Ruben Fragoso, M.D., Ph.D.

Philosophy of Care

Undergoing radiation treatments can be scary and overwhelming. Each patient has a unique situation involving their specific diagnosis and the treatment of their disease. It is important to recognize the patient's unique issues in order to provide care for the patient as a whole person. It is also important to help patients understand their diagnosis so that they can make more informed decisions and understand their care.

Title:

Assistant Professor

Specialty:

Radiation Oncology, Cancer

Center/Program Affiliation:

UC Davis Comprehensive Cancer Center

Address:

UC Davis Comprehensive Cancer Center
4501 X St., Suite 0140
Sacramento, CA 95817

Phone:

(916) 734-1969

Other Languages:

Spanish

Education:

Harvard Medical School
Boston, Massachusetts
M.D. 2004

Harvard Medical School
Boston, Massachusetts
Ph.D. 2004

Princeton University
Princeton, New Jersey
B.A. 1992

Internships:

Morristown Memorial Hospital
Morristown, New Jersey
2005

Residency:

Thomas Jefferson University Hospital
Philadelphia, Pennsylvania
2009
Radiation Oncology

Professional Memberships:

American Association of Cancer Research
American College of Radiation Oncology
American Society of Therapeutic Radiology and Oncology
Radiological Society of North America

Honors and Awards:

National Dean's List, 1988-93
E.R. Squibb and Sons Senior Thesis Prize, 1988-92

Select Recent Publications:

Donaldson JM, Kari C, Fragoso RC, Rodeck U, Williams JC. Design and development of masked therapeutic antibodies to limit off-target effects: Application to anti-EGFR antibodies. Cancer Biol Ther, 8(22). 2009

Fragoso RC, Pyarajan S, Irie HY, Burakoff SJ. A CD8/Lck transgene is able to drive thymocyte differentiation. J Immunol, 177(9): 6007-17. 2006

Fragoso R, Ren D, Zhang X, Su MW, Burakoff SJ, Jin YJ. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J Immunol, 170(2):913-21. 2003

Halamay KE, Kirkman RL, Sun L, Yamada A, Fragoso RC, Shimizu K, Mitchell RN, McKay DB. CD8 T cells are sufficient to mediate allorecognition and allograft rejection. Cell Immunol, 216(1-2): 6-14. 2002

Sen J, Kapeller R, Fragoso R, Sen R, Zon LI, Burakoff SJ. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. J Immunol, 156(12): 4535-8. 1996

Chauhan D, Kharbanda S, Uchiyama H, Urashima M, Fragoso R, Sen J, Kufe DW, Anderson KC. Identification of upstream signals regulating interleukin-6 gene expression during in vitro treatment of human B cells with pokeweed mitogen. Blood, 84(7): 2243-52. 1994