Larry Hjelmeland, Ph.D.
Dr. Hjelmeland's research is focused on the origins of age as a risk factor for the development of Age-related Macular Degeneration(AMD). Our current hypothesis is that the genome of the retinal pigment epithelium (RPE) undergoes a defined set of epigenetic modifications which promote the disease.
Ph.D., Stanford University, Stanford, California, 1976
B.S., Stanford University, Stanford, California, 1971
Association for Research in Vision and Ophthalmology
Honors and Awards
Research to Prevent Blindness Senior Scientific Investigators Award, 1995
Inventor's Award presented by NIH in recognition of contribution to economic development through invention of "A Nondenaturing Zwitterionic Detergent for Membrane Biochemistry", 1986
Selected as NIH Nominee for Maryland's Outstanding Young Scientist, 1983
Select Recent Publications
Smit-McBride Z, Oltjen SL, LaVaii MM, Hjelmeland LM: A strong genetic determinant of hyperoxia-related retinal degeneration on mouse chromosome 6, Invest Ophthalmol Vis Sci. 2007 Jan;48( 1):405-11. 2007
P. Alizadeh, Z. Smit-McBride, S. Oltjen, L. Hjelmeland. Regulation of cysteine cathepsin expression by oxidative stress in the retinal pigment epithelium/choroid of the mouse. Experimental Eye Research, Volume 83, Issue 3, Pages 679-687. 2006
Ogawa, H., Boylan, S.A., Oltjen, S.L., Hjelmeland, L.M. Changes in the spatial expression of genes with aging in the mouse RPE/choroid. Mol Vis. 2005 Jun 1;11:380-6.
Tian J, Ishibashi K, Honda S, Boylan S.A., Hjelmeland L.M., Handa J.T. The expression of native and cultured human retinal pigment epithelial cells grown in different culture conditions. Br J Ophthalmol. 2005 Nov;89(11):151 0-7.
Burke J.M., Hjelmeland L.M. Mosaicism of the retinal pigment epithelium: seeing the small picture. Mol Interv. 2005 Aug;5(4):241-9
Ida H, Boylan SA, Weigel AL, Smit-McBride Z, Chao A, Gao J, Buchoff P, Wistow G, Hjelmeland LM. EST analysis of mouse retina and RPE/choroid cDNA libraries. Mol Vis. 2004 Jul 06;10:439-44.
Ida, H., Ishibashi, K., Reiser, K., Hjelmeland, L.M., Handa, J.T. Ultrastructural aging of the RPE-Bruch's membrane-choriocapillaris complex in the D-galactose-treated mouse. Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2348-54.
Miyamura, N., Ogawa, T., Boylan, S.A, Morse, L.S., Handa J.T., Hjelmeland, L.M. Topographic and age-dependent expression of heme oxygenase-1 and catalase in the human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2004 May;45(5): 1562-5.
Ida, H., Boylan, S.A, Weigel, AL., Hjelmeland L.M. Age-related Changes in the Transcriptional Profile of Mouse RPE/choroids. Physiol Genomics Vol 15: 258-262. 2003
Weigel, AL., Ida, H., Boylan, S.A, Hjelmeland, L.M. Acute Hyperoxia Induced Transcriptional Response In The Mouse RPE/Choroid. Free Radic Bioi & Med, Vol. 35, 5:465-474. 2003