Dr. Makker is professor of Pediatric Nephrology. He has board certification from the American Board of Pediatrics in Pediatric Nephrology and has authored the textbook Pediatric Nephrology. He is a fellow of the American Society of Nephrology and a member of a number of professional and scientific societies, including: the American Academy of Pediatrics, the American Pediatric Society, the Society for Pediatric Research, the American Society of Nephrology, the International Society of Nephrology, the American Society of Pediatric Nephrology, the American Society for Investigative Pathology, the American Association of Immunologists, and the Society for Experimental Biology and Medicine. He also is listed among American Men and Women of Science, Outstanding Scientists of the 21st Century, America's Top Pediatricians, America's Top Physicians and Who's Who in America.
Dr. Makker is an eminent expert in the diagnosis and treatment of glomerulonephritides and nephrotic syndrome, and has vast experience in the management of various other kidney disorders in children, including congenital and inherited diseases, hypertension, metabolic disorders, and end-stage kidney failure requiring dialysis or kidney transplantation.
Since the late 1970s, the National Institutes of Health continually has funded his investigations of the pathobiology and molecular biology of glomerular diseases, research for which he is internationally known. He is a member of the reviewing panels of the National Institutes of Health and many scientific journals, including the Journal of Clinical Investigation, the Journal of the American Society of Nephrology, Kidney International, Nature Clinical Practice, the American Journal of Kidney Diseases, Pediatric Nephrology, Hypertension, the Journal of Pediatrics, and the American Journal of Pathology, Clinical Immunology and Immunopathology. He has been involved with the American Society of Nephrology Key Contact Network, the American Society of Pediatric Nephrology Committee on National Standards for Dialysis and Transplantation in Children, and the National Kidney Foundation of the Northern California Medical Advisory Board.
Pediatric Specialty Clinics
2521 Stockton Blvd., Suite 3200
Sacramento, CA 95817
F.Sc., Punjab University, Punjab, India, 1959
Queens General Hospital, New York City, New York, 1966-1967
University of Chicago Hospitals, Chicago, Illinois, 1967-1969
University of California, San Francisco, San Francisco, California, 1971
American Board of Pediatrics, Pediatric Nephrology, 1974
American Association for the Advancement of Science
American Pediatric Society
American Society for Investigative Pathology
American Society of Nephrology
American Society of Pediatric Nephrology
International Pediatric Nephrology Association
International Society of Nephrology
National Kidney Foundation
The American Association of Immunologists
The Society for Experimental Biology and Medicine
The Society for Pediatric Research
Select Recent Publications:
Makker SP, Tramontano A. Idiopathic membranous nephropathy: an autoimmune disease. Semin Nephrol. 2011 Jul;31(4):333-40.
Van Dijk A, Vermond RA, Krijnen PA, Juffermans LJ, Hahn NE, Makker SP, Aarden LA, Hack E, Spreeuwenberg M, van Rossum BC, Meischl C, Paulus WJ, Van Milligen FJ, Niessen HW. Intravenous clusterin administration reduces myocardial infarct size in rats. Eur J Clin Invest. 2010 Oct;40(10):893-902. doi: 10.1111/j.1365-2362.2010.02345.x.
Shcheglova T, Makker S, Tramontano A. Reactive immunization suppresses advanced glycation and mitigates diabetic nephropathy. JAm Soc Nephrol. 20:1012-1019. 2009
Reshetnyak A, Armentano F, Ponomarenko N, Vizzuso D, Durova 0, Ziganshin R, Serebyryakova M, Govorun V, Gololobov G, Morse H, Friboulet A, Makker SP, Gabibov A and Tramontano A. Routes to Covalent Catalysis by Reactive Selection for Nascent Protein Nucleophiles. Journal of the American Chemical Society. 129: 16175-82. 2007.
Shah P, Tramontano A and Makker SP. Intramolecular epitope spreading in Heymann Nephritis. JAm Soc Nephrol. 18:3060-3066. 2007.
Zhao Jun, Tramontano A and Makker SP. Albumin-stimulated TGFB-1 in renal tubular cells is associated with activation of MAP kinase. Int Urol Nephrol 39:1265-1271. 2007.
Tramontano A, Knight T, Vizzuso D, Makker SP. Nested N-terminal megalin fragments induce high-titer autoantibody and attenuated Heymann nephritis. J Am Soc Nephrol, 17:1979-85, 2006.
Makker SP. A prospective comparison of prednisone plus cyclosporin and prednisone alone in pediatric nephrotic syndrome. Nat Clin Pract Nephrol, 2(10):550-551, 2006.
Bavoso A, Ostuni A, De Vendel J, Pollaro F, Armentano F, Knight T, Makker S, Tramontano A. Aldehyde modification of peptide immunogen enhances protein-reactive antibody response to toxic shock syndrome toxin-1. J Pept Sci. 2006 Dec;12(12):843-9.
Makker SP, Tramontano A. Differential capacity of anti-RAP and anti-megalin antibodies to produce progressive passive Heymann nephritis: Implications for the pathogenesis of idiopathic human membranous glomerulonephritis. J Pathol, 210(3):282-287, 2006.
Tramontano A, Makker SP. Conformation and glycosylation of a megalin fragment correlate with nephritogenicity in Heymann nephritis. J Immunol, 172:2367-73, 2004.
Makker SP. Treatment of membranous nephropathy in children. Semin Nephrol. 2003 Jul;23(4):379-85.