SpecialtiesCharles L. Stebbins, M.D. 
Clinical/Research Interests
In general, my research interest is control of the circulation as it relates to regulation of blood pressure and blood flow during exercise. One research focus I have concerns afferent aspects of cardiovascular reflexes from skeletal muscle. This involves determination of various metabolic stimuli that are capable of eliciting or modulating cardiovascular responses.
I am also interested in the contribution of specific hormones/neuropeptides e.g. vasopressin, oxytocin, angiotensin II, and endothelin to peripheral, spinal, and central modulation of the cardiovascular response to exercise in normal and pathophysiological conditions i.e., heart failure and hypertension.
A recent research focus is vascular biology as it relates to endothelial function during exercise. We are studying human vascular endothelial cells to determine if supplementation with omega-3 polyunsaturated fatty acids enhances activation and/or expression of important proteins associated with nitric oxide production.
Studies of healthy individuals and heart failure patients are also being conducted to determine if these omega-3 fatty acids are capable of enhancing skeletal muscle blood flow and lessening systemic vascular resistance during dynamic exercise.
Title:
Specialty:
Center/Program Affiliation:
Education:
Madison, Wisconsin
M.D. 1981
UC Berkeley
Berkeley, California
M.A. 1974
Fellowships:
San Diego, CA
1985
Cardiology
Professional Memberships:
American Heart Association, Council on High Blood Pressure Research
American Physiological Society
Society for Neuroscience
Select Recent Publications:
Kim, H.B., Stebbins, C.L., Chai, J.H., and Song, J.K. Taekwondo training and fitness in female adolescents. Journal of Sports Sciences 2011 29: 133-138.
Stebbins, C.L., Hammel, L.E., Marshal, B.J., Spangenberg, E.E., and Musch T.I. Effects of dietary omega-3 polyunsaturated fatty acids PUFAs on the skeletal muscle blood flow response to exercise in rats. International Journal of Sports Nutrition and Metabolism 2010 20: 475-486.
Stebbins, C.L., J.P. Stice, C.M. Hart, F.N. Mbai, and A.A. Knowlton. Effects of dietary decosahexaenoic acid DHA on eNOS in human coronary artery endothelial cells. Journal of Cardiovascular Pharmacology and Therapeutics 2008 13: 261-268.
Walser, M., and C.L. Stebbins. Omega-3 fatty acid supplementation enhances stroke volume and cardiac output during dynamic exercise. European Journal of Applied Physiology 2008 97: 347-354.
Moore, J.L., J.D. Shaffrath, G.A. Casazza, and C.L Stebbins. Cardiovascular effects of cadence and workload. International Journal of Sports Medicine 29: 116-119, 2008.
