expand access to Medicaid, forging a close partnership with the other major academic centers in Florida in pursuit of this goal. He has also been working with Florida’s state and congressional representatives to expand existing graduate medical education programs that would best meet the state’s needs and to secure the necessary federal funding which has been frozen for more than 20 years.

For the last 16 years, Lubarsky has been chief of service of anesthesia and pain management for the largest safety net hospital in the U.S., Jackson Memorial Hospital. He served on their board overseeing safety and quality, and throughout his tenure has been a forceful advocate for a uniform high quality of care.

"It is a privilege to join this highly regarded, progressive and nationally recognized health system," Lubarsky said. "I look forward to working closely with the accomplished faculty and staff, and routinely interacting with Davis’ talented students and trainees. I have already heard many great ideas about how to catapult Davis to greater heights, and I hope to harness those ideas to catalyze innovation so that we better serve our patients, our local community and our academic mission."

UC Davis School of Medicine is one of the nation's leading medical schools, recognized for its research and primary-care programs. Ranked 34th in National Institutes of Health funding in 2013, it is designated as one of the nation’s inaugural Clinical Translational Science Centers.

A few highlights include:

  • A national reputation for life-changing biomedical discoveries
  • A passion for clinical care and a commitment to engaging people from underserved communities and advancing rural health
  • Fully accredited master’s degree programs in public health and in informatics
  • A combined M.D.-Ph.D. program that is training the next generation of physician-scientists to conduct high-impact research and translate discoveries into better clinical care

The Dean’s Departments and Offices include:

Additional departments:

To learn more, visit the medical school site.

UC Davis Medical Center, based in Sacramento, Calif., is a nationally renowned academic medical center where clinical practice, teaching and research converge to advance human health.

A few highlights:

  • A 627-bed multispecialty academic medical center
  • Serves 33 counties covering a 65,000-square-mile area north to the Oregon border and east to Nevada
  • Recognized as one of the “Most Wired” hospitals in the U.S.
  • Recognized by The Leapfrog Group as a “Top Hospital” for delivery of high-quality care
  • Ranked Sacramento's top hospital by U.S. News & World Report

Centers of excellence include:

  • UC Davis Comprehensive Cancer Center, one of only 41 National Cancer Institute-designated comprehensive centers nationwide
  • State-of-the-art emergency departments that include the region's only Level I adult and pediatric trauma centers
  • The internationally recognized UC Davis MIND Institute, devoted to finding treatments and cures for neurodevelopmental disorders
  • UC Davis Children's Hospital, a nationally ranked pediatric hospital with more than 120 physicians in 33 pediatric subspecialties
  • A pioneering telehealth program, which gives remote, underserved communities access to academic specialty and subspecialty care

To learn more, visit the medical center site.

The Betty Irene Moore School of Nursing at UC Davis cultivates academic excellence and addresses urgent, societal needs through leadership development, interprofessional education, transformative research, cultural inclusiveness and innovative technology. The school plays a critical role in preparing nurse leaders who will shape the future of health care and inform health policy.

The School of Nursing has five research focus areas: chronic disease management, health technology, pain management, Healthy People and Healthy Systems. Faculty come from a wide range of backgrounds including nursing, business administration, sociology, gerontology, medicine, information technology and psychology. School of Nursing students engage in classroom and clinical environments with students in the School of Medicine, health informatics and other health-related programs.

A few highlights include:

To learn more, visit the School of Nursing’s website.

The Practice Management Group (TPMG) represents all organized medical group practices of UC Davis Health System’s primary and specialty care faculty physicians. The group's purpose is to serve the health system’s missions through high-quality, cost-effective care delivery. By delegation from the Office of the Vice Chancellor and Dean, TPMG has shared responsibility for the clinical operations of the health system's professional practice activities.

The formation of TPMG is an important step in formalizing the leadership of the health system's medical group practices and in refining the role of its group practice in achieving the health system's research, teaching, patient care and community engagement goals. Its primary goal is to maintain a clinical practice that distinguishes UC Davis Health System as a leading faculty and academic health center.

Specific goals of TPMG include:

  • Increasing efficiency of practice and revenue
  • Decreasing practice expenses
  • Reducing silos and improving integration
  • Identifying areas to increase quality
  • Aligning incentives

David H. Wisner is the executive director of the Practice Management Group, overseeing faculty practice operations as well as the overall vision and strategic direction of TPMG and its day-to-day activities. Wisner collaborates with the leadership of the School of Medicine and medical center to set and achieve joint strategic goals across the health system.

