Christopher L. Bowlus, M.D.

Clinical/Research Interests

Christopher L. Bowlus specializes in liver diseases, specifically hemochromatosis and other iron overload syndromes. He is interested in immunologic diseases of the liver, including primary biliary cirrhosis, primary sclerosing cholangitis, autoimmune hepatitis, and transplant rejection. His research interests are aimed at elucidating the causes of liver disease. Bowlus is studying the immune system within the thymus and how abnormal development may lead to autoimmune disorders.

Title:

Associate Professor, Fellowship Program Director, Gastroenterology

Specialty:

Gastroenterology and Hepatology, Internal Medicine

Address:

UC Davis Medical Center
2315 Stockton Blvd.
Sacramento, CA 95817

Phone:

(916) 734-0779

Education:

St. Louis University School of Medicine
St. Louis, Missouri
M.D. 1990

Internships:

University of California, Davis Medical Center
Sacramento, California
1990-93

Residency:

University of California, Davis Medical Center
Sacramento, California
1990-93
Internal Medicine

Fellowships:

Yale University, School of Medicine
New Haven, Connecticut
1993-96
Gastroenterology and Hepatology

Board Certifications:

American Board of Internal Medicine, Gastroenterology, 2009
American Board of Internal Medicine, 1993

Honors and Awards:

American Liver Foundation, Postdoctoral Fellowship Award, 1994

Select Recent Publications:

Moritoki Y,Zhang W, Tsuneyama K, Yoshida K, Wakabayashi K, Yang GX, Bowlus C, Ridgway WM, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Flavell RA, Gershwin ME, Lian Zx. B cells suppress the inflammatory response in a mouse model of primary bilie-y cirrhosis. Gastroenterology. 2009 Mar; 136(3): 1037-47

Aron JH, Bowlus CL. The immunobiology of primary sclerosing cholangitis. Semin Immunopathol. 2009 Sep;31 (3):383-97.

Selmi C, Zuin M, Bowlus CL, Gershwin ME. Anti-mitochondrial antibody-negative primary biliary cirrhosis. Clin Liver Dis. 2008 Feb;12(1): 173-85, ix.

Selmi C, Gershwin ME, Lindor KD, Worman HJ, Gold EB, Watnik M, Utts J, Invernizzi P, Kaplan MM, Vierling JM, Bowlus CL, Silveira MG, Bossi I; USA PBC Epidemiology Group. Quality of life and everyday activities inpatients with primary biliary cirrhosis. Hepatology. 2007 Dec;46(6): 1836-43

Bowlus CL, Karlsen TH, Broome U, Thorsby E, Vatn M, Schrumpf E, Lie BA, Boberg KM. Analysis of MAdCAM-1and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. J Hepato!. 2006 Nov;45(5):704-10.

Aoki CA, Dawson K, Kenny TP, Gershwin ME, Bowlus CL. Gene expression by PBMC in primary sclerosing cholangitis:evidence for dysregulation of immune mediated genes. Clin Dev Immuno!. 2006 Jun-Dec; l3(2-4):265-71

Tallkvist J, Bowlus CL, Lönnerdal B. Functional and molecular responses of human intestinal Caco-2 cells to iron treatment. Am J Clin Nutr 2000 72: 770-775.

Bowlus CL, Ahn J, Chu T, Gruen JR. Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. Cellular Immunology, 1999, 196(2):80-6.

Goei VL, Choi J, Ahn J, Bowlus CL, Raha-Chowdhury R, Gruen JR. Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization. Biological Psychiatry, 1998, 44(8):659-66.

Gruen JR, Nalabolu RS, Chu TW, Bowlus C, Fan WF, Goiei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM. A transcription map of the major histocompatibility comples (MHC) class I region Gemonics 1996;36(1):70-85

To see if Christopher L. Bowlus is accepting new patients, or for assistance finding a UC Davis doctor, please call (800) 2-UC DAVIS.