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November 2017arrow

UC study finds performance on med school interviews linked to demographics

November 21, 2017

The medical school interview – a key determinant in the admissions process and, ultimately, in the physician workforce – appears to skew for or against applicants depending on their age, gender and self-identified disadvantaged socioeconomic status.

Maternal immune response affects genes in microglia, neural development

November 20, 2017

UC Davis MIND Institute esearchers have shown in a mouse model that an elevated maternal immune response changes the epigenetic landscape in offspring’s microglia, immune cells found in the brain and spinal cord. These changes affect genes associated with immune signaling and neural development, some of which have been implicated in autism spectrum disorder (ASD). The study was published online in the journal Glia.

In cancer, talking about bad news can be good

November 17, 2017

Giving bad news is never easy, especially when it’s life or death. But when an oncologist delivers a poor prognosis to a cancer patient, does it harm their relationship?  Some research studies have suggested it can.

Unlocking the genetics of cancer

November 7, 2017

For many, breast cancer is more than just a disease – it’s personal. One in eight women will be diagnosed with breast cancer at some point in their lives. But through new discoveries at the genetic level, the personal nature of cancer will eventually be what helps to beat it.

October 2017arrow

Peers can reduce tobacco use among younger smokers

October 25, 2017

Participating in a brief intervention delivered by their peers in community settings can help reduce smoking among youth and young adults, a new study from a team of tobacco-cessation researchers shows.

MIND Institute researchers detect reversal of behavioral deficits in a rare genetic disorder

October 23, 2017

Research conducted in mice at the UC Davis MIND Institute suggests that a drug treatment can reverse cognitive deficits and social abnormalities in a rare genetic disorder, 16p11.2 deletion syndrome, which includes symptoms of intellectual disability and autism spectrum disorder, among others. Results of parallel studies conducted at the MIND and at the Massachusetts Institute of Technology Picower Institute for Learning and Memory appear in the latest issue of the journal Neuropsychopharmacology.

Moonshot grant advances immune therapy for dogs - and one day people - with cancer

October 20, 2017

UC Davis has received its first National Cancer Institute (NCI) Moonshot grant  ̶  $2.5 million over five years  ̶  to explore immunotherapy treatments for dogs who develop melanoma and osteosarcoma and that may one day benefit humans, as well.

Cancer Center hosts lung cancer research conference

October 19, 2017

Members of the UC Davis Comprehensive Cancer Center lung cancer treatment team will present at WCLC 2017, a one-day conference on Saturday, Nov. 11, from 7 a.m. to 4 p.m. in San Francisco. Presenters will share the latest lung cancer and other thoracic malignancy advances highlighted at the recent 18th Annual World Conference on Lung Cancer in Japan.

Noncompliance thwarts comprehensive background check policy for private-party sales, study finds

October 9, 2017

Of the three states that recently expanded comprehensive background check (CBC) policies to include all gun transfers, including those among private parties, only Delaware showed an overall increase in firearm background checks. Washington and Colorado had no changes, which the study authors say suggests that compliance and enforcement were incomplete.

"Smart" immune cells: Emerging cancer therapy research at UC Davis receives a boost with NIH award

October 6, 2017

Assistant Professor Sean Collins, Department of Microbiology and Molecular Genetics, has received a $1.5 million award from the National Institutes of Health to advance the development of “smart” immune cells for therapies to treat cancer and other diseases. The five-year NIH Director’s New Innovator Award aims to provide new insight into how to engineer immune cells to control their recruitment and response to tumors.

September 2017arrow

UC Davis receives $8 million to expand access to stem cell clinical trials

September 28, 2017

The California Institute for Regenerative Medicine today awarded a nearly $8 million grant to University of California, Davis, stem cell researchers to launch a special clinical trials program in Sacramento to accelerate the therapeutic development and delivery of stem cell therapies in human patients.

$3.3 million grant funds early detection of pancreatic cancer

September 27, 2017

UC Davis researchers, led by Julie Sutcliffe, have received a $3.3 million grant from the National Institutes of Health to advance efforts to diagnose pancreatic cancer before it spreads.

Too little is known about the compounds in wildfire smoke

September 25, 2017

How do fire-suppression chemicals and pesticides affect wildfire smoke and the health of those who breathe it? UC Davis graduate students discovered that this question cannot be answered based on current scientific evidence and, in a review published in Current Topics in Toxicology, they recommend more studies on the compounds in wildfire smoke.