More information



New combination drug controls tumor growth and metastasis ...
Office of the Vice Chancellor and Dean | UC Davis Health

Welcome Dr. David Lubarsky to UC Davis Health!

David A. LubarskyUC Davis Chancellor Gary May has appointed David A. Lubarsky to the position of vice chancellor of human health sciences and chief executive officer of UC Davis Health, which includes the School of Medicine, the Betty Irene Moore School of Nursing, the 1,000-member physician practice group, and UC Davis Medical Center, a 627-bed acute-care hospital. Lubarsky will join UC Davis on July 2, 2018.

Lubarsky most recently served as the chief medical and systems integration officer with the University of Miami Health System, a position he has held since 2012. As a leader within the system, he has overseen the system’s four hospital and practice chief medical officers as well as patient safety and quality. In addition, he led the university’s self-insured malpractice program, which focuses on prevention, and patient and visitor services, including patient experience. During his tenure at the University of Miami, Lubarsky integrated programs to create system-wide consistent approaches to care and quality improvement, including a new central safety and quality office, a system-wide safety and quality governing board, a system-wide chief medical officer council, a system-wide infection control and antibiotic stewardship program, and a central PI and project management office.

"David brings to UC Davis broad experience and proven results in a major healthcare market," May said. "He has an impressive record of sound financial management and innovative practices for a high functioning health care system that has gained national attention. His success in raising funds to meet pressing needs, including for enhanced access to Medicaid and indigent patients, aligns well with our values at UC Davis Health."

Lubarsky has been recognized for his success in helping establish a centralized scheduling system, improving infrastructure, and improving performance across many areas of the University of Miami health system. He raised more than $100 million annually for the University of Miami from state and federal funding sources to aid enhanced access for Medicaid and indigent patients. Previously, as CEO of the 1,100-physician practice, he turned a $100 million loss into a $32 million surplus in one year by growing patient volumes and optimizing the revenue cycle while making sure already high patient experience scores were maintained. Of note, every one of his major initiatives has explicitly prioritized quality and empathetic patient care.

In his efforts to meet community needs, Lubarsky has worked with the state of Florida and Centers for Medicare & Medicaid Services to expand access to Medicaid, forging a close partnership with the other major academic centers in Florida in pursuit of this goal. He has also been working with Florida’s state and congressional representatives to expand existing graduate medical education programs that would best meet the state’s needs and to secure the necessary federal funding which has been frozen for more than 20 years.

For the last 16 years, Lubarsky has been chief of service of anesthesia and pain management for the largest safety net hospital in the U.S., Jackson Memorial Hospital. He served on their board overseeing safety and quality, and throughout his tenure has been a forceful advocate for a uniform high quality of care.

"It is a privilege to join this highly regarded, progressive and nationally recognized health system," Lubarsky said. "I look forward to working closely with the accomplished faculty and staff, and routinely interacting with Davis’ talented students and trainees. I have already heard many great ideas about how to catapult Davis to greater heights, and I hope to harness those ideas to catalyze innovation so that we better serve our patients, our local community and our academic mission."

UC Davis School of Medicine is one of the nation's leading medical schools, recognized for its research and primary-care programs. Ranked 34th in National Institutes of Health funding in 2013, it is designated as one of the nation’s inaugural Clinical Translational Science Centers.

A few highlights include:

  • A national reputation for life-changing biomedical discoveries
  • A passion for clinical care and a commitment to engaging people from underserved communities and advancing rural health
  • Fully accredited master’s degree programs in public health and in informatics
  • A combined M.D.-Ph.D. program that is training the next generation of physician-scientists to conduct high-impact research and translate discoveries into better clinical care

The Dean’s Departments and Offices include:

Additional departments:

To learn more, visit the medical school site.

UC Davis Medical Center, based in Sacramento, Calif., is a nationally renowned academic medical center where clinical practice, teaching and research converge to advance human health.

