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Department of Radiation Oncology

Jian-Jian Li, M.D., Ph.D. View profile as PDF

Jian-Jian  Li

Clinical Interests

Research interests include the study of the molecular mechanisms causing tumor resistance to radiation and chemotherapy. A tumor resistant signaling network regulated by the transcription factor NF?B and a group of proteins that translocate to the mitochondrion are being investigated in an array of human cancers including breast, lung, prostate and liver. Additional projects are related to radiation-induced adaptive response in normal tissues and in the radiation-resistant cancer stem cells. The goal of these studies is to find therapeutic targets to enhance cancer cure rates by radiotherapy.

Title:

Director of Translational Research
Professor

Department:

Radiation Oncology

Division:

Radiation Oncology

Clinic:

UC Davis Cancer Center

Center/Program Affiliation:

Address/Phone:

Oak Park Research Center Building
2700 Stockton Blvd., Suite 1136
Sacramento, CA 95817
Driving Directions

Other Languages:

Chinese (Mandarin)

Education:

M.D., The Fourth Military Medical University, Xi'an, 1984
Ph.D., University of Iowa, Iowa City, Iowa, 1994
B.S., Xi'an Medical College, Xi'an, 1979

Residency:

Xi'an Railway Central Hospital, Xi'an, 1981

Fellowships:

National Institutes of Health, Frederick, Maryland, 1998
University of California San Francisco, San Francisco, California, 1990

Professional Memberships:

American Association for Cancer Research (AACR)
American Radiation Research Society (RRS)
Association of Free Radical Biology and Medicine (SFRBM)
Association of International Union against Cancer Fellows (UICC)

Select Honors and Awards:

Seed for Success Award of Purdue University Provost Office, 2004

NIH Cancer Research Fellow Award (NIH-CRFA), National Cancer Institute, National Institutes of Health, 1998

NIH Fellows Award for Research Excellence (NIH-FARE), National Cancer Institute, National Institutes of Health, 1996

NIH Intramural Research Training Award (NIH-IRTA), National Cancer Institute, National Institutes of Health, 1995

Recipient of E. Roosevelt International Cancer Research Award by International Union Against Cancer, 1988

Select Recent Publications:

Candas, D., Lu, C.L., Fan, M., Chuang, F.Y.S., Sweeney, C., Borowsky, A. D., and Li, J. J. Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. Cancer Research,  revised, June, 2014

Wang, Y., Li, W., Patel, S.S., Cong, J., Zhang, N., Sabbatino, F., Liu, X., Qi, Y., Huang, P., Lee, H., Taghian, A., Li, J.J., DeLeo, A.B., Ferrone, S., Epperly, M.W., Ferrone, C.R., Ly, A., Brachtel, E.F., and Wang, X. Blocking the formation of radiation–induced breast cancer stem cells. Oncotarget, advanced publication, May, 2014

Zou, J.X., Duan, Z., Wang, J., Sokolov, A., Xu, J., Chen, C.Z., Li, J.J., and Chen, H.W., Kinesin family overexpression coordinated by bromodomain protein ANCCA and histone methylase MLL for breast cancer cell growth, survival and tamoxifen resistance. Molecular Cancer Research, DOI: 10.1158/1541-7786, 1, 2014.

Geng, S.Q, Alexandrou, A. T., and Li, J. J. Breast Cancer Stem Cells: Multiple Capacities in Tumor Metastasis. Cancer Letters, 349: 1-7, 2014.

Alexandrou, A. T., and Li, J. J. Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response.  Antioxidants & Redox Signaling, 20, 1463–1480, 2014.

Duru, N., Candas, D., Jiang, G., and Li, J.J.  Breast cancer adaptive resistance:HER2 and cancer stem cell repopulation in a heterogeneous tumor society.   J. Cancer Res. Clin.  Oncol. 140: 1-14, 2014.

Gao, D., Li, C., Xie, X., Zhao, P., Wei, X., Sun, W., Liu, H.C., Jones, J., Zhao, R., and Li, J. J. Autologous tumor lysate-pulsed dendritic cell immunotherapy combined with cytokine-induced killer cells improves survival in gastric and colorectal cancer patients. PLoS ONE, 9 (4) e93886; doi:10.1371; 2014.

Candas, D., and Li, J. J., MnSOD in Oxidative Stress Response-Potential Regulation via Mitochondrial Protein Influx. Antioxidants & Redox Signaling, 20, 1599-1617, 2014.

Ding, N. H., Li, J. J., and Sun, L.Q.  Molecular mechanisms and treatment of radiation-induced lung fibrosis. Current Drug Targets, 14, 1-10, 2013.

Wang, Z., Fan, M., Candas, D., Zhang, T., Qin, L.L., Eldridge, A., Wachsmann-Hogiu, S., Ahmed, K. M., Chromy, B.A., Nantajit, D., Duru, D., He, F., Chen, M., Finkel, T., Weinstein, L.S., and Li, J. J. CyclinB1/Cdk1 Coordinates Mitochondrial Respiration for Cell Cycle G2/M Progression.  Dev. Cell,  29, 217-232, 2014. Highlighted in Nature Cell Biology (16:511, 2014); Science Signaling (7, ec120, 2014)