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John Calvert Rutledge, M.D. View profile as PDF

John Calvert Rutledge

Clinical Interests

John C. Rutledge is an expert in atherosclerosis and lipid disorders. He specializes in preventive cardiology, lipid disorders and reversal of atherosclerotic cardiovascular disease.

Research/Academic Interests

Dr. Rutledge's current laboratory research includes biology of the vascular wall.


Professor, Division of Cardiovascular Medicine
Vice Chair of Research, Internal Medicine
Richard A. and Nora Eccles Harrison Endowed Chair for Diabetes Research


Cardiology, Cardiovascular Medicine, Internal Medicine



Cardiovascular Medicine

Center/Program Affiliation:


Lawrence J. Ellison Ambulatory Care Center
Cardiology Clinic
4860 Y St., Suite 0200
Sacramento, CA 95817
Driving Directions
Phone: 800-800--282-3284

Additional Phone:

Physician Referrals: 916-916--734-5678


M.D., Baylor College of Medicine, Houston TX 1976
B.A., University of Texas, Austin TX 1972


Internal Medicine, University of Tennessee, Memphis TN 1976-1977


Internal Medicine, UC Davis Medical Center, Sacramento CA 1979-1981


Cardiovascular Medicine, UC Davis Medical Center, Sacramento CA 1981-1983

Board Certifications:

American Board of Internal Medicine, 1983
American Board of Internal Medicine, Cardiovascular Disease, 1985

Professional Memberships:

American Association for the Advancement of Science
American College of Cardiology, Fellow
American College of Physicians
American Federation of Clinical Research
American Heart Association, Fellow

Select Honors and Awards:

NIH Travel Award: The Intersection of Metabolic and Neurocognitive Function, NIH Workshop, NIH campus, July 17-18, 2015

Greater Bay Area Research Award Reception, Honoring AHA Northern California Research Awardees, 2011

Top Cited Article 2008-2010, Journal of Vascular Pharmacology, Altman R, Motton DD, Kota RS, Rutledge JC: Inhibition of vascular inflammation by DHEAS in human aortic endothelial cells: Roles of PPAR and NF-kB, 2010

Co-Chair, UC Davis School of Medicine Vice-Chairs for Research, 2011

Chair, Research Affairs Committee, UC Davis Center 2005-, 2013

Executive Council, UC Davis Academic Senate, 2005

Dean?s Excellence in Mentoring Award, UC Davis, 2000

Co-Chair, ?Mouse Models of Diabetic Complications Consortium? Study Sect. Review, NIDDK, 2001

Richard A. and Nora Eccles Harrison Endowed Chair in Diabetes Research, 2000

Chair, Graduate Group in Physiology 1998-, 2001

Select Recent Publications:

To view a detailed list of  Dr. Rutledge's publications, please click here.

Eiselein L, Nyunt T, Lamé MW, Ng KF, Wilson DW, Rutledge JC, Aung HH. TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGF-β Receptor Pathway in Human Aortic Endothelial Cells. PLoS One. 2015 Dec 28;10(12):e0145523.

Ng KF, Anderson S, Mayo P, Aung HH, Walton JH, Rutledge JC. Characterizing blood-brain barrier perturbations after exposure to human triglyceride-rich lipoprotein lipolysis products using MRI in a rat model. Magn Reson Med. 2015 Oct 20. [Epub ahead of print]

Walton JH, Ng KF, Anderson SE, Rutledge JC. MRI measurement of blood-brain barrier transport with a rapid acquisition refocused echo (RARE) method. Biochem Biophys Res Commun. 2015 Aug 7;463(4):479-82.

Yahiatène I, Aung HH, Wilson DW, Rutledge JC. Single-molecule quantification of lipotoxic expression of activating transcription factor 3. Phys Chem Chem Phys. 2014 Oct 21;16(39):21595-601.

Altman R, Keenan AH, Newman JW, Rutledge JC. The Postprandial Effects of a Moderately High-Fat Meal on Lipid Profiles and Vascular Inflammation in Alzheimer's Disease Patients: A Pilot Study. J Gen Pract (Los Angel). 2014;2(6). pii: 186.

den Hartigh LJ, Altman R, Norman JE, Rutledge JC. Postprandial VLDL lipolysis products increase monocyte adhesion and lipid droplet formation via activation of ERK2 and NFκB. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H109-20.

Aung HH, Tsoukalas A, Rutledge JC, Tagkopoulos I. A systems biology analysis of brain microvascular endothelial cell lipotoxicity. BMC Syst Biol. 2014 Jul 4;8:80.

Ellis CL, Bokulich NA, Kalanetra KM, Mirmiran M, Elumalai J, Haapanen L, Schegg T, Rutledge JC, Raff G, Mills DA, Underwood MA. Probiotic administration in congenital heart disease: a pilot study. J Perinatol. 2013 Sep;33(9):691-7.

Aung HH, Lame MW, Gohil K, An CI, Wilson DW, Rutledge JC. Induction of ATF3 gene network by triglyceride-rich lipoprotein lipolysis products increases vascular apoptosis and inflammation. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2088-96.

Snodgrass RG, Huang S, Choi IW, Rutledge JC, Hwang DH. Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. J Immunol. 2013 Oct 15;191(8):4337-47.

To see if John Calvert Rutledge is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

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