Ruben Fragoso, M.D., Ph.D.

Philosophy of Care
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Specialty:
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Address:
4501 X St., Suite 0140
Sacramento, CA 95817
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Other Languages:
Education:
Boston, Massachusetts
M.D. 2004
Harvard Medical School
Boston, Massachusetts
Ph.D. 2004
Princeton University
Princeton, New Jersey
B.A. 1992
Internships:
Morristown, New Jersey
2005
Residency:
Philadelphia, Pennsylvania
2009
Radiation Oncology
Professional Memberships:
American College of Radiation Oncology
American Society of Therapeutic Radiology and Oncology
Radiological Society of North America
Honors and Awards:
E.R. Squibb and Sons Senior Thesis Prize, 1988-92
Select Recent Publications:
Donaldson JM, Kari C, Fragoso RC, Rodeck U, Williams JC. Design and development of masked therapeutic antibodies to limit off-target effects: Application to anti-EGFR antibodies. Cancer Biol Ther, 8(22). 2009
Fragoso RC, Pyarajan S, Irie HY, Burakoff SJ. A CD8/Lck transgene is able to drive thymocyte differentiation. J Immunol, 177(9): 6007-17. 2006
Fragoso R, Ren D, Zhang X, Su MW, Burakoff SJ, Jin YJ. Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck, and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling. J Immunol, 170(2):913-21. 2003
Halamay KE, Kirkman RL, Sun L, Yamada A, Fragoso RC, Shimizu K, Mitchell RN, McKay DB. CD8 T cells are sufficient to mediate allorecognition and allograft rejection. Cell Immunol, 216(1-2): 6-14. 2002
Sen J, Kapeller R, Fragoso R, Sen R, Zon LI, Burakoff SJ. Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase. J Immunol, 156(12): 4535-8. 1996
Chauhan D, Kharbanda S, Uchiyama H, Urashima M, Fragoso R, Sen J, Kufe DW, Anderson KC. Identification of upstream signals regulating interleukin-6 gene expression during in vitro treatment of human B cells with pokeweed mitogen. Blood, 84(7): 2243-52. 1994

