Our laboratory studies the interface between the skeletal and immune systems, a newly emerging area of research called “osteoimmunology”. Haematopoietic stem cells in the bone marrow give rise to both T cells which are important in inflammation and osteoclasts that regulate bone resorption. Differentiation and activation of osteoclasts from their precursors is tightly regulated by cytokines and growth factors such as receptor activator of nuclear factor kappa beta (RANKL), tumor necrosis factor (TNF) and various interleukins. Receptor engagement of these molecules results in signaling cascades and transcriptional changes that give rise to medical conditions such as rheumatoid arthritis, osteoporosis and osteopetrosis. Using in vivo gene transfer of immune cytokines IL-23 and IL-17, we have established new arthritis animal models that highlight the importance of these immune cytokines in arthritis initiation and bone homeostasis. Using in vitro assays, we continue our attempts to define the cellular and molecular mechanisms that take place in this fascinating interplay of the immune and skeletal systems.
University of Oxford
University of Surrey
Honors and Awards:
Sontag Fellow, 2011
Wolfson College, Oxford D. Phil Scholarship, 2003
Select Recent Publications:
IE Adamopoulos, S Pflanz. The emerging role of Interleukin 27 in inflammatory arthritis and bone destruction. Cytokine Growth Factor Rev. Epub 2012 Nov 16.
TJ Dickerson, E Suzuki, C Stanecki, HS Shin, H Qui and IE Adamopoulos*. Rheumatoid and pyrophosphate arthritis synovial fibroblasts induce osteoclastogenesis independently of RANKL, TNF and IL-6. Journal of Autoimmunity 2012 Dec;39(4):369-76.*** Paper was highlighted by Nature Reviews Rheumatology: Bone: An alternative pathway for bone destruction in inflammatory arthritis? Ray K. Nat Rev Rheumatol. 2012 Oct;8(10):563.
*IE Adamopoulos, M Tessmer, CC Chao, S Adda, D Gorman, M Petro, CC Chu, RH Pierce, W Yao, NE Lane, D Laface, *EP Bowman. IL-23 is critical for the induction of arthritis, osteoclast formation and maintenance of bone mass. Journal of Immunology 2011 15:187(2):951-9.
*IE Adamopoulos, CC Chao, R Geissler, DM Laface, W Blumenschein, T McClanahan and EP Bowman. IL-17A upregulates RANK on osteoclast precursors. Arthritis Research and Therapy 2010 Feb 18;12(1):R29.
CC Chao, SJ Chen, IE Adamopoulos, EP Bowman. Structural, cellular, and molecular evaluation of bone erosion in experimental arthritis models: assessment by µCT, histology, and serum biomarkers. Autoimmunity 2010 Dec;43(8):642-53.
B Joyce-Shaikh, M Bigler, CC Chao, E Murphy, IE Adamopoulos, P Heyworth, E Bowman, T McClanahan, J Phillips and DJ Cua*. Myeloid DAP12- associating lectin (MDL)-1 receptor regulates synovial inflammation and bone erosion associated with autoimmune arthritis. Journal of Experimental Medicine 2010 Mar 15;207(3):579-89.
SJ Harney, C Vilariño-Güell, IE Adamopoulos, AM Sims, RW Lawrence, LR Cardon, JL Newton, C Meisel, JJ Pointon, C Darke, NA Athanasou, BP Wordsworth, MA Brown. Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis. Rheumatology (Oxford) 2008;47(12):1761-7.
*IE Adamopoulos and EP Bowman. Immune regulation of bone loss by Th17 cells. Arthritis Research and Therapy 2008;10(5):225.
*IE Adamopoulos and K Pataridis. Quantification of bone resorption in experimental model of arthritis by a novel software “Osteo-Pro”. Journal of Computational Methods in Science and Engineering 2007;7(2):87-91.
YS Lau, IE Adamopoulos, H Giele, CLMH Gibbons, NA Athanasou. Cellular and humoral mechanisms of osteoclast formation in Ewing’s Sarcoma. British Journal of Cancer 2007;96(11):1716-22.