Trained as a biochemist and electrophysiologist, Marie E. Burns studies the temporal regulation of signal transduction mechanisms in neurons. Much of her work has investigated the deactivation of the G protein cascade in photoreceptor cells of the retina. Her future studies will seek to understand the mechanisms by which different G protein cascades yield signals of varying amplitude and durations, such as in the rod and cone photoreceptors in the retina.
Ph.D., Neurobiology and Cell & Molecular Biology, Duke University, Durham NC 1996
M.S., Neurobiology, Duke University, Durham NC 1994
B.S., Susquehanna University, Selinsgrove PA 1992
Neurobilogy, Stanford University, Palo Alto CA 1996-2000
American Society for Cell Biology
Association for Research in Vision and Ophthalmology
Association for the Advancement of Science
Society for Neuroscience
Honors and Awards
Faculty Service Award, Neuroscience Graduate Group, 2015
Outstanding Graduate Mentor in Neuroscience, UC Davis Neuroscience Graduate Students, 2013
Select Recent Publications
Burns ME, Levine ES, Miller EB, Zam A, Zhang P, Zawadzki RJ, Pugh EN Jr. New Developments in Murine Imaging for Assessing Photoreceptor Degeneration In Vivo. Adv Exp Med Biol. 2016;854:269-75.
Zhang P, Zam A, Jian Y, Wang X, Li Y, Lam KS, Burns ME, Sarunic MV, Pugh EN Jr, Zawadzki RJ. In vivo wide-field multispectral scanning laser ophthalmoscopy-optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature. J Biomed Opt. 2015 Dec;20(12):126005.
Zawadzki RJ, Zhang P, Zam A, Miller EB, Goswami M, Wang X, Jonnal RS, Lee SH, Kim DY, Flannery JG, Werner JS, Burns ME, Pugh EN Jr. Adaptive-optics SLO imaging combined with widefield OCT and SLO enables precise 3D localization of fluorescent cells in the mouse retina. Biomed Opt Express. 2015 May 21;6(6):2191-210.
Gross OP, Pugh EN Jr, Burns ME. cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses. Front Mol Neurosci. 2015 Mar 4;8:6.
Fortenbach CR, Kessler C, Peinado Allina G, Burns ME. Speeding rod recovery improves temporal resolution in the retina. Vision Res. 2015 May;110(Pt A):57-67.
Levine ES, Zam A, Zhang P, Pechko A, Wang X, FitzGerald P, Pugh EN Jr, Zawadzki RJ, Burns ME. Rapid light-induced activation of retinal microglia in mice lacking Arrestin-1. Vision Res. 2014 Sep;102:71-9.
Arshavsky VY, Burns ME. Current understanding of signal amplification in phototransduction. Cell Logist. 2014 Jun 4;4:e29390.
Kessler, C., Tillman, M., Burns, M.E., and Pugh, E.N., Jr. Rapid regeneration of rod photoreceptor surface rhodopsin measured with the early receptor potential in vivo. J. Physiol. 2014;592,2785-97.
Zam, A., Zhang, P., Levine, E., Pugh, E.N., Jr., Burns, M.E. and Zawadzki, R.J. Evaluation of OCT for quantitative in-vivo measurements of changes in neural tissue scattering in longitudinal studies of retinal degeneration in mice. Proc. SPIE, 2014;8934, 893422-1-893422-6.
Long JH, Arshavsky VY, Burns ME. Absence of synaptic regulation by phosducin in retinal slices. PLoS One. 2013 Dec 20;8(12):e83970.