UC Davis MIND Institute wins coveted ACE grant

September 7, 2017

The UC Davis MIND Institute has been awarded a 5-year, $12 million Autism Centers of Excellence (ACE) grant, one of five in the nation, to create a “Center for the Development of Phenotype-based Treatments of Autism Spectrum Disorder.”

August 2017arrow

Knoepfler awarded second Alex's Lemonade Stand research grant

August 30, 2017

UC Davis stem cell scientist Paul Knoepfler has been awarded a second $250,000 grant for glioma research from an organization begun 15 years ago by a 5-year-old girl with a deadly form of childhood cancer.

Stem cell treatment for children with spina bifida helps dogs first

August 24, 2017

A pair of English bulldog puppies are the first patients to be successfully treated with a unique therapy — a combination of surgery and stem cells — developed at the University of California, Davis, to help preserve lower-limb function in children with spina bifida.

Before sarcoma surgery - radiation

August 18, 2017

UC Davis researchers have shown that radiation therapy before surgery improves overall survival for patients with soft tissue sarcomas. This pre-surgical, or neoadjuvant, radiotherapy allows surgeons to get better margins around tumors and remove even microscopic cancer tissue more often. The study was published recently  in the Annals of Surgical Oncology.

Study of California kidney cancer shows declining incidence, end of a trend

August 18, 2017

A review of kidney cancer in California from 1988 through 2013 by the UC Davis Institute for Population Health Improvement (IPHI) has concluded that the high incidence of small tumors and early-stage disease observed in California from 1988 until about 2009 has declined and stabilized in recent years, signaling the end of a trend.

Impulsivity in teens, young adults subject of $3.7 million UC Davis grant

August 11, 2017

Julie Schweitzer, a professor in the Department of Psychiatry and Behavioral Sciences and UC Davis MIND Institute researcher, has received a $3.7 million grant from the National Institute of Mental Health (NIMH) to track impulsivity and self-control in teens and young adults over time.

July 2017arrow

Health plans that shared best practices improved hypertension control for low-income Californians

July 31, 2017

Health plans that collaborated to share best practices and successful strategies for treating patients diagnosed with hypertension saw significant improvement in controlling high blood pressure, a study by the California Department of Health Care Services (DHCS) and UC Davis Institute of Population Health Improvement (IPHI) has found.

Med student focusing on brain research awarded 2017 O'Connor research grant

July 28, 2017

John Paul Aboubechara, a fifth-year student in the combined M.D./Ph.D. program at UC Davis School of Medicine, has been honored with this year’s Daniel T. O’Connor, M.D., Memorial Research Grant.

Massive study launched to test personalized approach to breast cancer screening

July 26, 2017

Sorting out when or whether to get mammograms can be perplexing for any woman, and a health provider’s advice may not settle the matter. That’s because even experts disagree about when screening mammography is appropriate and for whom.

UC Davis to lead $14 million Alzheimer's disease study in Latinos

July 25, 2017

The University of California has been awarded a nearly $14.7 million multi-year grant from the National Institutes of Health to study contributors to dementia in the Latino population in the United States. The multicenter study will examine the biological underpinnings of stroke, mild cognitive impairment and Alzheimer’s disease among Hispanics, and pursue new therapeutic directions to reduce brain health disparities.  

UC Firearm Violence Prevention Research Center launched at UC Davis

July 24, 2017

The University of California Firearm Violence Research Center at UC Davis’ Sacramento campus officially launched July 4 under the direction of Garen Wintemute, a professor of emergency medicine and recognized authority on the epidemiology of firearm violence. 

Clinical trial shows some promise for Duchenne muscular dystrophy drug

July 18, 2017

The results of an international clinical trial, led in part by a UC Davis School of Medicine expert, have shown that a drug therapy for a severe type of muscular dystrophy holds promise for a subgroup of patients.

Kuppermann gets award of a lifetime

July 14, 2017

The Society for Academic Emergency Medicine (SAEM) recently honored Nate Kuppermann with more than just a lifetime award for meritorious accomplishments in research and mentorship.

Chronic liver inflammation linked to Western diet, mouse study finds

July 12, 2017

A new study published today in The American Journal of Pathologyfound  that mice fed a high-fat, high-sugar Western diet developed hepatic inflammation, which was more common in males than females and most pronounced in mice that also lacked a bile acid receptor known as farnesoid x receptor, or FXR.

