Philosophy of Care
When treating PCOS patients, there are several important points to consider: First, early and correct diagnosis is crucial. Ordering the appropriate tests requires experience and expertise. Second, PCOS is a life-long condition and the patient's goals change with time. Thus, the doctor's treatment plan needs to change to fit these goals. Third, PCOS treatment is a team work, including not only the patient and the doctor but also the dietitian and the pharmacist. Finally, this journey takes compassion, patience and persistence.
I truly enjoy taking care of PCOS patients. In the past, these women did not receive medical attention until they desired pregnancy. Fortunately, this has changed. We now start taking care of women with PCOS in their early teens. I feel privileged to help these young, otherwise healthy women in my clinical practice and with my research.
Dr. Karakas’s clinical practice is dedicated to the care of women with polycystic ovary syndrome (PCOS). This is a complex disease characterized by endocrine and metabolic disorders. The endocrine aspects of PCOS involve irregular periods, infertility, and excess hair in the face and body. Metabolic aspects include obesity, insulin resistance, and predisposition to diabetes and lipid disorders. It is important to recognize that endocrine and metabolic aspects of PCOS interact with each other. For example, weight loss and treatment of insulin resistance regulate menstrual periods and increase fertility.
Dr. Karakas’s research focuses on the effects of diet and nutritional supplements on obesity, insulin resistance, lipid disorders, inflammation and reproductive abnormalities associated with PCOS. She is especially interested in the effects of different proteins and fatty acids. She has conducted numerous nutrition intervention studies and clinical translational research funded by the National Institutes of Health and non-profit research foundations.
Endocrinology, Diabetes & Metabolism Clinic
4860 Y St., Suite 0400
Sacramento, CA 95817
Physician Referrals: 800-4-UCDAVIS (800-482-3284)
American Board of Internal Medicine, Endocrinology, 1979
Select Recent Publications:
Gurusinghe D, Gill S, Almario RU, Lee J, Horn WF, Keirn NL, Kim K, Karakas SE. In PCOS, adrenal steroids are regulated differently in the morning vs. in response to nutrient intake. Fertility and Sterility, Epub ahead of print, March 2009. PMID: 19342030
Karakas SE., Almario R, Kim K. Serum fatty acid binding protein 4, free fatty acids and metabolic risk markers. Metabolism Clinical and Experimental 58: 1002-1007, 2009. PMID: 19394980
Kasim-Karakas SE, Almario RU, Cunningham WM. Effects of protein vs. simple sugar intakes on weight loss in polycystic ovary syndrome (according to the NIH criteria). Fertility and Sterility 92:262-270, 2009. PMID: 18691705
Kasim-Karakas SE, Cunningham WM, Tsodikov A. Relation of nutrients and hormones in polycystic ovary syndrome. Am J Clin Nutr 85:688-694, 2007. PMID: 16600927
Kasim-Karakas SE, Tsodikov A, Singh U, Jialal I. Responses of Inflammatory Markers to Low-Fat/High-Carbohydrate Diet: Effects of Energy Intake. Am J Clin Nutr 83:774-779, 2006. PMID: 16600924
Chen J, Sowers MR, Moran FM, McConnell DS, Gee NA, Greendale GA, Whitehead C, Kasim-Karakas SE, Lasley BL. Circulating bioactive androgens in midlife women. J Clin Endocrinol Metab 91:4387-94, 2006. PMlD: 16940455
Kasim-Karakas SE, Almario RU, Gregory L, Wong R, Todd H, Lasley BL. Metabolic and Endocrine Effects of a Polyunsaturated Fatty Acid-Rich Diet in Polycystic Ovary Syndrome. J Clin Endocrinol Metab 89:615-20, 2004. PMID: 14764771
Mueller-Cunningham WM, Quintana R, Kasim-Karakas, S.E. An ad-libitum very low-fat diet results in weight loss and changes in nutrient intakes in post-menopausal women. J Am Dietetic Assoc 103:1600-6, 2003. PMID: 14647085
Almario RU, Vonghavaravat V, Wong R, Kasim-Karakas SE. Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. Am J Clin Nutr 74:72-79, 2001. PMID: 11451720
Kasim-Karakas SE, Almario RU, Mueller WM, Peerson J. Changes in plasma lipoproteins during low-fat, high carbohydrate diets: Effects of energy intake. Am J Clin Nutr 71:1439-1447, 2000. PMID: 10837283