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UC Davis Comprehensive Cancer Center

Edwin Alexander Alvarez, M.D. View profile as PDF

Edwin Alexander Alvarez

Clinical Interests

Dr. Alvarez’s primary focus is the surgical and medical treatment of ovarian cancer, cervical cancer, endometrial cancer and other malignancies of the female reproductive system.

He holds a strong clinical interest in complicated gynecologic procedures and is adept at laparoscopic minimally invasive surgery. He also provides chemotherapy for patients with gynecologic cancers. 

Research/Academic Interests

Dr. Alvarez is the director of chemotherapy services for gynecologic oncology. His main research interest is in clinical trials for gynecologic cancers, and he leads the development and administration of our clinical trial program. 


Associate Professor


Gynecology Oncology, Cancer, Obstetrics and Gynecology


Gynecologic Oncology

Center/Program Affiliation:


UC Davis Comprehensive Cancer Center
2279 45th Street
Sacramento, CA 95817
Driving Directions
Phone: 916-734-5959
Phone: 800-800--362-5566

Additional Phone:

Physician Referrals: 800-362-5566

Other Languages:



M.D., UC San Diego School of Medicine, San Diego CA 2000
B.A., UC Berkeley, Berkeley CA 1995


University of Southern California, Keck School of Medicine, Los Angeles CA 2001


University of Southern California, Keck School of Medicine, Los Angeles CA 2004


University of Miami, Leonard B. Miller School of Medicine, Miami FL 2007

Board Certifications:

American Board of Obstetrics and Gynecology, 2010
American Board of Obstetrics and Gynecology, Gynecologic Oncology,

Professional Memberships:

Gynecologic Oncology Group
Gynecologic Oncology Group Developmental Therapeutics
Society of Gynecologic Oncology

Select Recent Publications:

Crean KK, Huang EC, Alvarez EA. Synchronous uterine adenocarcinoma and leiomyosarcoma: A rare case report causing a clinical conundrum. Int J Surg Case Rep. 2016;22:32-4. Epub 2016 Mar 11.

Sugahara KN, Scodeller P, Braun GB, de Mendoza TH, Yamazaki CM, Kluger MD, Kitayama J, Alvarez E, Howell SB, Teesalu T, Ruoslahti E, Lowy AM. A tumor-penetrating peptide enhances circulation-independent targeting of peritoneal carcinomatosis. J Control Release. 2015 Aug 28;212:59-69. Epub 2015 Jun 11.

Mayadev J, Li CS, Lim J, Valicenti R, Alvarez EA. Alcohol Abuse Decreases Pelvic Control and Survival in Cervical Cancer: An Opportunity of Lifestyle Intervention for Outcome Improvement. Am J Clin Oncol. 2015 Mar 13. [Epub ahead of print]

Alvarez EA, Brady WE, Walker JL, Rotmensch J, Zhou XC, Kendrick JE, Yamada SD, Schilder JM, Cohn DE, Harrison CR, Moore KN, Aghajanian C. Phase II trial of combination bevacizumab and temsirolimus in the treatment of recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2013 Apr;129(1):22-7.

Shang X, Lin X, Alvarez E, Manorek G, Howell SB. Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases. Neoplasia. 2012 Oct;14(10):974-85.

McCullough MC, Oh EE, Lucci JA 3rd, Alvarez EA. Ureteral-arterial fistula: A case report and review of the literature. Journal of Obstetrics and Gynaecology. 2012 Oct; 32(7): 617-20.

Ward KK, Shah NR, Saenz CC, McHale MT, Alvarez EA, Plaxe SC. Cardiovascular disease is the leading cause of death among endometrial cancer patients. Gynecologic Oncology. 2012 Aug;126(2):176-9.

Chen Y, Alvarez EA, Azzam D, Wander SA, Guggisberg N, Jordà M, Ju Z, Hennessy BT, Slingerland JM. Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo. Breast Cancer Res Treat. 2011 Jul;128 (1):69-78.

Alvarez EA, Wolfson AH, Pearson JM, Crisp M, Mendez LE, Lambrou NC, Lucci JA 3rd. A phase I study of docetaxel as a radiosensitizer for locally advanced squamous cell cervical cancer. Gynecologic Oncology. 2009 May; 113(2):195-9/

To see if Edwin Alexander Alvarez is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).