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UC Davis Health System

Gregory Melcher, M.D. View profile as PDF

Philosophy of Care

I believe that one of the most important aspects of providing care is establishing a trusting relationship with my patients. I believe in educating them about the disease process so that together we can develop a treatment plan that makes sense and achieves their goals for improving their health.

Clinical Interests

I have broad interests in the breadth of adult infectious diseases, with expertise in the management of HIV infection, systemic fungal infections, endocarditis, osteomyelitis and prosthetic joint infections. My research interests are in the area of conducting clinical trials of new antimicrobial agents for bacterial and fungal infections, and for HIV infection.


Principal Investigator and Medical Director, UC Davis AIDS Education and Training Center
Professor of Clinical Medicine


Infectious Diseases, Internal Medicine


Internal Medicine


Infectious Diseases

Center/Program Affiliation:


Lawrence J. Ellison Ambulatory Care Center
Infectious Diseases Clinic
4860 Y St., Suite 0101
Sacramento, CA 95817
Driving Directions
Phone: 916-734-2737

CARES Clinic
1500 21st St.
Sacramento, CA 95811
Driving Directions
Phone: 800-2-UCDAVIS

Additional Phone:

Clinic Phone: 916-734-2737
Physician Referrals: 800-4-UCDAVIS (800-482-3284)


M.D., University of Minnesota Medical School, Minneapolis, Minnesota, 1982
B.A., University of Minnesota, Minneapolis, Minnesota, 1977


Wilford Hall USAF Medical Center, Lackland AFB, Texas, 1982-83


Wilford Hall USAF Medical Center, Lackland AFB, Texas, 1983-85


Wilford Hall USAF Medical Center, Lackland AFB, Texas, 1985-87

Board Certifications:

American Board of Internal Medicine, 1985
American Board of Internal Medicine, Infectious Disease, 1988

Professional Memberships:

Fellow, American College of Physicians
Fellow, Infectious Diseases Society of America

Select Honors and Awards:

Jay Sanford Award – Armed Forces Infectious Diseases Society of America, 2003

Gold-Headed Cane Award for excellence in patient care, teaching and research, Wilford Hall Medical Center, Lackland AFB, TX, 1994

Archie B. Hoffman Governor's Award for Outstanding Academic Internist in the USAF, 1992

Outstanding Resident Teacher Award, Wilford Hall Medical Center, Lackland AFB, Texas, 1985

Most Valuable Intern Award, Wilford Hall Medical Center, Lackland AFB, Texas, 1983

Alpha Omega Alpha, University of Minnesota, 1982

Phi Beta Kappa, University of Minnesota, 1977

Phi Kappa Phi, National Honor Society, University of Minnesota, 1977

Select Recent Publications:

Asmuth DM. Nguyen HH, Melcher GP, Cohen SH, Pollard RB. Treatments for Hepatitis B. Clin Infect Dis 2004; 39:1353-62.

Oldfield III EC, Fessel WJ, Dunne MW, Dickinson G, Wallace MR, Byrne W, Chung R, Wagner KF, Paparello SF, Craig DB, Melcher G, Zajdowicz M, Williams RF, Kelly W, Zelasky M, Heifets LB, Berman JD. Once weekly azithromycin therapy for the prevention of Mycobacterium avium complex infection in patients with AIDS: a randomized, double-blind, placebo-controlled multicenter trial. Clin Infect Dis 1998; 26:611-619.

Evans JS, Nims T, Cooley J, Bradley W, Jagodzinski L, Zhou S, Melcher GP, Burke DS, Vahey M. Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women. J Infect Dis 1997;175:795-800.

Lucey DR, Pinto L, Bethke DR, Rusnak J, Melcher GP, Landay A, Kessler H, Hashemi F, Grabstein K, Paxton R, Shearer G. In vitro immunologic and virologic effects of interleukin 15 on peripheral blood mononuclear cells from normal donors and human immunodeficiency virus type 1-infected patients. Clin Diag Lab Immunol 1997; 4:43-48.

Melcher GP, Leigh DR. Infections in the Immunocompromised Host. In: Kirby RR, Civetta JM and Taylor RW, eds, Critical Care, 3rd Edition. Philadelphia, J.B. Lippencott Company; 1996.

Chougnet C, Wynn TA, Clerici M, Landay AL, Kessler HA, Rusnak J, Melcher GP, Sher A, Shearer GM. Molecular analysis of decreased interleukin-12 production in individuals infected with the human immunodeficiency virus. J Infect Dis 1996; 174:46-53.

Donta ST, Peduzzi P, Cross AS, Sadoff J, Haakenson C, Cryz SJ Jr, Kauffman C, Bradley S, Gafford G, Elliston D, Beam TR Jr, John JF Jr, Ribner B, Cantey R, Welsh CH, Ellison RT 3rd, Young EJ, Hamill RJ, Leaf H, Schein RMH, Mulligan M, Johnson C, Abrutyn E, Griffis JM, Slagle D, et al. Immunoprophylaxis against Klebsiella and Pseudomonas aeruginosa infections. The Federal Hyperimmune Immunoglobulin Trial Study Group. J Infect Dis 1996; 174:537-543.

Ender PT, Dolan MJ, Dolan D, Farmer JC, Melcher, GP. Near-Drowning-Associated Aeromonas pneumonia. J Emerg Med 1996; 14:737-741.

Melcher, GP, McGough, DA, Fothergill AW, Norris C, and Rinaldi MG. Disseminated hyalohyphomycosis caused by a novel human pathogen, Fusarium napiforme. J Clin Micro 1993; 31:1461-1467.

Walsh TJ, Melcher GP, Lee JW, Pizzo PA. Infections due to Trichosporon species: New Concepts in Mycology, Pathogenesis, Diagnosis, and Treatment. Curr Top Med Mycol 1993; 5:79-113.

Blatt SP, Parkinson MD, Pace E, Hoffman P, Dolan D, Lauderdale P, Zajac RA, Melcher GP. Nosocomial Legionellosis: a One-year Case-Control and Environmental Investigation. In: Barabee JM, Breiman RF, and Durour AP, eds, Legionella - Current Status and Emerging Perspectives, Washington DC, American Society for Microbiology; 1993, 47-50.

Melcher GP, Winn RE. Infections in the Immunocompromised Host. In: Kirby RR, Civetta JM and Taylor RW, eds, Critical Care, 2nd Edition. Philadelphia, J.B. Lippencott Company; 1992, 996-1003.

Zajac RA, Melcher GP: Pulmonary Tuberculosis. In: Williams D, ed, Contemporary Management in Internal Medicine, Vol 2, No. 1, Granulomatous Infections. New York, Churchill Livingstone; 1991, 105-145.

Melcher GP, Winn RE. Infections in the Immunocompromised Host. In: Kirby RR, Civetta JM and Taylor RW, eds, Critical Care. Philadelphia, J.B. Lippencott Company; 1988, 785-795.

To see if Gregory Melcher is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).