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Department of Radiation Oncology

Jian-Jian Li, M.D., Ph.D. View profile as PDF

Jian-Jian  Li

Clinical Interests

Research interests include the study of the molecular mechanisms causing tumor resistance to radiation and chemotherapy. A tumor resistant signaling network regulated by the transcription factor NF?B and a group of proteins that translocate to the mitochondrion are being investigated in an array of human cancers including breast, lung, prostate and liver. Additional projects are related to radiation-induced adaptive response in normal tissues and in the radiation-resistant cancer stem cells. The goal of these studies is to find therapeutic targets to enhance cancer cure rates by radiotherapy.

Title:

Director of Translational Research
Professor

Department:

Radiation Oncology

Division:

Radiation Oncology

Clinic:

UC Davis Cancer Center

Center/Program Affiliation:

Address/Phone:

Oak Park Research Center Building
2700 Stockton Blvd., Suite 1136
Sacramento, CA 95817
Driving Directions

Other Languages:

Chinese (Mandarin)

Education:

M.D., The Fourth Military Medical University, Xi'an, 1984
Ph.D., University of Iowa, Iowa City, Iowa, 1994
B.S., Xi'an Medical College, Xi'an, 1979

Residency:

Xi'an Railway Central Hospital, Xi'an, 1981

Fellowships:

National Institutes of Health, Frederick, Maryland, 1998
University of California San Francisco, San Francisco, California, 1990

Professional Memberships:

American Association for Cancer Research (AACR)
American Radiation Research Society (RRS)
Association of Free Radical Biology and Medicine (SFRBM)
Association of International Union against Cancer Fellows (UICC)

Select Honors and Awards:

Seed for Success Award of Purdue University Provost Office, 2004

NIH Cancer Research Fellow Award (NIH-CRFA), National Cancer Institute, National Institutes of Health, 1998

NIH Fellows Award for Research Excellence (NIH-FARE), National Cancer Institute, National Institutes of Health, 1996

NIH Intramural Research Training Award (NIH-IRTA), National Cancer Institute, National Institutes of Health, 1995

Recipient of E. Roosevelt International Cancer Research Award by International Union Against Cancer, 1988

Select Recent Publications:

Nantajit D, Fan M, Duru N, Wen Y, Reed JC, Li JJ. Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PLoS One. 2010 Aug 23;5(8):e12341.

Ahmed KM, Nantajit D, Fan M, Murley JS, Grdina DJ, Li JJ. Coactivation of ATM/ERK/NF-kappaB in the low-dose radiationinduced radioadaptive response in human skin keratinocytes. Free Radic Biol Med, 2009; 46(11): 1543-50.

Ahmed KM, Fan M, Nantajit D, Cao N, Li JJ. Cyclin D1 in low-dose radiation-induced adaptive resistance. Oncogene, 2008; 27(53): 6738-48.

Wang, Z., Cao, N., Nantajit, D., Fan, M., Liu, Y., and Li, J. J. MKP-1 represses JNK-mediated apoptosis via NF-B regulation. J. Biol. Chem., 2008; 283:21011-21023.

Fan, M., Ahmed, K. M., Coleman, M. C., Spitz, D. R., and Li, J. J. NF?B and MnSOD mediate adaptive radioresistance in low dose irradiated mouse skin epithelial cells, Cancer Research, 2007; 67:3220-8.

Wang, T., Hu, Y.-C., Dong, S. Z., Fan, M., Tamae, D., Ozeki, M., Gao, Q., Gius, D., and Li, J. J. Co-activation of ERK, NF-B and GADD45 in response to ionizing radiation. J. Biol. Chem., 2005;280:12593-12601.

Wang, T., Tamea, D., LeBon, T., Shively, J., Yan, Y., and Li, J. J. The role of peroxiredoxim II in radiation resistant MCF-7 breast cancer cells. Cancer Research, 2005;65:10338-10346.

Xia, L., Paik, A., and Li, J. J. Activation of p53 in radiation-adapted breast cancer cells: Regulation of p14ARF/MDM2. Cancer Research, 2004; 64:221-228.

Guo, G., Wang, T., Gao, Q., Tamae, D., Wong, P., Chen, T., Chen, W. C., Shively, J. E., Wong, J. Y. C., and Li, J. J. Activation of NFB in ErbB2 mediated radioresistance. Oncogene, 2004;23:535-545.

Guo, G. Z., Yan-Sanders, Y., Lyn-Cook, B. D., Wang, T., Tamae, D., Ogi, J., Khaletskiy, A., Li, Z. K., Weydert, C., Longmate, J. A., Huang, T.-T., Spitz, D. R., Oberley, L. W., and Li, J. J. Manganese superoxide dismutase mediated gene expression in radiation-induced adaptive responses. Mol. Cell. Biol., 2003;23:2362-2378.