John C. Rutledge is an expert in atherosclerosis and lipid disorders. He specializes in preventive cardiology, lipid disorders and reversal of atherosclerotic cardiovascular disease.
Dr. Rutledge's current laboratory research includes biology of the vascular wall.
Vice Chair of Research, Internal Medicine
Richard A. and Nora Eccles Harrison Endowed Chair for Diabetes Research
4860 Y St., Suite 0200
Sacramento, CA 95817
B.A., University of Texas, Austin TX 1972
American Board of Internal Medicine, Cardiovascular Disease, 1985
American College of Cardiology, Fellow
American College of Physicians
American Federation of Clinical Research
American Heart Association, Fellow
Select Honors and Awards:
NIH Travel Award: The Intersection of Metabolic and Neurocognitive Function, NIH Workshop, NIH campus, July 17-18, 2015
Greater Bay Area Research Award Reception, Honoring AHA Northern California Research Awardees, 2011
Top Cited Article 2008-2010, Journal of Vascular Pharmacology, Altman R, Motton DD, Kota RS, Rutledge JC: Inhibition of vascular inflammation by DHEAS in human aortic endothelial cells: Roles of PPAR and NF-kB, 2010
Co-Chair, UC Davis School of Medicine Vice-Chairs for Research, 2011
Chair, Research Affairs Committee, UC Davis Center 2005-, 2013
Executive Council, UC Davis Academic Senate, 2005
Dean’s Excellence in Mentoring Award, UC Davis, 2000
Co-Chair, “Mouse Models of Diabetic Complications Consortium” Study Sect. Review, NIDDK, 2001
Richard A. and Nora Eccles Harrison Endowed Chair in Diabetes Research, 2000
Chair, Graduate Group in Physiology 1998-, 2001
Select Recent Publications:
To view a detailed list of Dr. Rutledge's publications, please click here.
Eiselein L, Nyunt T, Lamé MW, Ng KF, Wilson DW, Rutledge JC, Aung HH. TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGF-β Receptor Pathway in Human Aortic Endothelial Cells. PLoS One. 2015 Dec 28;10(12):e0145523.
Ng KF, Anderson S, Mayo P, Aung HH, Walton JH, Rutledge JC. Characterizing blood-brain barrier perturbations after exposure to human triglyceride-rich lipoprotein lipolysis products using MRI in a rat model. Magn Reson Med. 2015 Oct 20. [Epub ahead of print]
Walton JH, Ng KF, Anderson SE, Rutledge JC. MRI measurement of blood-brain barrier transport with a rapid acquisition refocused echo (RARE) method. Biochem Biophys Res Commun. 2015 Aug 7;463(4):479-82.
Yahiatène I, Aung HH, Wilson DW, Rutledge JC. Single-molecule quantification of lipotoxic expression of activating transcription factor 3. Phys Chem Chem Phys. 2014 Oct 21;16(39):21595-601.
Altman R, Keenan AH, Newman JW, Rutledge JC. The Postprandial Effects of a Moderately High-Fat Meal on Lipid Profiles and Vascular Inflammation in Alzheimer's Disease Patients: A Pilot Study. J Gen Pract (Los Angel). 2014;2(6). pii: 186.
den Hartigh LJ, Altman R, Norman JE, Rutledge JC. Postprandial VLDL lipolysis products increase monocyte adhesion and lipid droplet formation via activation of ERK2 and NFκB. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H109-20.
Aung HH, Tsoukalas A, Rutledge JC, Tagkopoulos I. A systems biology analysis of brain microvascular endothelial cell lipotoxicity. BMC Syst Biol. 2014 Jul 4;8:80.
Ellis CL, Bokulich NA, Kalanetra KM, Mirmiran M, Elumalai J, Haapanen L, Schegg T, Rutledge JC, Raff G, Mills DA, Underwood MA. Probiotic administration in congenital heart disease: a pilot study. J Perinatol. 2013 Sep;33(9):691-7.
Aung HH, Lame MW, Gohil K, An CI, Wilson DW, Rutledge JC. Induction of ATF3 gene network by triglyceride-rich lipoprotein lipolysis products increases vascular apoptosis and inflammation. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2088-96.
Snodgrass RG, Huang S, Choi IW, Rutledge JC, Hwang DH. Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. J Immunol. 2013 Oct 15;191(8):4337-47.