Michael H. Buonocore, M.D., Ph.D.

Clinical/Research Interests

As a Radioloqical Physicist, Dr. Buonocore develops new magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for challenging problems in clinical medicine and basic imaging science. He focuses on developing MRI pulse sequences and post-processing algorithms for non-invasive measurement of biological processes in the living human. Current projects are (1) measurement and visualization of blood flow in the heart and major vessels, (2) identification of brain disease through measurement of regional NAA, choline, creatine, and lactate (3) measurement of brain water content, (4) measurement of tissue perfusion in brain and body tumors using dynamic contrast enhancement, and (5) measurement of single-kidney GFR for rapid assessment of renal disease. While these projects contribute to the technical capabilities of MRI, they typically also support specific clinical research projects of clinical faculty in Radiology or other departments on the UC Davis Health System campus.

Title:

Professor, Technical Director, UC Davis Imaging Research Center

Specialty:

Radiology Physics, Radiology, Cancer

Center/Program Affiliation:

UC Davis Comprehensive Cancer Center

Education:

Stanford University School of Medicine
Palo Alto, California
M.D. 1983

Stanford University
Stanford, California
Ph.D. 1982

Syracuse University
Syracuse, New York
B.S. 1977

Professional Memberships:

International Society for Magnetic Resonance in Medicine (ISMRM)
Radiological Society of North America (RSNA)

Select Recent Publications:

Salo R, Nordahl TE, Buonocore MH, Natsuaki Y, Waters C, Moore CD, Galloway GP, Leamon MH. Cognitive control and white matter callosal microstructure in methamphetamine-dependent subjects: a diffusion tensor imaging study. Biol Psychiatry. 2009 Jan 15; 65(2): 122-8. Epub 2008 Sep 23. PubMed PMID: 18814867; PubMed Central PMCID: PMC2633131.

Katzberg RW, Buonocore MH, Low R, Hu B, Jain K, Castillo M, Troxel S, Nguyen MM. MR determination of glomerular filtration rate in subjects with solitary kidneys in comparison to clinical standards of renal function: feasibility and preliminary report. Contrast Media Mol Imaging. 2009 Mar; 4(2):51-65. Review. PubMed PMID: 19274681.

Wootton-Gorges SL, Buonocore MH, Caltagirone RA, Kuppermann N, Glaser NS. Progressive Decrease in N-Acetylaspartate/Creatine Ratio in a Teenager with Type 1 Diabetes and Repeated Episodes of Ketoacidosis without Clinically Apparent Cerebral Edema: Evidence for Permanent Brain Injury. AJNR Am J Neuroradiol. 2009 Nov 19. [Epub ahead of print] PubMed PMID: 19926705.

Maddock RJ, Buonocore MH, Copeland LE, Richards AL. Elevated brain lactate responses to neural activation in panic disorder: a dynamic 1H-MRS study. Mol Psychiatry. 2009 May; 14(5):537-45. Epub 2008 Jan 8. PubMed PMID: 18180759.

Glaser NS, Marcin JP, Wootton-Gorges SL, Buonocore MH, Rewers A, Strain J, DiCarlo J, Neely EK, Barnes P, Kuppermann N. Correlation of clinical and biochemical findings with diabetic ketoacidosis-related cerebral edema in children using magnetic resonance diffusion-weighted imaging. J Pediatr. 2008 Oct; 153(4):541-6. Epub 2008 Jun 27. PubMed PMID: 18589447.

Salo R, Nordahl TE, Natsuaki Y, Leamon MH, Galloway GP, Waters C, Moore CD, Buonocore MH. Attentional control and brain metabolite levels in methamphetamine abusers. Biol Psychiatry. 2007 Jun 1; 61(11):1272-80. Epub2006 Nov9. PubMed PMID: 17097074.

Wootton-Gorges SL, Buonocore MH, Kuppermann N, Marcin JP, Barnes PO, Neely EK, DiCarlo J, McCarthy T, Glaser NS. Cerebral proton magnetic resonance spectroscopy in children with diabetic ketoacidosis. AJNR Am J Neuroradiol. 2007 May; 28(5):895-9. PubMed PMID: 17494665.

Shamy JL, Buonocore MH, Makaron LM, Amaral DG, Barnes CA, Rapp PR. Hippocampal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta). Neurobiol Aging. 2006 Oct; 27(1 0): 1405-15. Epub 2005 Sep 23. PubMed PMID: 16183171.

Harrington GS, Buonocore MH, Farias ST. Intrasubject reproducibility of functional MR imaging activation in language tasks. AJNR Am J Neuroradiol, 2006 Apr; 27(4):938-44. PubMed PMID: 16611797.

Glaser NS, Wootton-Gorges SL, Buonocore MH, Marcin JP, Rewers A, Strain J, DiCarlo J, Neely EK, Barnes P, Kuppermann N. Frequency of sub-clinical cerebral edema in children with diabetic ketoacidosis. Pediatr Diabetes. 2006 Apr; 7(2):75-80. PubMed PMID: 16629712.