The U.S. Department of Defense has awarded $2 million to David Greenhalgh, a UC Davis surgeon and national leader in treating burn injuries, for a study of the outcomes of a fluid resuscitation treatment for burn patients.
The four-year, multi-center Acute Burn Resuscitation Observational Trial, known as ABRUPT, will evaluate detailed information on the use of albumin, a serum of blood plasma proteins used to restore blood flow and respiration during burn shock, a common complication and cause of death following burn injury.
Greenhalgh is chief of burn surgery at Shriners Hospitals for Children – Northern California and the Firefighters Burn Institute Regional Burn Center at UC Davis Medical Center, where he leads a collaborative treatment and research team that cares for thousands of children and adults throughout California.
“There has been debate for decades over what is the proper timing and dosage of albumin in patients with severe burn injuries,” Greenhalgh said. “ABRUPT will provide solid data to support — or dispute — the hypothesis that earlier administration of albumin results in an overall reduction in the amount of abnormal swelling in burn patients and, in turn, fewer respiratory complications.”
The study involves 20 burn centers throughout North America and will enroll 366 patients over the age of 18 who are admitted to a burn center within 12 hours following an injury that affects 20 percent or more of their total body surface.
Data will be collected through the Data Collection Center of the American Burn Association at UC Davis.
A Center of Excellence, the Firefighters Burn Institute Regional Burn Center unites the exceptional surgical, critical care and rehabilitation resources of UC Davis to care for the unique needs of adult burn patients. The team also treats pediatric burn patients through a partnership with Shriners Hospitals for Children – Northern California. In addition to a comprehensive clinical program, the burn center conducts research aimed at speeding recovery and improving patient outcomes, leads community outreach to support burn survivors and provides education to reduce burn injuries.