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UC Davis Health System

JoAnne E. Natale, M.D., Ph.D. View profile as PDF

JoAnne E. Natale

Clinical Interests

Dr. Natale has clinical interests in pediatric critical care medicine. Her research interests focus on quality improvement, neurocritical care and clinical trials in critically ill children.


Associate Professor
Medical Director, UC Davis Children's Hospital Pediatric Intensive Care Unit


Pediatric Critical Care




Pediatric Critical Care

Center/Program Affiliation:


UC Davis Children's Hospital
2315 Stockton Blvd.
Sacramento, CA 95617
Driving Directions
Phone: 800-282-3284

Additional Phone:

Physician Referrals: 800-4-UCDAVIS (800-482-3284)


M.D., Michigan State University, East Lansing, Michigan, 1993
Ph.D., University of Michigan Medical School, Ann Arbor, Michigan, 1988
B.S., Allentown College, Center Valley, Pennsylvania, 1984


Albert Einstein/Montefiore Medical Center, Bronx, New York, 1994


Albert Einstein/Montefiore Medical Center, Bronx, New York, 1996


Johns Hopkins Hospital, Baltimore, Maryland, 1999

Board Certifications:

American Board of Pediatrics, 1996
American Board of Pediatrics, Critical Care Medicine, 2000

Professional Memberships:

American Academy of Pediatrics, Fellow
National Neurotrauma Society
Neurocritical Care Society
Society for Neuroscience
Society for Pediatric Research, Elected member
Society of Critical Care Medicine
Western Society for Pediatric Research

Select Honors and Awards:

Ambassador of Diversity, UC Davis Health System, 2008

Award for Scientific and Academic Achievement, Clinical Research by Junior Faculty, Children’s Research Institute, Children’s National Medical Center, 2005

Select Recent Publications:

Natale JE, Joseph JG, Honomichl RD, Bazanni LG, Kagawa KJ, Marcin JP. Benchmarking, public reporting, and pay-for-performance: A mixed-methods survey of California pediatric intensive care unit medical directors. Pediatr Crit Care Med. 2011 Nov;12(6):e225-32.

Plymale J, Park J, Natale J, Moon-Grady A. Corrected QT Interval in Children With Brain Death. Pediatr Cardiol. 2010 Oct;31(7):1064-9. Epub 2010 Aug 20.

Natale JE, Hamburger E, Aman M, Asmerom W,Faisal A, Gebremichael F, Haile S, Maekele M, Mohammed M,Tesfaye D, Ghiorghis B, Joseph JG. Intervention to Reduce Parental Bypass of Community Pediatric Primary Health Facilities in Asmara, Eritrea. Journal of Primary Care Community Health 2010 Oct; 1(3): 213-217.

Potter EG, Cheng Y, Natale JE. Deleterious effects of minocycline after in vivo target deprivation of thalamocortical neurons in the immature, metallothionein-deficient mouse brain. J Neurosci Res. 2009 May 1;87(6):1356-68.

Freishtat RJ, Natale J, Benton AS, Cohen J, Sharron M, Wiles AA, Ngor WM, Mojgani B, Bradbury M, Degnan A, Sachdeva R, Debiase LM, Ghimbovschi S, Chow M, Bunag C, Kristosturyan E, Hoffman EP. Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity. Am J Respir Crit Care Med. 2009 Mar 15;179(6):467-73. Epub 2009 Jan 8.

Salorio CF, Slomine BS, Guerguerian AM, Christensen JR, White JR, Natale JE,Shaffner DH, Grados MA, Vasa RA, Gerring JP. Intensive care unit variables and outcome after pediatric traumatic brain injury: a retrospective study of survivors. Pediatr Crit Care Med. 2008 Jan;9(1):47-53.

Potter E*, Cheng Y, Knight JB, Gordish H, Natale JE. Metallothionein I and II expression slows the microglial response to in vivo target deprivation. J Neurotrauma, 24(1):28-42, 2007. (*mentored student)

Natale JE*, Guerguerian A-M*, Joseph JG, McCarter R, Shao C, Slomine B, Christensen J, Johnston J, Shaffner DH. (*equal contributors). Randomized trial of magnesium sulfate infusion in children with severe traumatic brain injury: Feasibility and hemodynamic safety. Pediatric Critical Care Medicine, 8(1):1-9, 2007. (feature article)

Molon A, DiGiovanni S, Hathout Y, Natale J, Hoffman E. Functional recovery of glycine receptors in a spastic murine model of startle disease. Neurobiology of Disease, 21:291-304, 2006.

Natale JE, Joseph JG, Pretzlaff R, Silber T, Guerguerian AM. Clinical trials in pediatric traumatic brain injury: Unique challenges and potential responses. Developmental Neurosci, 28:276-290, 2006.

To see if JoAnne E. Natale is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).