A few highlights:

  • A 627-bed multispecialty academic medical center
  • Serves 33 counties covering a 65,000-square-mile area north to the Oregon border and east to Nevada
  • Recognized as one of the “Most Wired” hospitals in the U.S.
  • Recognized by The Leapfrog Group as a “Top Hospital” for delivery of high-quality care
  • Ranked Sacramento's top hospital by U.S. News & World Report

Centers of excellence include:

  • UC Davis Comprehensive Cancer Center, one of only 41 National Cancer Institute-designated comprehensive centers nationwide
  • State-of-the-art emergency departments that include the region's only Level I adult and pediatric trauma centers
  • The internationally recognized UC Davis MIND Institute, devoted to finding treatments and cures for neurodevelopmental disorders
  • UC Davis Children's Hospital, a nationally ranked pediatric hospital with more than 120 physicians in 33 pediatric subspecialties
  • A pioneering telehealth program, which gives remote, underserved communities access to academic specialty and subspecialty care

To learn more, visit the medical center site.

The Betty Irene Moore School of Nursing at UC Davis cultivates academic excellence and addresses urgent, societal needs through leadership development, interprofessional education, transformative research, cultural inclusiveness and innovative technology. The school plays a critical role in preparing nurse leaders who will shape the future of health care and inform health policy.

The School of Nursing has five research focus areas: chronic disease management, health technology, pain management, Healthy People and Healthy Systems. Faculty come from a wide range of backgrounds including nursing, business administration, sociology, gerontology, medicine, information technology and psychology. School of Nursing students engage in classroom and clinical environments with students in the School of Medicine, health informatics and other health-related programs.

A few highlights include:

To learn more, visit the School of Nursing’s website.

The Practice Management Group (TPMG) represents all organized medical group practices of UC Davis Health System’s primary and specialty care faculty physicians. The group's purpose is to serve the health system’s missions through high-quality, cost-effective care delivery. By delegation from the Office of the Vice Chancellor and Dean, TPMG has shared responsibility for the clinical operations of the health system's professional practice activities.

The formation of TPMG is an important step in formalizing the leadership of the health system's medical group practices and in refining the role of its group practice in achieving the health system's research, teaching, patient care and community engagement goals. Its primary goal is to maintain a clinical practice that distinguishes UC Davis Health System as a leading faculty and academic health center.

Specific goals of TPMG include:

  • Increasing efficiency of practice and revenue
  • Decreasing practice expenses
  • Reducing silos and improving integration
  • Identifying areas to increase quality
  • Aligning incentives

David H. Wisner is the executive director of the Practice Management Group, overseeing faculty practice operations as well as the overall vision and strategic direction of TPMG and its day-to-day activities. Wisner collaborates with the leadership of the School of Medicine and medical center to set and achieve joint strategic goals across the health system.

More information



Office of the Vice Chancellor and Dean | UC Davis Health

Welcome Dr. David Lubarsky to UC Davis Health!

David A. LubarskyUC Davis Chancellor Gary May has appointed David A. Lubarsky to the position of vice chancellor of human health sciences and chief executive officer of UC Davis Health, which includes the School of Medicine, the Betty Irene Moore School of Nursing, the 1,000-member physician practice group, and UC Davis Medical Center, a 627-bed acute-care hospital. Lubarsky will join UC Davis on July 2, 2018.

Lubarsky most recently served as the chief medical and systems integration officer with the University of Miami Health System, a position he has held since 2012. As a leader within the system, he has overseen the system’s four hospital and practice chief medical officers as well as patient safety and quality. In addition, he led the university’s self-insured malpractice program, which focuses on prevention, and patient and visitor services, including patient experience. During his tenure at the University of Miami, Lubarsky integrated programs to create system-wide consistent approaches to care and quality improvement, including a new central safety and quality office, a system-wide safety and quality governing board, a system-wide chief medical officer council, a system-wide infection control and antibiotic stewardship program, and a central PI and project management office.

"David brings to UC Davis broad experience and proven results in a major healthcare market," May said. "He has an impressive record of sound financial management and innovative practices for a high functioning health care system that has gained national attention. His success in raising funds to meet pressing needs, including for enhanced access to Medicaid and indigent patients, aligns well with our values at UC Davis Health."

Lubarsky has been recognized for his success in helping establish a centralized scheduling system, improving infrastructure, and improving performance across many areas of the University of Miami health system. He raised more than $100 million annually for the University of Miami from state and federal funding sources to aid enhanced access for Medicaid and indigent patients. Previously, as CEO of the 1,100-physician practice, he turned a $100 million loss into a $32 million surplus in one year by growing patient volumes and optimizing the revenue cycle while making sure already high patient experience scores were maintained. Of note, every one of his major initiatives has explicitly prioritized quality and empathetic patient care.

