Randi J. Hagerman, M.D., F.A.A.P.

Clinical/Research Interests

Randi J. Hagerman has more than 20 years of experience in the field of neurodevelopmental disorders and fragile X syndrome -- the most common inherited cause of mental retardation. Her research focuses on the correlation between an individual's molecular genotype, or genetic make-up, and physical and behavioral characteristics, in addition to targeted treatments for Fragile X Syndrome and the fragile X-associated tremor ataxia syndrome (FXTAS). She also has a strong clinical and research interest in autism and has conducted research examining the association between autism and fragile X syndrome. Her books include Neurodevelopmental Disorders: Diagnosis and Treatment, published by Oxford University Press in 1999, and Fragile X Syndrome: Diagnosis, Treatment, and Research, published by Johns Hopkins in 2002.

Title:

Medical Director of the MIND Institute, Professor and Endowed Chair in Fragile X Research

Specialty:

Pediatric Child Development & Behavior

Center/Program Affiliation:

UC Davis Children's Hospital, UC Davis MIND Institute

Address:

UC Davis MIND Institute
2825 50th St.
Sacramento, CA 95817

Phone:

(916) 703-0247

Other Languages:

Spanish

Education:

Stanford University School of Medicine
Palo Alto, California
M.D., F.A.A.P. 1975

UC Davis
Davis, California
B.S. 1971

Internships:

Stanford University School of Medicine
Palo Alto, California
1975-76

Residency:

University of California, San Diego
La Jolla, California
1979-80

Stanford University School of Medicine
Palo Alto, California
1976-77

Fellowships:

University of California, San Diego
La Jolla, California
1978-80

Professional Memberships:

American Academy of Pediatrics
American Society of Human Genetics
Society of Developmental and Behavioral Pediatrics

Select Recent Publications:

Hashimoto R, Javan AK, Tassone F, Hagerman RJ, Rivera SM. (2011) A voxel-based morphometry study of grey matter loss in fragile X-associated tremor/ataxia syndrome. Brain Mar 2011:134(Pt. 3):863-78.

Hashimoto RI, Srivastava S, Tassone F, Hagerman RJ, Rivera SM. Diffusion tensor imaging in male premutation carriers of the fragile X mental retardation gene. Mov Disord Apr 2011, doi: 10.1002/mds.23646 [Epub ahead of print] PMID: 21484870.

Narcisa V, Aguilar D, Nguyen DV, Campos L, Brodovsky J, White S, Adams P, Tassone F, Hagerman PJ, Hagerman RJ. A Quantitative Assessment of Tremor and Ataxia in Female FMR1 Premutation Carriers using CATSYS. Current Gerentology and Geriatrics Research doi:10.1155/2011/484713.

Hashimoto R, Javan AK, Tassone F, Hagerman RJ, Rivera SM. A voxel-based morphometry study of grey matter loss in fragile X-associated tremor/ataxia syndrome. BRAIN 2011 134(Pt 3):863-878.

Hashimoto R, Backer KC, Tassone F, Hagerman RJ, Rivera SM. (2011) An fMRI study of the prefrontal activity during the performance of a working memory task in premutation carriers of the fragile X mental retardation 1 gene with and without fragile X-associated tremor/ataxia syndrome (FXTAS). J Psychiatr Res 2011;45(1)36-43.

Greco CM, Navarro CS, Hunsaker MR, Maezawa I, Shuler JF, Tassone F, Delany M, Au JW, Berman RF, Jin LW, Schumann C, Hagerman PJ and Hagerman RJ Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome. Mol Autism 2011 Feb 8;2(1):2. doi:10.1186/2040-2392-2-2 PMC3045897

Zhang L, Sukharev D, Schneider A, Olichney JM, Seritan A, Hagerman RJ. Case report: Dystonia in a fragile X carrier. Mov Disord 2011 (Epub ahead of print].

Stöger R, Genereux DP, Hagerman RJ, Hagerman PJ, Tassone F, Laird CD. Testing the FMR1 Promoter for Mosaicism in DNA Methylation among CpG Sites, Strands, and Cells in FMR1-Expressing Males with Fragile X Syndrome. PLoS ONE:6(8):E23648. EPub 2011 Aug 31.

Ortigas MC, Bourgeois JA, Schneider A, Olichney J, Nguyen DV, Cogswell JB, Hall DA, Hagerman RJ. Improving fragile X-associated tremor/ataxia syndrome symptoms with memantine and venlafaxine. J Clin Psychopharmacol 2010;30(5):642-4.

Schneider A, Ballinger E, Chavez A, Tassone F, Hagerman RJ, Hessl D. Prepulse inhibition in patiens with fragile X-associated tremor/ataxia syndrome. Neurobiol Aging 2010 [Epub ahead of print].

To see if Randi J. Hagerman is accepting new patients, or for assistance finding a UC Davis doctor, please call (800) 2-UC DAVIS.