Effects of Tobacco Smoke on Lung Development, Respiratory and Environmental Toxicology, Pulmonary Toxicology and Epidemiology, Health Impacts of Nanomaterials and Nanotechnology
Health effects of environmental air pollutants on lung structure and function; the interaction of gases and airborne particles within specific sites and cell populations of the lungs in acute and chronic lung injury; the effects of environmental tobacco smoke, gases and particles on lung growth, lung development, immunoregulation and neural control; and health implications of engineered nanomaterials in the workplace, environment and therapeutic applications.
Interim Director John Muir Institute of the Environment
Professor in Residence, Department of Anatomy, Physiology and Cell Biology, School of Medicine
Professor, Department of Pediatrics, School of Medicine
B.S., Brigham Young University, Provo, Utah, 1974
M.S., Duke University, Durham, North Carolina, 1978
American Association of Veterinary Anatomists
American Thoracic Society
Microscopy Society of America
Society of Toxicology
UC Davis Cancer Center
Honors and Awards:
University of California Distinguished Teaching Citation, 2008
Distinguished Faculty Teaching Award, School of Veterinary Medicine, 2006
Favorite Teacher Award, Class of 2003, School of Veterinary Medicine, 2000
Favorite Teacher Award, Class of 2001, School of Veterinary Medicine, 1998
Select Recent Publications:
Case BW, Abraham JL, Meeker G, Pooley FD, Pinkerton KE. Applying definitions of "asbestos" to environmental and "low-dose" exposure levels and health effects, particularly malignant mesothelioma. J Toxicol Environ Health B Crit Rev. 14(1-4):3-39. Review.
Davis BB, Liu JY, Tancredi DJ, Wang L, Simon SI, Hammock BD, Pinkerton KE.The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment. Biochem Biophys Res Commun. 410(3):494-500. Epub 2011 Jun 7.
Filosto S, Castillo S, Danielson A, Franzi L, Khan E, Kenyon N, Last J, Pinkerton K, Tuder R, Goldkorn T. Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury. Am J Respir Cell Mol Biol. 44(3):350-60. Epub 2010 May 6.
Harrison CM, Pompilius M, Pinkerton KE, Ballinger SW. Mitochondrial oxidative stress significantly influences atherogenic risk and cytokine-induced oxidant production. Environ Health Perspect. 119(5):676-81. Epub 2010 Dec 17.
Herr CE, Ghosh R, Dostal M, Skokanova V, Ashwood P, Lipsett M, Joad JP, Pinkerton KE, Yap PS, Frost JD, Sram R, Hertz-Picciottol. Exposure to air pollution in critical prenatal time windows and IgE levels in newborns. Pediatr Allergy Immunol, 22(1 pt 1):75-84.
Sandberg KL, Pinkerton KE, Poole SD, Minton PA, Sundell HW. Fetal nicotine exposure increases airway responsiveness and alters airway wall composition in young lambs. Respir Physiol Neurobiol. 176(1-2):57-67. Epub 2010 Dec 30.
Sekizawa S, Joad JP, Pinkerton KE, Bonham AC. Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure. Br J Pharmacol. 163(4):782-91.
Villablanca AC, Pinkerton KE, Rutledge JC. Maternal and neonatal exposure to environmental tobacco smoke targets pro-inflammatory genes in neonatal arteries. J Cardiovasc Transl Res. 3(6):696-703. Epub 2010 Oct 2.
Wang, L., Green, H.Y., Smiley-Jewell, S.M., and Pinkerton, K.E. Susceptibility of the aging lung to environmental injury. Seminars in Respiratory and Critical Care Medicine 31(5):539-553.
Miyagawa M, Fukuda M, Hirono Y, Kawazoe A, Shigeyoshi E, Sakura M, Takeuchi T, Mazda O, Pinkerton KE and Takeuchi M. Effect of jungle honey on the chemotactic activity of neutrophils. Journal of ApiProduct and ApiMedical Science 2(4):149-154