In his efforts to meet community needs, Lubarsky has worked with the state of Florida and Centers for Medicare & Medicaid Services to expand access to Medicaid, forging a close partnership with the other major academic centers in Florida in pursuit of this goal. He has also been working with Florida’s state and congressional representatives to expand existing graduate medical education programs that would best meet the state’s needs and to secure the necessary federal funding which has been frozen for more than 20 years.

For the last 16 years, Lubarsky has been chief of service of anesthesia and pain management for the largest safety net hospital in the U.S., Jackson Memorial Hospital. He served on their board overseeing safety and quality, and throughout his tenure has been a forceful advocate for a uniform high quality of care.

"It is a privilege to join this highly regarded, progressive and nationally recognized health system," Lubarsky said. "I look forward to working closely with the accomplished faculty and staff, and routinely interacting with Davis’ talented students and trainees. I have already heard many great ideas about how to catapult Davis to greater heights, and I hope to harness those ideas to catalyze innovation so that we better serve our patients, our local community and our academic mission."

UC Davis School of Medicine is one of the nation's leading medical schools, recognized for its research and primary-care programs. Ranked 34th in National Institutes of Health funding in 2013, it is designated as one of the nation’s inaugural Clinical Translational Science Centers.

A few highlights include:

  • A national reputation for life-changing biomedical discoveries
  • A passion for clinical care and a commitment to engaging people from underserved communities and advancing rural health
  • Fully accredited master’s degree programs in public health and in informatics
  • A combined M.D.-Ph.D. program that is training the next generation of physician-scientists to conduct high-impact research and translate discoveries into better clinical care

The Dean’s Departments and Offices include:

Additional departments:

To learn more, visit the medical school site.

UC Davis Medical Center, based in Sacramento, Calif., is a nationally renowned academic medical center where clinical practice, teaching and research converge to advance human health.

A few highlights:

  • A 627-bed multispecialty academic medical center
  • Serves 33 counties covering a 65,000-square-mile area north to the Oregon border and east to Nevada
  • Recognized as one of the “Most Wired” hospitals in the U.S.
  • Recognized by The Leapfrog Group as a “Top Hospital” for delivery of high-quality care
  • Ranked Sacramento's top hospital by U.S. News & World Report

Centers of excellence include:

  • UC Davis Comprehensive Cancer Center, one of only 41 National Cancer Institute-designated comprehensive centers nationwide
  • State-of-the-art emergency departments that include the region's only Level I adult and pediatric trauma centers
  • The internationally recognized UC Davis MIND Institute, devoted to finding treatments and cures for neurodevelopmental disorders
  • UC Davis Children's Hospital, a nationally ranked pediatric hospital with more than 120 physicians in 33 pediatric subspecialties
  • A pioneering telehealth program, which gives remote, underserved communities access to academic specialty and subspecialty care

To learn more, visit the medical center site.

The Betty Irene Moore School of Nursing at UC Davis cultivates academic excellence and addresses urgent, societal needs through leadership development, interprofessional education, transformative research, cultural inclusiveness and innovative technology. The school plays a critical role in preparing nurse leaders who will shape the future of health care and inform health policy.

The School of Nursing has five research focus areas: chronic disease management, health technology, pain management, Healthy People and Healthy Systems. Faculty come from a wide range of backgrounds including nursing, business administration, sociology, gerontology, medicine, information technology and psychology. School of Nursing students engage in classroom and clinical environments with students in the School of Medicine, health informatics and other health-related programs.

A few highlights include:

To learn more, visit the School of Nursing’s website.

The Practice Management Group (TPMG) represents all organized medical group practices of UC Davis Health System’s primary and specialty care faculty physicians. The group's purpose is to serve the health system’s missions through high-quality, cost-effective care delivery. By delegation from the Office of the Vice Chancellor and Dean, TPMG has shared responsibility for the clinical operations of the health system's professional practice activities.

The formation of TPMG is an important step in formalizing the leadership of the health system's medical group practices and in refining the role of its group practice in achieving the health system's research, teaching, patient care and community engagement goals. Its primary goal is to maintain a clinical practice that distinguishes UC Davis Health System as a leading faculty and academic health center.