Life-saving Umbilical Cord Blood Collection Program extended 5 years

July 11, 2017

In a decisive move by the Governor and Legislature, the University of California Umbilical Cord Blood Collection Program (UCBCP) has been extended through 2022. The program enables mothers of newborns to donate their babies’ umbilical cord blood and have it publicly banked so it is available to anyone for lifesaving transplantations.

UC Davis physician honored for Huntington's disease work

July 10, 2017

The Northern California chapter of Huntington’s Disease Society of American (HDSA) has honored UC Davis Health’s Lorin Scher for his outstanding service to the Huntington’s disease community in the Sacramento region.

June 2017arrow

UC Davis Health, Sacramento Fire partnering to improve emergency care for children

June 28, 2017

UC Davis Health and the Sacramento City Fire Department have established a research partnership that aims to improve care for sick and injured children during and after an emergency transport.

Researchers validate mouse model for autism

June 22, 2017

Researchers at the UC Davis MIND Institute and Boston Children’s Hospital have confirmed that mice without the Shank3B protein model aspects of brain physiology and behavioral symptoms observed in people with autism. The findings confirm that Shank3B knockout mice provide a valuable research tool for future efforts to develop new therapies. The study, supported by Autism Speaks, was published in the journal Molecular Autism.

Study debunks claim of greatly improved survival rate for gunshot victims

June 22, 2017

The survival rate of U.S. gunshot victims has not shown a marked improvement, as other recent studies have suggested, according to new research from Duke University and the University of California, Davis.

Ultrasound for children with abdominal trauma

June 13, 2017

Despite evidence showing that the routine use of sonography in hospital emergency departments can safely improve care for adults when evaluating for possible abdominal trauma injuries, researchers at UC Davis Medical Center could not identify any significant improvements in care for pediatric trauma patients.

How treating a dog's tumors may help in the fight against human cancer

June 6, 2017

With its internationally renowned school of veterinary medicine and its NCI-designated comprehensive cancer center, UC Davis is uniquely positioned to harness the power of each to tackle one of life’s greatest challenges: cancer.

How gender, diet, microbiota and molecules contribute to metabolic disease and liver cancer

June 6, 2017

Researchers at UC Davis Health and other institutions have shown that gender differences in mice microbiota can modulate the risk of developing metabolic disease and liver cancer. In addition, the team found that a bile acid receptor protein, called FXR, has a profound impact on mouse microbiota and bile acid profiles and is differentially expressed based on gender. The study was published in the journal Scientific Reports.

May 2017arrow

UC Davis signs agreement to license novel CT scanning technology

May 24, 2017

UC Davis has signed a licensing agreement providing Isotropic Imaging Corporation the rights to commercialize a novel computed tomography (CT) scanner that has the potential to improve breast cancer detection and positively impact women’s health.

UC Davis Duchenne team honored by national parent organization

May 5, 2017

The UC Davis Neuromuscular Research Center has been recognized as a Certified Duchenne Care Center by Parent Project Muscular Dystrophy for national leadership in treating Duchenne muscular dystrophy.

April 2017arrow

Less is best when treating burn patients with blood transfusions

April 26, 2017

Reducing by half the typical amount of blood provided through transfusions to burn patients makes no difference in terms of patient outcomes, a new multi-center study led by UC Davis researchers shows.

Early cancer deaths linked to being single, living in a poor neighborhood

April 25, 2017

Patients in California hospitals were more likely to die within 60 days of being diagnosed with acute myeloid leukemia – a cancer of the blood and bone marrow – if they were unmarried, lived in a less-affluent neighborhood or lacked health insurance. The UC Davis study also found that patients treated at a National Cancer Institute (NCI)-designated cancer center were more likely to survive.

Second cancers deadlier in young patients

April 20, 2017

Second cancers in children and adolescents and young adults (AYA) are far deadlier than they are in older adults and may partially account for the relatively poor outcomes of cancer patients ages 15-39 overall, a new study by UC Davis researchers has found.

Improving outcomes for adults with autism spectrum disorder

April 7, 2017

Adults with autism spectrum disorder (ASD) will be the topic of the next Minds behind the MIND lecture on April 19 at 5:30 p.m. at the UC Davis MIND Institute, 2825 50th St. in Sacramento. The lecture is free and open to the public.

March 2017arrow

Hitting cancer with high-intensity ultrasound and immunotherapy

March 23, 2017

In a new study published today in JCI Insight, UC Davis researchers have shown that combining high-intensity focused ultrasound with two immunotherapies (a PD-1 checkpoint inhibitor and TLR9 agonist) can produce excellent response rates in mouse models of epithelial cancer. They also found that, for the combination to be effective, immunotherapies must come first.

