Sidika Karakas, M.D.

Sidika E. Karakas, M.D.


Endocrinology, Diabetes, and Metabolism

Internal Medicine


Internal Medicine


  • Professor and Chief
To see if Sidika E. Karakas is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

Lawrence J. Ellison Ambulatory Care Center

4860 Y St., Suite 0400
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Clinic Phone: 916-734-2737
Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Philosophy of Care

When treating PCOS patients, there are several important points to consider: First, early and correct diagnosis is crucial. Ordering the appropriate tests requires experience and expertise. Second, PCOS is a life-long condition and the patient's goals change with time. Thus, the doctor's treatment plan needs to change to fit these goals. Third, PCOS treatment is a team work, including not only the patient and the doctor but also the dietitian and the pharmacist. Finally, this journey takes compassion, patience and persistence.

I truly enjoy taking care of PCOS patients. In the past, these women did not receive medical attention until they desired pregnancy. Fortunately, this has changed. We now start taking care of women with PCOS in their early teens. I feel privileged to help these young, otherwise healthy women in my clinical practice and with my research.

Clinical Interests

Dr. Karakas’s clinical practice is dedicated to the care of women with polycystic ovary syndrome (PCOS). This is a complex disease characterized by endocrine and metabolic disorders. The endocrine aspects of PCOS involve irregular periods, infertility, and excess hair in the face and body. Metabolic aspects include obesity, insulin resistance, and predisposition to diabetes and lipid disorders. It is important to recognize that endocrine and metabolic aspects of PCOS interact with each other. For example, weight loss and treatment of insulin resistance regulate menstrual periods and increase fertility.

Dr. Karakas’s research focuses on the effects of diet and nutritional supplements on obesity, insulin resistance, lipid disorders, inflammation and reproductive abnormalities associated with PCOS. She is especially interested in the effects of different proteins and fatty acids. She has conducted numerous nutrition intervention studies and clinical translational research funded by the National Institutes of Health and non-profit research foundations.


Endocrinology, Diabetes, and Metabolism


M.D., Hacettepe University, Ankara, 1973


Cook County Hospital, Chicago, Illinois, 1977


Rush Presbyterian St. Luke’s, Chicago, Illinois, 1999

Board Certifications

American Board of Internal Medicine, 1977

American Board of Internal Medicine, Endocrinology, 1979

Professional Memberships

Androgen Excess Society

Endocrine Society

Select Recent Publications

Gurusinghe D, Gill S, Almario RU, Lee J, Horn WF, Keirn NL, Kim K, Karakas SE. In PCOS, adrenal steroids are regulated differently in the morning vs. in response to nutrient intake. Fertility and Sterility, Epub ahead of print, March 2009. PMID: 19342030

Karakas SE., Almario R, Kim K. Serum fatty acid binding protein 4, free fatty acids and metabolic risk markers. Metabolism Clinical and Experimental 58: 1002-1007, 2009. PMID: 19394980

Kasim-Karakas SE, Almario RU, Cunningham WM. Effects of protein vs. simple sugar intakes on weight loss in polycystic ovary syndrome (according to the NIH criteria). Fertility and Sterility 92:262-270, 2009. PMID: 18691705

Kasim-Karakas SE, Cunningham WM, Tsodikov A. Relation of nutrients and hormones in polycystic ovary syndrome. Am J Clin Nutr 85:688-694, 2007. PMID: 16600927

Kasim-Karakas SE, Tsodikov A, Singh U, Jialal I. Responses of Inflammatory Markers to Low-Fat/High-Carbohydrate Diet: Effects of Energy Intake. Am J Clin Nutr 83:774-779, 2006. PMID: 16600924

Chen J, Sowers MR, Moran FM, McConnell DS, Gee NA, Greendale GA, Whitehead C, Kasim-Karakas SE, Lasley BL. Circulating bioactive androgens in midlife women. J Clin Endocrinol Metab 91:4387-94, 2006. PMlD: 16940455

Kasim-Karakas SE, Almario RU, Gregory L, Wong R, Todd H, Lasley BL. Metabolic and Endocrine Effects of a Polyunsaturated Fatty Acid-Rich Diet in Polycystic Ovary Syndrome. J Clin Endocrinol Metab 89:615-20, 2004. PMID: 14764771

Mueller-Cunningham WM, Quintana R, Kasim-Karakas, S.E. An ad-libitum very low-fat diet results in weight loss and changes in nutrient intakes in post-menopausal women. J Am Dietetic Assoc 103:1600-6, 2003. PMID: 14647085

Almario RU, Vonghavaravat V, Wong R, Kasim-Karakas SE. Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. Am J Clin Nutr 74:72-79, 2001. PMID: 11451720

Kasim-Karakas SE, Almario RU, Mueller WM, Peerson J. Changes in plasma lipoproteins during low-fat, high carbohydrate diets: Effects of energy intake. Am J Clin Nutr 71:1439-1447, 2000. PMID: 10837283