Specific goals of TPMG include:

  • Increasing efficiency of practice and revenue
  • Decreasing practice expenses
  • Reducing silos and improving integration
  • Identifying areas to increase quality
  • Aligning incentives

David H. Wisner is the executive director of the Practice Management Group, overseeing faculty practice operations as well as the overall vision and strategic direction of TPMG and its day-to-day activities. Wisner collaborates with the leadership of the School of Medicine and medical center to set and achieve joint strategic goals across the health system.

More information



NEWS | July 14, 2014

New combination drug controls tumor growth and metastasis in mice

(SACRAMENTO)

Researchers at UC Davis, University of Massachusetts and Harvard Medical School have created a combination drug that controls both tumor growth and metastasis. By combining a COX-2 inhibitor, similar to Celebrex, and an epoxide hydrolase (sEH) inhibitor, the drug controls angiogenesis (blood vessel formation), limiting a tumor’s ability to grow and spread. The study appears today in the journal Proceedings of the National Academy of Sciences.

Bruce Hammock Bruce Hammock

“We’ve been studying the effects of COX and sEH inhibitors, both by themselves and in combination, for several years,” said senior author and UC Davis Distinguished Professor Bruce Hammock. “We were surprised to find that the dual inhibitor was more active than higher doses of each compound, either individually or together. By combining the two molecules into one we got much greater potency against several diseases and completely unique effects in terms of blocking tumor growth and metastasis.”

Both COX and sEH enzymes control lipid signaling, which has long been associated with inflammation, cell migration, proliferation, hypertension and other processes. COX inhibitors block production of inflammatory and pain-inducing lipids, while sEH inhibitors preserve anti-hypertensive, anti-inflammatory and analgesic compounds. Separate COX and sEH inhibitors were previously found to work together in reducing inflammation and neuropathic pain. 

After testing individual COX-2 and sEH inhibitors, the team synthesized the drug (PTUTB), the first combined COX-2/sEH inhibitor. They then tested the dual inhibitor against human lung and breast tumors, both in vitro and in mice. They found that PTUTB blocked angiogenesis, inhibiting the proliferation of endothelial cells, which are critical to blood vessel formation. This in turn limited tumor growth and metastasis, reducing lung and breast tumor growth by 70 to 83 percent.

In breast and lung cancers, the dual inhibitor blocked angiogenesis, which blocked the growth of solid tumors,” said Hammock. “This represents a new mechanism to control blood vessel and tumor growth.”

Robert Weiss, a co-author and professor of nephrology at UC Davis, added that the combination drug achieved the results with minimal side effects and no cardiovascular or gastrointestinal effects.

“This is particularly important when administering COX-2 inhibitors, which have well-known cardiovascular risks,” he said. “However, the added sEH inhibitor appears to block COX-2’s side effects.”

The research was initiated by first author Guodong Zhang when he was a postdoctoral fellow in the Hammock laboratory. Zhang previously demonstrated that sEH inhibitors improve the power of omega-3 fatty acid (fish oil) diets to reduce tumor growth and metastasis, and implicated epoxides of the dietary supplement DHA as the causative agent.

By advancing a new anti-angiogenic compound, the study extends the work of renowned Harvard Medical School physician and researcher Judah Folkman, who illuminated the importance of angiogenesis to tumor growth, inspiring a new class of anti-cancer drugs. Two of the study’s authors, Dipak Panigrahy and Mark Kieran, previously worked with Folkman at Harvard Medical School.

Though the research was focused exclusively on cancer, researchers said the dual compound could benefit other conditions, such as macular degeneration.

“If we move beyond cancer, this drug combination could block a number of pathologies, ranging from cardiac hypertrophy to neuropathic pain,” said Hammock. “The compound looks quite powerful for a number of conditions.”

The research teams are continuing their work on several fronts.

“One member of our research team already has made more potent inhibitors with more drug-like properties,” Hammock said. “We are looking at the molecules for a variety of indications alone and in combination, including for kidney disease, fibrotic diseases, pancreatic and colon cancer and other problems.” The molecules are patented by the University of California and are available for license and testing.

