Jian-Jian Li, M.D., Ph.D.

Clinical/Research Interests

Research interests include the study of the molecular mechanisms causing tumor resistance to radiation and chemotherapy. A tumor resistant signaling network regulated by the transcription factor NF?B and a group of proteins that translocate to the mitochondrion are being investigated in an array of human cancers including breast, lung, prostate and liver. Additional projects are related to radiation-induced adaptive response in normal tissues and in the radiation-resistant cancer stem cells. The goal of these studies is to find therapeutic targets to enhance cancer cure rates by radiotherapy.

Title:

Professor, Director of Translational Research

Specialty:

Radiation Oncology, Cancer

Center/Program Affiliation:

UC Davis Comprehensive Cancer Center

Address:

Oak Park Research Center Building
2700 Stockton Blvd., Suite 1136
Sacramento, CA 95817

Phone:

(916) 703-5174

Other Languages:

Chinese

Education:

The Fourth Military Medical University
Xi'an,
M.D. 1984

University of Iowa
Iowa City, Iowa
Ph.D. 1994

Xi'an Medical College
Xi'an,
B.S. 1979

Residency:

Xi'an Railway Central Hospital
Xi'an,
1981
Radiation Medicine

Fellowships:

National Institutes of Health
Frederick, Maryland
1998
Postdoctoral Fellow: Molecular Carcinogenesis

University of California San Francisco
San Francisco, California
1990
Radiation Oncology

Professional Memberships:

American Association for Cancer Research (AACR)
American Radiation Research Society (RRS)
Association of Free Radical Biology and Medicine (SFRBM)
Association of International Union against Cancer Fellows (UICC)

Honors and Awards:

Seed for Success Award of Purdue University Provost Office, 2004
NIH Cancer Research Fellow Award (NIH-CRFA), National Cancer Institute, National Institutes of Health, 1998
NIH Fellows Award for Research Excellence (NIH-FARE), National Cancer Institute, National Institutes of Health, 1996
NIH Intramural Research Training Award (NIH-IRTA), National Cancer Institute, National Institutes of Health, 1995
Recipient of E. Roosevelt International Cancer Research Award by International Union Against Cancer, 1988

Select Recent Publications:

Nantajit D, Fan M, Duru N, Wen Y, Reed JC, Li JJ. Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PLoS One. 2010 Aug 23;5(8):e12341.

Ahmed KM, Nantajit D, Fan M, Murley JS, Grdina DJ, Li JJ. Coactivation of ATM/ERK/NF-kappaB in the low-dose radiationinduced radioadaptive response in human skin keratinocytes. Free Radic Biol Med, 2009; 46(11): 1543-50.

Wang, Z., Cao, N., Nantajit, D., Fan, M., Liu, Y., and Li, J. J. MKP-1 represses JNK-mediated apoptosis via NF-B regulation. J. Biol. Chem., 2008; 283:21011-21023.

Ahmed KM, Fan M, Nantajit D, Cao N, Li JJ. Cyclin D1 in low-dose radiation-induced adaptive resistance. Oncogene, 2008; 27(53): 6738-48.

Fan, M., Ahmed, K. M., Coleman, M. C., Spitz, D. R., and Li, J. J. NF?B and MnSOD mediate adaptive radioresistance in low dose irradiated mouse skin epithelial cells, Cancer Research, 2007; 67:3220-8.

Wang, T., Tamea, D., LeBon, T., Shively, J., Yan, Y., and Li, J. J. The role of peroxiredoxim II in radiation resistant MCF-7 breast cancer cells. Cancer Research, 2005;65:10338-10346.

Wang, T., Hu, Y.-C., Dong, S. Z., Fan, M., Tamae, D., Ozeki, M., Gao, Q., Gius, D., and Li, J. J. Co-activation of ERK, NF-B and GADD45 in response to ionizing radiation. J. Biol. Chem., 2005;280:12593-12601.

Guo, G., Wang, T., Gao, Q., Tamae, D., Wong, P., Chen, T., Chen, W. C., Shively, J. E., Wong, J. Y. C., and Li, J. J. Activation of NFB in ErbB2 mediated radioresistance. Oncogene, 2004;23:535-545.

Xia, L., Paik, A., and Li, J. J. Activation of p53 in radiation-adapted breast cancer cells: Regulation of p14ARF/MDM2. Cancer Research, 2004; 64:221-228.

Guo, G. Z., Yan-Sanders, Y., Lyn-Cook, B. D., Wang, T., Tamae, D., Ogi, J., Khaletskiy, A., Li, Z. K., Weydert, C., Longmate, J. A., Huang, T.-T., Spitz, D. R., Oberley, L. W., and Li, J. J. Manganese superoxide dismutase mediated gene expression in radiation-induced adaptive responses. Mol. Cell. Biol., 2003;23:2362-2378.