UC Davis researchers investigate adult blood-clotting drug for use in severely injured children

March 14, 2017

UC Davis emergency medicine researchers have been awarded a grant from the National Institutes of Health (National Heart, Lung, and Blood Institute) to investigate the safety and efficacy of a drug known to stop bleeding in injured adults for use in cases of pediatric trauma.

How H. pylori thrives in the highly acidic stomach

March 9, 2017

An international team of reseachers led by Thomas Borén at Umeå University and including Jay Solnick, professor internal medicine at UC Davis, has discovered the tmechanism that gives the bacteria such staying-power and ability to cause chronic infection.

Developing new collaborations and technologies

March 7, 2017

With a $1 million grant from the National Science Foundation (NSF), UC Davis and Boston University will focus on establishing partnerships with industry, academe and government that lead to the development of innovative biophotonic technologies for use in medicine and other scientific disciplines.

University of California, Stanford partner on research to improve health in California and nationwide

March 7, 2017

The University of California Biomedical Research Acceleration, Integration, and Development program (UC BRAID) and Stanford University have formed an alliance to combine resources and develop a coordinated approach to research targeting the health of Californians – a partnership that can serve as a model for collaborations throughout the country.

UC Davis joins national consortium to find regenerative treatments for dental and craniofacial tissues

March 7, 2017

UC Davis will join other California research institutions in a three-year, $12 million effort to find regenerative treatments for dental, oral and craniofacial deformities and injuries.

Doctors and patients often disagree on pain treatment goals

March 6, 2017

Disagreements between doctors and patients over the priorities of pain treatment are common during primary care office visits, new research from UC Davis Health shows. Patients hope to reduce pain intensity and identify the cause, while physicians aim to improve physical function and reduce medication side effects, including dependency.

Cerebrospinal fluid shows promise as autism biomarker

March 6, 2017

Researchers from the UC Davis MIND Institute, University of North Carolina (UNC) and other institutions have found that altered distribution of cerebrospinal fluid (CSF) in high-risk infants can predict whether they will develop autism spectrum disorder (ASD). The study appears today in the journal Biological Psychiatry.

February 2017arrow

UC Davis computational molecular biologist named Sloan fellow to study genetic causes of complex disorders

February 27, 2017

Fereydoun Hormozdiari, an early-career UC Davis scientist, has been named a 2017 Alfred P. Sloan Research Fellow in Computational & Evolutionary Molecular Biology. He is one of 126 scholars to receive the prestigious award, which comes with $60,000 over two years to conduct leading-edge research.

Research linking obesity to immune function and disease gets funding boost

February 23, 2017

Researchers at UC Davis have received $3.2 million in federal funds to further investigate how obesity and inflammation affect the body’s immune system in fighting cancer.

Placenta provides time capsule for autism studies

February 21, 2017

In two recent studies, researchers at UC Davis have shown that the placenta can provide critical information about early changes to the intra-uterine environment that may influence fetal development and ultimately, children’s brains.

Language barriers may interfere with access to kidney transplantation

February 10, 2017

Language barriers may hinder U.S. kidney transplant candidates’ access to kidney transplantation, according to a new study in the Clinical Journal of the American Society of Nephrology.  Led by a team from Cedars-Sinai, UCLA Health and UC Davis Health, the research suggests that patients who primarily speak a language other than English may face disparities that keep them from completing their kidney transplant evaluations and, ultimately, from receiving a transplant.

Poverty and high neighborhood murder rates increase depression in older adults

February 9, 2017

Older adults who live in poor and violent urban neighborhoods are at greater risk for depression, a study by researchers from UC Davis, the University of Minnesota and other institutions published Jan. 23 in the journal Health & Place has found.

UC Davis study finds mold, bacterial contaminants in medical marijuana samples

February 7, 2017

UC Davis physician researchers have found that medical marijuana contains multiple bacterial and fungal pathogens that may cause serious and even fatal infections. They warn that smoking, vaping or inhaling aerosolized marijuana could pose a grave risk to patients, especially those with leukemia, lymphoma, AIDS or conditions requiring immune-suppressing therapies.

January 2017arrow

How maternal immune response to allergies may affect neurodevelopment

January 31, 2017

Researchers at UC Davis have published a study that illustrates how maternal immune activation could affect neurodevelopment in offspring.

