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UC Davis Health System

Christopher L. Bowlus, M.D. View profile as PDF

Christopher L. Bowlus

Clinical Interests

Christopher L. Bowlus specializes in liver diseases, specifically hemochromatosis and other iron overload syndromes. He is interested in immunologic diseases of the liver, including primary biliary cirrhosis, primary sclerosing cholangitis, autoimmune hepatitis, and transplant rejection. His research interests are aimed at elucidating the causes of liver disease. Bowlus is studying the immune system within the thymus and how abnormal development may lead to autoimmune disorders.


Associate Professor
Fellowship Program Director, Gastroenterology


Gastroenterology and Hepatology, Internal Medicine


Internal Medicine


Gastroenterology and Hepatology


UC Davis Medical Group, Elk Grove


UC Davis Medical Center
2315 Stockton Blvd.
Sacramento, CA 95817
Driving Directions
Phone: 800-2-UCDAVIS (800-282-3284)

UC Davis Medical Group - Elk Grove
8110 Laguna Blvd.
Elk Grove, CA 95758
Driving Directions
Phone: 916-683-3955

Additional Phone:

Department Contact Phone: 916-734-0779
Physician Referrals: 800-4-UCDAVIS (800-482-3284)


M.D., St. Louis University School of Medicine, St. Louis, Missouri, 1990


University of California, Davis Medical Center, Sacramento, California, 1990-93


University of California, Davis Medical Center, Sacramento, California, 1990-93


Yale University, School of Medicine, New Haven, Connecticut, 1993-96

Board Certifications:

American Board of Internal Medicine, 1993
American Board of Internal Medicine, Gastroenterology, 2009

Select Honors and Awards:

American Liver Foundation, Postdoctoral Fellowship Award, 1994

Select Recent Publications:

Aron JH, Bowlus CL. The immunobiology of primary sclerosing cholangitis. Semin Immunopathol. 2009 Sep;31 (3):383-97.

Moritoki Y,Zhang W, Tsuneyama K, Yoshida K, Wakabayashi K, Yang GX, Bowlus C, Ridgway WM, Ueno Y, Ansari AA, Coppel RL, Mackay IR, Flavell RA, Gershwin ME, Lian Zx. B cells suppress the inflammatory response in a mouse model of primary bilie-y cirrhosis. Gastroenterology. 2009 Mar; 136(3): 1037-47

Selmi C, Zuin M, Bowlus CL, Gershwin ME. Anti-mitochondrial antibody-negative primary biliary cirrhosis. Clin Liver Dis. 2008 Feb;12(1): 173-85, ix.

Selmi C, Gershwin ME, Lindor KD, Worman HJ, Gold EB, Watnik M, Utts J, Invernizzi P, Kaplan MM, Vierling JM, Bowlus CL, Silveira MG, Bossi I; USA PBC Epidemiology Group. Quality of life and everyday activities inpatients with primary biliary cirrhosis. Hepatology. 2007 Dec;46(6): 1836-43

Bowlus CL, Karlsen TH, Broome U, Thorsby E, Vatn M, Schrumpf E, Lie BA, Boberg KM. Analysis of MAdCAM-1and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis. J Hepato!. 2006 Nov;45(5):704-10.

Aoki CA, Dawson K, Kenny TP, Gershwin ME, Bowlus CL. Gene expression by PBMC in primary sclerosing cholangitis:evidence for dysregulation of immune mediated genes. Clin Dev Immuno!. 2006 Jun-Dec; l3(2-4):265-71

Tallkvist J, Bowlus CL, Lönnerdal B. Functional and molecular responses of human intestinal Caco-2 cells to iron treatment. Am J Clin Nutr 2000 72: 770-775.

Bowlus CL, Ahn J, Chu T, Gruen JR. Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus. Cellular Immunology, 1999, 196(2):80-6.

Goei VL, Choi J, Ahn J, Bowlus CL, Raha-Chowdhury R, Gruen JR. Human gamma-aminobutyric acid B receptor gene: complementary DNA cloning, expression, chromosomal location, and genomic organization. Biological Psychiatry, 1998, 44(8):659-66.

Gruen JR, Nalabolu RS, Chu TW, Bowlus C, Fan WF, Goiei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM. A transcription map of the major histocompatibility comples (MHC) class I region Gemonics 1996;36(1):70-85

Bray-Ward P, Bowlus C, Choi J, Paslier DL, Weissenbach J, Gruen JR. FISH-Mapped CEPH YACs spanning 0 to 46 cM on human chromosone 6. Genomics 1996;36(1):104-111

Bowlus CL, McQuillan JJ, Dean DC. Characterization of three different elements in the 51-flanking region of the fibronectin gene which modulate a transcriptional response to cAMP Journal of Biological Chemistry 1991;266 (2):1122-1127

Dean DC, Bowlus CL Bourgeois S. Cloning and analysis of the promter region of the human fibronectin gene Proceedings of the National Academy of Science 1987;84:1876-1880

To see if Christopher L. Bowlus is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).