Co-author Jun-Yan Liu, who performed the analytical chemistry for the study while a postgraduate researcher at UC Davis, is now examining the efficacy of the compounds in kidney disease and gout at a laboratory in the Shanghai Tenth Peoples Hospital.

“One of the most exciting things about this project was the ability to work with experts in multiple fields to find new drug class and new mechanism that promises to actually help people with cancer,” Liu said.   

Other researchers included: Sung Hee Hwang, Jun Yang, Lisa M. Mahakian, Yanru Wang, Elizabeth S. Ingham, Sarah Tam, Robert H. Weiss and Katherine W. Ferrara, all of UC Davis, and Hiromi I. Wettersten, formerly of UC Davis and now at UC San Diego.

The research was supported by NIEHS R01 ES02710, Superfund P42 ES04699, NIH/NIOSH U54 OH07550, R01 CA134659, R01 CA112356, R01 CA103828, NIH contract HHSN268201000043C, Research Investments in the Sciences and Engineering (RISE) Program of UC Davis, R01 CA148633, R01 CA135401, R01 DK082690, the Stop and Shop Pediatric Brain Tumor Fund, the C.J. Buckley Pediatric Brain Tumor Fund, the Medical Service of the US Department of Veterans Affairs and the American Asthma Society.

UC Davis Comprehensive Cancer Center
UC Davis Comprehensive Cancer Center is the only National Cancer Institute-designated center serving the Central Valley and inland Northern California, a region of more than 6 million people. Its specialists provide compassionate, comprehensive care for more than 10,000 adults and children every year, and access to more than 150 clinical trials at any given time. Its innovative research program engages more than 280 scientists at UC Davis, Lawrence Livermore National Laboratory and Jackson Laboratory (JAX West), whose scientific partnerships advance discovery of new tools to diagnose and treat cancer. Through the Cancer Care Network, UC Davis collaborates with a number of hospitals and clinical centers throughout the Central Valley and Northern California regions to offer the latest cancer care. Its community-based outreach and education programs address disparities in cancer outcomes across diverse populations. For more information, visit cancer.ucdavis.edu.

Office of the Vice Chancellor and Dean | UC Davis Health

Welcome Dr. David Lubarsky to UC Davis Health!

David A. LubarskyUC Davis Chancellor Gary May has appointed David A. Lubarsky to the position of vice chancellor of human health sciences and chief executive officer of UC Davis Health, which includes the School of Medicine, the Betty Irene Moore School of Nursing, the 1,000-member physician practice group, and UC Davis Medical Center, a 627-bed acute-care hospital. Lubarsky will join UC Davis on July 2, 2018.

Lubarsky most recently served as the chief medical and systems integration officer with the University of Miami Health System, a position he has held since 2012. As a leader within the system, he has overseen the system’s four hospital and practice chief medical officers as well as patient safety and quality. In addition, he led the university’s self-insured malpractice program, which focuses on prevention, and patient and visitor services, including patient experience. During his tenure at the University of Miami, Lubarsky integrated programs to create system-wide consistent approaches to care and quality improvement, including a new central safety and quality office, a system-wide safety and quality governing board, a system-wide chief medical officer council, a system-wide infection control and antibiotic stewardship program, and a central PI and project management office.

"David brings to UC Davis broad experience and proven results in a major healthcare market," May said. "He has an impressive record of sound financial management and innovative practices for a high functioning health care system that has gained national attention. His success in raising funds to meet pressing needs, including for enhanced access to Medicaid and indigent patients, aligns well with our values at UC Davis Health."

Lubarsky has been recognized for his success in helping establish a centralized scheduling system, improving infrastructure, and improving performance across many areas of the University of Miami health system. He raised more than $100 million annually for the University of Miami from state and federal funding sources to aid enhanced access for Medicaid and indigent patients. Previously, as CEO of the 1,100-physician practice, he turned a $100 million loss into a $32 million surplus in one year by growing patient volumes and optimizing the revenue cycle while making sure already high patient experience scores were maintained. Of note, every one of his major initiatives has explicitly prioritized quality and empathetic patient care.

In his efforts to meet community needs, Lubarsky has worked with the state of Florida and Centers for Medicare & Medicaid Services to expand access to Medicaid, forging a close partnership with the other major academic centers in Florida in pursuit of this goal. He has also been working with Florida’s state and congressional representatives to expand existing graduate medical education programs that would best meet the state’s needs and to secure the necessary federal funding which has been frozen for more than 20 years.