Prior DUIs predict future criminal activity among firearm owners

January 30, 2017

Among individuals who legally purchased handguns in California, prior convictions for driving under the influence (DUI) and other alcohol-related crimes were associated with a substantial increase in risk for subsequent violent or firearm-related crime, according to a study published Jan. 30 in Injury Prevention by the UC Davis Violence Prevention Research Program.

Faulty DNA error correction genes set stage for familial gastric cancer

January 19, 2017

A large team of researchers from UC Davis and several European and Latin American institutions have identified genetic variations that contribute to familial gastric cancer. These inherited mutations, which affect the PALB2, BRCA1 and RAD51C genes and have been implicated in other cancer types, impair a critical DNA repair mechanism called homologous recombination. These findings could improve preventive care, as well as provide targets for new therapies. The study was published last month in the journal Gastroenterology.

Many late-stage lung cancer patients do not get treatment

January 18, 2017

A national study by researchers at UC Davis Comprehensive Cancer Center has found that a significant number of lung cancer patients are not receiving treatment. Based on data between 1998 and 2012 from the National Cancer Database, 21 percent of patients (190,539) with non-small cell lung cancer (NSCLC) received no specific cancer treatment, such as chemotherapy, radiotherapy or surgery. Many of the untreated patients were women, elderly, minorities, low income and uninsured.

UC Davis Health welcomes Beijing medical equipment company

January 9, 2017

UC Davis Health has entered into an agreement with Top Grade Health Care to establish a translational research and development center to advance the treatment of patients with cancer.

December 2016arrow

UC Davis MIND Institute part of national study on video game-like therapy for ADHD

December 28, 2016

The UC Davis MIND Institute is participating in a nationwide ADHD study using a scientifically designed video game-like technology.

Shift in some teens' use and perceptions of marijuana after recreational marijuana is legalized

December 27, 2016

Marijuana use significantly increased and its perceived harm decreased among eighth- and 10th-graders in Washington state following enactment of recreational marijuana laws, according to a UC Davis and Columbia University Mailman School of Public Health to be published online in JAMA Pediatrics. There was no change in use or perceived harm among 12th graders or among similar grades in Colorado.

Genomic sequencing illuminates recent Shigella outbreaks in California

December 22, 2016

In a study that could have significant impact on how disease outbreaks are managed, researchers at UC Davis and the California Department of Public Health (CDPH) have sequenced and analyzed genomes from Shigella sonnei (S. sonnei) bacteria associated with major shigellosis outbreaks in California in 2014 and 2015.

Study identifies who could benefit most from exercise as a depression treatment

December 21, 2016

Factors such as advanced age and greater aerobic capacity increase the likelihood that exercise will work as a treatment for depression in elderly patients, a recent study published in the Journal of the American Geriatrics Society has shown.

UC program excels at reducing hospital blood clots

December 15, 2016

Results of a UC-wide venous thromboembolism (VTE) prevention program, led by Gregory Maynard, chief quality officer for UC Davis Medical Center, have shown a significant reduction in hospital-associated VTEs at all five participating UC hospitals, according to a recently released study authored by Maynard and published in the December 2016 issue of the Journal of Hospital Medicine.

Fragile X drug trial gets $11.5 million in NIH funding

December 15, 2016

The UC Davis MIND Institute and Rush University Medical Center have been awarded $11.5 million from the National Institutes of Health to test a new therapy designed to improve language learning for children fragile X syndrome. 

Hormonal contraception is safer than expected for women with diabetes

December 14, 2016

Strokes and heart attacks are rare for women with diabetes who use hormonal contraception, with the safest options being intrauterine devices (IUDs) and under-the-skin implants, new research published in Diabetes Care shows.

Genetics and environment combine to influence autism-associated genes

December 13, 2016

Researchers at UC Davis have shown that a well-known neurotoxin (PCB 95) and a chromosomal duplication (Dup15q) have a profound impact on DNA methylation, the epigenetic process that can influence gene activity. These cumulative genetic and environmental “hits” alter the epigenetic landscape during development, altering genes linked to autism spectrum disorder (ASD). The study was published in the journal Cell Reports.

Immunotherapy improves survival in late-stage lung cancer patients

December 12, 2016

A large trial by UC Davis professor David Gandara has found that the immunotherapy atezolizumab was superior to chemotherapy for patients with advanced non-small-cell lung cancer.

Healthy weight only protects women from hot flashes during the early stages of menopause

December 6, 2016

Greater weight increases the likelihood of hot flashes and night sweats during early stages of the menopause transition but reduces those symptoms throughout menopause and beyond, new UC Davis research published in the journal Menopause shows.