Little Rock, Arkansas
National Taiwan University School of Medicine
National Taiwan University
San Diego, California
American Society for Biochemistry and Molecular Biology
American Thoracic Society
Honors and Awards:
Pfizer Award for Research Excellence, Veterinary Medicine, UC Davis, 2006
Faculty Research Award, UC Davis School of Medicine, 1996
National Institutes of Health Merit Award, R37 HL35635, 1995
Member of National Institutes of Health Lung Biology and Pathology Study Section, 1993-1997
Joan Oettinger Memorial Award, UC Davis School of Medicine, 1993
Select Recent Publications:
Chen Y, Hamati E, Lee WM, Wachi S, Schnurr D, Shigeo Y, Dolganov G, Boushey H, and Wu R. Rhinovirus induces airway epithelial gene expression through double-stranded RNA and IFN-dependent pathways. Am J Respir Cell Mol Biol, 34:192-203.
Wachi S, Yoneda K, and Wu R. Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics, 21(23):4205-4208.
Thai P, Chen Y, Dolganov G, and Wu R. Differential regulation of MUC5AC/Muc5ac and hCLCA-1/mGob-5 expression in airway epithelium. American J Respir Cell Mol Biol, 33(6):523-530.
Kao CY, Huang F, Chen Y, Thai P, Wachi S, Kim C, Tam L, and Wu R. Up-regulation of CC chemokine ligand 20 expression in human airway epithelium by IL-17 through a JAK-independent but MEK/NF-kappaB-dependent signaling pathway. J Immunol, 175:6676-6685.
Harper RW, Xu C, Eiserich JP, Kao CY, Thai P, Setiadi H, and Wu R. Differential regulation of dual NADPH oxidase/peroxidase, Duox 1 and Duox 2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Letter, 579:4911-4917.
Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, and Wu R. Interleukin-17 markedly up-regulates b-defensin 2 expression in human airway epithelium via JAK and NF-kB pathways. J Immunol, 173:3482-3491.
Chen Y, Zhao YH, Kalaslavadi TJ, Hamati E, Nehrke K, Le AD, Ann DK, and Wu R. Genome-wide search of novel gel-forming mucin genes and identification of MUC19/Muc19 as a new glandular tissue-specific mucin gene. Am J Respir Cell Mol Biol, 30:155-165.
Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, and Wu R. Stimulation of airway mucin gene expression by IL-17 through IL-6 paracrine/autocrine loop. J Biol Chem, 278:17036-17043.
Kao CY, Chen Y, Zhao YH, and Wu R. ORFeome-based search of airway epithelial cell-specific novel human b-defensin genes. Am J Respir Cell Mol Biol, 29:71-80.
Di YP, Zhao YH, Harper R, and Wu R. Molecular cloning, and characterization of a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts, SPURT. J Biol Chem, 278:1165-1173.