For the last 16 years, Lubarsky has been chief of service of anesthesia and pain management for the largest safety net hospital in the U.S., Jackson Memorial Hospital. He served on their board overseeing safety and quality, and throughout his tenure has been a forceful advocate for a uniform high quality of care.

"It is a privilege to join this highly regarded, progressive and nationally recognized health system," Lubarsky said. "I look forward to working closely with the accomplished faculty and staff, and routinely interacting with Davis’ talented students and trainees. I have already heard many great ideas about how to catapult Davis to greater heights, and I hope to harness those ideas to catalyze innovation so that we better serve our patients, our local community and our academic mission."

UC Davis School of Medicine is one of the nation's leading medical schools, recognized for its research and primary-care programs. Ranked 34th in National Institutes of Health funding in 2013, it is designated as one of the nation’s inaugural Clinical Translational Science Centers.

A few highlights include:

  • A national reputation for life-changing biomedical discoveries
  • A passion for clinical care and a commitment to engaging people from underserved communities and advancing rural health
  • Fully accredited master’s degree programs in public health and in informatics
  • A combined M.D.-Ph.D. program that is training the next generation of physician-scientists to conduct high-impact research and translate discoveries into better clinical care

The Dean’s Departments and Offices include:

Additional departments:

To learn more, visit the medical school site.

UC Davis Medical Center, based in Sacramento, Calif., is a nationally renowned academic medical center where clinical practice, teaching and research converge to advance human health.

A few highlights:

  • A 627-bed multispecialty academic medical center
  • Serves 33 counties covering a 65,000-square-mile area north to the Oregon border and east to Nevada
  • Recognized as one of the “Most Wired” hospitals in the U.S.
  • Recognized by The Leapfrog Group as a “Top Hospital” for delivery of high-quality care
  • Ranked Sacramento's top hospital by U.S. News & World Report

Centers of excellence include:

  • UC Davis Comprehensive Cancer Center, one of only 41 National Cancer Institute-designated comprehensive centers nationwide
  • State-of-the-art emergency departments that include the region's only Level I adult and pediatric trauma centers
  • The internationally recognized UC Davis MIND Institute, devoted to finding treatments and cures for neurodevelopmental disorders
  • UC Davis Children's Hospital, a nationally ranked pediatric hospital with more than 120 physicians in 33 pediatric subspecialties
  • A pioneering telehealth program, which gives remote, underserved communities access to academic specialty and subspecialty care

To learn more, visit the medical center site.

The Betty Irene Moore School of Nursing at UC Davis cultivates academic excellence and addresses urgent, societal needs through leadership development, interprofessional education, transformative research, cultural inclusiveness and innovative technology. The school plays a critical role in preparing nurse leaders who will shape the future of health care and inform health policy.

The School of Nursing has five research focus areas: chronic disease management, health technology, pain management, Healthy People and Healthy Systems. Faculty come from a wide range of backgrounds including nursing, business administration, sociology, gerontology, medicine, information technology and psychology. School of Nursing students engage in classroom and clinical environments with students in the School of Medicine, health informatics and other health-related programs.

A few highlights include:

To learn more, visit the School of Nursing’s website.

The Practice Management Group (TPMG) represents all organized medical group practices of UC Davis Health System’s primary and specialty care faculty physicians. The group's purpose is to serve the health system’s missions through high-quality, cost-effective care delivery. By delegation from the Office of the Vice Chancellor and Dean, TPMG has shared responsibility for the clinical operations of the health system's professional practice activities.

The formation of TPMG is an important step in formalizing the leadership of the health system's medical group practices and in refining the role of its group practice in achieving the health system's research, teaching, patient care and community engagement goals. Its primary goal is to maintain a clinical practice that distinguishes UC Davis Health System as a leading faculty and academic health center.

Specific goals of TPMG include:

  • Increasing efficiency of practice and revenue
  • Decreasing practice expenses
  • Reducing silos and improving integration
  • Identifying areas to increase quality
  • Aligning incentives

David H. Wisner is the executive director of the Practice Management Group, overseeing faculty practice operations as well as the overall vision and strategic direction of TPMG and its day-to-day activities. Wisner collaborates with the leadership of the School of Medicine and medical center to set and achieve joint strategic goals across the health system.

More information