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Department of Internal Medicine

Mark A. Zern, M.D. View profile as PDF

Clinical Interests

Mark Zern earned his undergraduate and medical degrees at Harvard University. He joined UC Davis as Professor of Medicine, Director, Transplant Research Institute, and as the first recipient of the Fred and Pat Anderson Family Endowed Chair in Transplant Research. A researcher and active clinical hepatologist for 30 years, Zern is the editor of two books and the author of more than 120 publications. He has received continuous funding from NIH since 1979. He is a nationally and internationally recognized authority in the areas of liver fibrosis, liver gene therapy and liver stem cell biology. He has been the Chair of Gastroenterology and Hepatology at two institutions, chaired an NIH study section, the Grants Review Committee of the American Liver Foundation, and the Liver Task Force of the Alpha-1 Foundation. He is presently the President of the International Study Group for Stem Cell Therapy.




Gastroenterology and Hepatology, Internal Medicine


Internal Medicine


Gastroenterology and Hepatology


UC Davis Medical Center
2315 Stockton Blvd.
Sacramento, CA 95817
Driving Directions
Phone: 800-2-UCDAVIS (800-282-3284)

Additional Phone:

Physician Referrals: 800-4-UCDAVIS (800-482-3284)


M.D., Harvard Medical School, Boston, Massachusetts, 1975
A.B., Harvard University, Cambridge, Massachusetts, 1969


Cambridge Hospital, Cambridge, Massachusetts, 1975-1976


Cambridge Hospital, Cambridge, Massachusetts, 1976-1977
Mary Hitchcock Hospital, Dartmouth College, Hanover, New Hampshire, 1977-1978


Albert Einstein College of Medicine, Bronx, New York, 1979-1982
Tufts-New England Medical Center, Boston, Massachusetts, 1978-1979

Board Certifications:

American Board of Internal Medicine, 1978

Professional Memberships:

American Association for the Advancement of Science
American Association for the Study of Liver Diseases (AASLD)
American Society of Clinical Investigation
International Association for the Study of the Liver

Select Recent Publications:

Jones CN, Tuleuova N, Lee JY, Ramanculov E, Reddi AH, Zern MA, Revzin A. Hepatocyte growth factor microarrays induce and maintain differentiated phenotype in primary rat hepatocytes. Biomaterials 30:3733-3741; 2009.

Kim T-H, Venugopal SK, Zhu M, Wang S-S, Lau D, Lam Ks, Clemens DL, Zern MA. A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells. Biochem. Biophys. Res. Comm. 379:876-881; 2009.

Lee JY, Tuleuova N, Jones CN, Ramanculov E, Zern MA, Revzin A. Directing hepatic differentiation of embryonic stem cells with protein microarray-bassed co-cultures. Integrative Biology 1:437-488; 2009.

Tatsukawa H, Fukaya Y, Frampton G, Martinez-Fuentes A, Suzuki K, Kuo TF, Nagstsuma K, Shimokado K, Okuno M, Wu J, lismaa S, Matsuura T, Tsukamoto H, Zern MA, Graham RM, Kojima S. Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology 136:1783-1795; 2009.

Zern, MA. Cell transplantation to replace whole liver transplantation. Gastroenterology 136:767-769; 2009.

Ma X, Duan Y, Jung CJ, Wu J, VandeVoort CA, Zern MA. The differentiation of hepatocyte-like cells from monkey embryonic stem cells. Cloning and Stem Cells 10:485-493; 2008.

Jones CN, Lee JY, Stybayeva GS, Zern MA, Revzin A. Multifunctional protein microarrays for cultivation of cells and immunodetection of secreted cellular products. Anal. Chem 80:6351-6357; 2008.

Choi MS, Catana AM, Wu J, Kim YS, Borowski AD, Gambhir SS, Gupta S, Zern MA. Use of bioluminescent imaging to assay the transplantation of immortalized human fetal hepatocytes into mice. Cell Transplantation 17:899-910; 2008.

Duan Y, Catana A, Meng Y, Songqing H, Gupta S, Gambhir S, Zern, MA. Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo using lentivirus vector systems. Stem Cells 25:3058-3068; 2007.

Kim J-W, Zhang Y, Zern MA, Rossi JJ, Wu J. Short hairpin RNA causes the methylation of transforming growth factor-ureceptor II promoter and silencing of the target gene in rat hepatic stellate cells. Biochem. Biophys. Res. Comm. 359:292-297; 2007.

Seo S, Ramsamooj R, McVicar J, Bowlus C, Tsodikov A, Khehra M, Zern M, Torok N. De novo nonalcoholic fatty liver disease after liver transplantation. Liver Transplantation 13:844-847; 2007.

Venugopal SK, Chen J, Zhang YH, Follenzi A, Clemens D, Wu J, Zern MA. Role of MAP kinase phosphatase-1 in sustained activation of c-Jun N-terminal Kinase (JNK) during ethanol-induced apoptosis in hepatocytes. J BioI. Chem. 282:31900-31908; 2007.

Venugopal SK, Wu J, Catana A, Eisenbud L, He S, Duan Y, Follenzi A, Zern MA. Lentivirus-mediated superoxide dismutase1 gene delivery protects against oxidative stress-induced liver injury in mice. Liver International 27:1311-1322; 2007.

Zhang Y*, Venugopal SK*, He S, Liu P, Wu J, Zern MA. Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms. Cell Signaling 19:2339-2350; 2007.

To see if Mark A. Zern is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).