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Department of Orthopaedic Surgery

Dominik R. Haudenschild, Ph.D. View profile as PDF

Clinical Interests

Dr. Haudenschild's research focus is in the interactions between the chondrocyte cytoskeleton and signal transduction events which lead to the regulation of gene expression and extracellular matrix synthesis required for the maintenance of health cartilage and the interactions between COMP and ADAMTS enzymes that create osteoarthritis biomarkers.


Assistant Professor


Orthopaedic Surgery


Orthopaedic Surgery


Orthopaedic Research


Research I
4635 2nd Ave., Suite 3004
Sacramento, CA 95817
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Ph.D., UC Davis, Davis, California, 2003
B.A., Boston University, Boston, Massachusetts, 1989

Professional Memberships:

American Association for Cancer Research, Associate Member
International Cartilage Repair Society
Orthopaedic Research Society, Active Member
OsteoArthritis Research Society International, Active Member

Select Recent Publications:

Haudenschild DR, Chen J, Pang N, Lotz MK, D'Livia DD; Rho-Kinose-Dependent Activation of SOX9 in Chondrocytes; Arthritis and Rheumatism, 62(1). 2010

Haudenschild DR, Chen J, Steklov N, Lotz MK, D'Lima DD. Characterization of the Chondrocyte Actin Cytoskeleton in Living Three-Dimensional Culture: Response to Anabolic and Catabolic Stimuli. Molecular Cellular Biomechanics, 6(3): 135-144. 2009

Haudenschild DR, D'Lima DD, Lotz MK., Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton. Biorheology. 2008;45(3-4):219-28.

Haudenschild DR, Nguyen B, Chen J, D'Lima DD, Lotz MK., Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes. Arthritis Rheum. 2008 Sep;58(9):2735-42.

T.Kokubu, D.R. Haudenschild, T.A. Moseley, L. Rose, and A.H. Reddi, Immunolocalization of IL-17A, IL-17B, and their Receptors in Chondrocytes During Fracture Healing, Journal of Histochemistry and Cytochemistry 2007; Feb;56(2):89-95.

D.R. Haudenschild, D.D. D’lima, and M.K. Lotz, Dynamic Compression of Chondrocytes Induces a Rho Kinase-Dependent Reorganization of the Actin Cytoskeleton, Biorheology 2007; Special Issue 5th International Symposium of Mechanobiology of Cartilage and Chondrocyte.

D.R. Haudenschild, S. Curtiss, T.A. Moseley, and A. Hari Reddi, Generation of Interleukin-17 Receptor-Like Protein (IL-17RL) in Prostate by Alternative Splicing of RNA, The Prostate 2006; 66(12), pp.1268-1274.

Z. You, X.B. Shi, G. DuRaine, D.R. Haudenschild, C.G. Tepper, S.H. Lo, R Gandour-Edwards, R.W. deVere-White, and A. Hari Reddi, Interleukin-17 Receptor-Like Gene is a Novel Antiapoptotic Gene Highly Expressed in Androgen-Independent Prostate Cancer, Cancer Research 2006; 66:(1), pp. 175-183.

D.R. Haudenschild, S.M. Palmer, T.A. Moseley, Z. You, and A. Hari Reddi, Bone Morphogenetic Protein 6 (BMP-6) Signaling and BMP-antagonist Noggin in Prostate Cancer, Cancer Research 2004 November 15; 64: 8276–8284.

T.A. Moseley & D.R. Haudenschild, and A.H. Reddi, Interleukin-17 Family and IL-17 Receptors, Cytokine & Growth Factor Reviews 2003; 14: 155–174, Dominik Haudenschild, pg 4.

D.R. Haudenschild, T. Moseley, L. Rose and A.H. Reddi, Soluble and Transmembrane Isoforms of Novel Interleukin-17 Receptor-Like Protein by RNA Splicing and Expression in prostate cancer, Journal of Biological Chemistry 2002; Feb 8;277(6):4309–16

D.R. Haudenschild, R. Tubo, J.M. McPherson, and F. Binette, Differential Gene Expression the During Early Events of Chondrocyte Differentiation, Anatomical Record 2001; 263(1): 91–98.