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UC Davis Children’s Hospital

Ruth J. McDonald, M.D. View profile as PDF

Clinical Interests

Ruth J. McDonald's areas of expertise include asthma, cystic fibrosis, chronic lung disease, and malformations of the lung. Her research focuses on pediatric pulmonary diseases and quality improvment.


Chief of Pediatric Pulmonology
Professor of Clinical Pediatrics


Pediatric Pulmonology




Pediatric Pulmonology

Center/Program Affiliation:


Glassrock Building
Pediatric Specialty Clinics
2521 Stockton Blvd.
Sacramento, CA 95817
Driving Directions
Phone: 800-282-3284

Additional Phone:

Physician Referrals: 800-4-UCDAVIS (800-482-3284)


M.D., Oregon Health & Science University School of Medicine, Portland, Oregon, 1978
B.S., University of Oregon, Eugene, Oregon, 1974


University of Colorado, Denver, Colorado, 1978-79


Oregon Health Sciences University, Portland, Oregon, 1979-82


University of Colorado Health Sciences Center, Denver, Colorado, 1982-85

Board Certifications:

American Board of Pediatrics, 1985
American Board of Pediatrics, Pediatric Pulmonology, 1986

Professional Memberships:

American Academy of Pediatrics
American Thoracic Society

Select Recent Publications:

Maniar-Hew K, Postlethwait EM, Fanucchi MV, Ballinger CA, Evans MJ, Harkema JR, Carey SA, McDonald RJ, Bartolucci AA, Miller LA. Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge. Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L462-71. Epub 2010 Dec 3.

Kott KS, Salt BH, McDonald RJ, Jhawar S, Bric JM, Joad JP. Effect of secondhand cigarette smoke, RSV bronchiolitis and parental asthma on urinary cysteinyl LTE4. Pediatric Pulmonology, 43(8): 760-766. 2008

Hendrickson OJ, Blumberg DA, Joad JP, Jhawar S, McDonald RJ. Five-fold increase in pediatric parapneumonic empyema since introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J, 27(11 ):1030-32. 2008

Tarantal AF, McDonald RJ, Jimenez OF, Lee CC, O'Shea CE, Leapley AC, Won RH, Plopper CG, Lutzko C, Kohn DB. Intrapulmonary and intramyocardial gene transfer in rhesus monkeys (Macaca mulatta): safety and efficiency of HIV-1-derived lentiviral vectors for fetal gene delivery. Molecular Therapy 12(1 ):87-98. 2005

Fanucchi MV, Schelegle ES, Baker GL, Evans MJ, McDonald RJ, Gershwin LJ, Raz E, Hyde OM, Plopper CG, Miller LA. Immunostimulatory Oligonucleotides Attenuate Airways Remodeling in Allergic Monkeys. American Journal of Respiratory and Critical Care Medicine 170: 1153-1157. 2004

McBeth CL, McDonald RJ, Hodge MB. Antibiotic sampling from central venous catheters versus peripheral veins. Journal of Pediatric Nursing 30(3):200-202. 2004

Malone JG, Steen land PR, McDonald RJ, Sanchez RA, Watts TL, Zabner J, Malone RW. DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. Journal of Gene Medicine 4:323-332. 2002

Hardin KA, Kallas HJ, McDonald RJ. Pharmacologic management of the hospitalized pediatric asthma patient. In Clinical Review in Allergy and Immunology. Humana Press 20:293-326, 2001.

Tarantal AF, Lee CI, Ekert JE, McDonald RJ, Kohn DB, Plopper CG, Case SS, Bunnell BA. Lentiviral vector gene transfer into fetal rhesus monkeys (macaca mulatta): Lung-targeting approaches. Molecular Therapy 4(6):614-621, 2001.

Miller LA, Usachenko J, McDonald RJ,Hyde DM: Trafficking of neutrophils across airway epithelium is dependent upon both thioredoxin- and pertussin-sensitive signaling mechanisms. Journal of Leukocyte Biology 68(2):201-208, 2000.

Sterner-Kock A, Braun RK, van der Vliet A, Schrenzel MD, McDonald RJ, Kabbur MB, Vuilliet PR, Hyde DM: Substance p primes the formation of hydrogen peroxide and nitric oxide in human neutrophils. J. Leukocyte Biology 65:834-840, 1999.

McDonald, R. J., Liggitt, H. D., Roche, L., Nguyen, H. T., et. al. Aerosol delivery of lipid: DNA complexes to lungs of rhesus monkeys. Pharmaceutical Research, 15:671-679, 1998

McDonald, R. J., Lukason, M. J., Rabbe, O. G., et. al. Safety of airway gene transfer with Ad2/CFTR2: aerosol administration in the non-human primate. Human Gene Therapy, 8:411-422, 1997

Check, J. M., McDonald, R. J., Rapalyea, L., et. al. Neutrophils enhance removal of ozone-injured alveolar epithelial cells in vitro. American Journal of Physiology, 269:L527-L535, 1995

Joad, J. P., McDonald, R. J., Giri, S. N., Bric, J. M. Ozone effects on mechanics and arachidonic acid metabolite concentrations in isolated rat lungs. Environmental Research, 66:160-172, 1994

McDonald, R. J., Pan, L. C., St. George, et. al. Hydrogen peroxide induces DNA single strand breaks in respiratory epithelial cells. Inflammation, 17(6): 715-722, 1993

To see if Ruth J. McDonald is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).