Francis R. Poulain, M.D.

Clinical/Research Interests

Dr. Poulain focuses his research on the biology of lung surfactant and its metabolism using a variety of biophysical and molecular techniques. He serves as a senior mentor to other researchers, advising them about laboratory methods, molecular biology techniques, grant writing, and design and implementation of studies.

Title:

Associate Professor, Director of Neonatal-Perinatal Training Program

Specialty:

Pediatric Neonatology

Center/Program Affiliation:

UC Davis Children's Hospital

Address:

UC Davis Medical Center
2315 Stockton Blvd., Suite NICU
Sacramento, CA 95817

Other Languages:

French

Education:

University of Medicine
Caen,
M.D. 1975

Universite Rene Descarte
Paris,
Certificate 1979

Institut Notre-Dame
Avranches, Frances
B.S. 1969

Residency:

University of Utah
Salt Lake City, Utah
1985-1988
Pediatrics

Fellowships:

UC San Francisco
San Francisco, California
1988-1991
Neonatal-Perinatal Medicine

Board Certifications:

American Board of Pediatrics, 1999
American Board of Pediatrics, Neonatal-Perinatal Medicine, 1999

Professional Memberships:

American Academy of Pediatrics
American Academy of Pediatrics, Fellow
American Association for the Advancement of Science
American Thoracic Society
Society for Pediatric Research
Western Society for Pediatric Research

Honors and Awards:

Research Grant (PI, HSRA), 2003-2005
Research Grant R01 (Co-investigator, HD38462), 2000-2001
Program Project Grant (Project co-leader, HL24075), 1999-2004
Research Grant R01 (Co-principal Investigator, HL58047), 1997-2002

Select Recent Publications:

Hortobágyi L, Kierstein S, Krytska K, Zhu X, Das AM, Poulain F, Haczku A. Surfactant protein D inhibits TNF-alpha production by macrophages and dendritic cells in mice. J Allergy Clin Immunol. 2008 Sep;122(3):521-8. Epub 2008 Jun 12.

Chiou HL, Diaz R, Orlino E Jr, Poulain FR. Acute airway obstruction by a sheared endotracheal intubation stylet sheath in a premature infant. J Perinatol. 2007 Nov;27(11):727-9.

Kierstein S, Poulain FR, Cao Y, Grous M, Mathias R, Kierstein G, Beers MF, Salmon M, Panettieri RA Jr, Haczku A. Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D. Respir Res. 2006 Jun 1;7:85.

Haczku A, Cao Y, Vass G, Kierstein S, Nath P, Atochina-Vasserman EN, Scanlon ST, Li L, Griswold DE, Chung KF, Poulain FR, Hawgood S, Beers MF, and Crouch EC. IL-4 and IL-13 Form a Negative Feedback Circuit with Surfactant Protein-D in the Allergic Airway Response. J Immunol. 176(6):3557-3565.

Sorensen GL, Madsen J, Kejling K, Tornoe I, Nielsen O, Townsend P, Poulain F, Nielsen CH, Reid KB, Hawgood S, Falk E, Holmskov U. Surfactant protein D is proatherogenic in mice. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2286-94. Epub 2005 Dec 30.

Hawgood S, Brown C, Edmondson J, Stumbaugh A, Allen L, Goerke J, Clark H, and Poulain F. Pulmonary collectins modulate strain-specific type A influenza infection and host responses. J Virol. Aug, 78(16):8565-72, 2004

Atochina EN, Gow AJ, Beck JM, Haczka A, Inch A, Kadire H, Tomer Y, Davis C, Preston AM, Poulain F, Hawgood S, and Beers MF. Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice. J Infect Dis. 189(8):1528-9, 2004.

Atochina EN, Beers MF, Hawgood S, Poulain F, Davis C, Fusaro T, and Gow AJ. Surfactant Protein-D, a mediator of innate lung immunity, alters the products of NO metabolism. Am J Respir Cell Mol Biol. 30(3):271-9, 2004.

Hawgood S, Ochs M, Jung A, Akiyama J, Allen L, Brown C, Edmondson J, Levitt S, Carlson E, Gillespie AM, Villar A, Epstein CJ, Poulain FR. Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema. Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L1002-10.

Hawgood S, Poulain FR. The pulmonary collectins and surfactant metabolism. Annu Rev Physiol. 2001;63:495-519. Review.

To see if Francis R. Poulain is accepting new patients, or for assistance finding a UC Davis doctor, please call (800) 2-UC DAVIS.