Robert T. O'Donnell, M.D., Ph.D. 
Clinical Interests
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Address/Phone:
4501 X St.
Sacramento, CA 95817
Driving Directions
Phone: 800-362-5566
Additional Phone:
Education:
Ph.D., University of Illinois at Chicago, Chicago, Illinois, 1983
B.S., Loyola University, Chicago, Illinois, 1977
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Residency:
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Board Certifications:
American Board of Internal Medicine, 2002
American Board of Internal Medicine, Medical Oncology, 1994
American Board of Internal Medicine, Medical Oncology, 2002
Professional Memberships:
Honors and Awards:
U.S. Patent 6,217,871 "Antigenic Epitopes with Lym-1 Reactivity and Uses Thereof": Larry Rose, PhD, Claude Meares, PhD and Robert o"Donnell MD, PhD, 2001
American Cancer Society Clinical Fellowship, 1990
University of Illinois Graduate College Fellowship, 1983
Select Recent Publications:
Tuscano JM, YP Ma, SM Martin, J Kato, RT O'Donnell. The Bs20x22 Anti-CD20-CD22 Bispecific Antibody has more Lymphomacidal Activity than do the Parent Monoclonal Antibodies Alone.. Cancer Immunol. Immunother., 60: 771-780.
Tuscano JM, Martin SM, Ma Y, Zamboni W, O'Donnell RT. Efficacy, biodistribution, and pharmacokinetics of CD22-targeted pegylated liposomal doxorubicin in a B-cell non-Hodgkin's lymphoma xenograft mouse model. Clin Cancer Res, 16(10): 2760-8.
2009 O'Donnell RT, D Pearson, HC McKnight, YP Ma, JM Tuscano. Phosphatase inhibition augments anti-CD22-mediated signaling and cytotoxicity in non-Hodgkin's lymphoma cells. Leuk Res. Feb 21. [Epub ahead of print]
2009 O'Donnell RT, D Pearson, HC McKnight, YP Ma, JM Tuscano. Treatment of non-Hodgkin's lymphoma xenografts with the HB22.7 anti-CD22 monoclonal antibody and phosphatase inhibitors improves efficacy. Cancer Immunol Immunother. Mar 18. [Epub ahead of print]
2009 O'Donnell RT, SM Martin, YP Ma, WC Zamboni, JM Tuscano. Development and characterization of CD22-targeted pegylated liposomal doxorubicin (IL-PLD). Invest New Drugs. In press.
2009 O'Donnell RT, YP Ma, HC McKnight, D Pearson, JM Tuscano. Dose, timing, schedule, and the choice of targeted epitope alter the efficacy of anti-CD22 immunotherapy in mice bearing human lymphoma xenografts. Cancer Immunol lmmunother. 58(12):2051-2058.
2008 Pearson DP, RT O'Donnell, K Lam, JM Tuscano. CD22-binding peptides derived from anti-CD22 ligand blocking antibodies retain the targeting and cell killing properties of the parent antibodies and may serve as a drug delivery vehicle. International Journal of Peptide Research and Therapeutics, 14:237-246.
2009 Martin SM, RT O'Donnell, DL Kukis, C Abbey, H McKnight, JL Sutcliffe, JM Tuscano. Imaging and pharmacokinetics of 64Cu-DOTA-HB22.7 administered by intravenous, intraperitoneal, or subcutaneous injection to mice bearing non-Hodgkin lymphoma xenografts. Mol Imaging BioI. 11(2):79-87.
2007 Schillaci O, GL DeNardo, SJ DeNardo, DS Goldstein, LA Kroger, RT O'Donnell, KR Lamborn. Effect of anti-lymphoma antibody, 131 I-Lym-1 on peripheral blood lymphocytes in patients with non-Hodgkin's lymphoma. Cancer Biother Radiopharm, 22(4):521-30.
2007 Semrad TJ, RT O'Donnell, T Wun, H Chew, D Harvey, H Zhou, RH White. Epidemiology of venous thromboembolism in 9489 patients with malignant glioma. J Neurosurg 106(4):601-608.
2006 Lehmann J, GL DeNardo, A Yuan, S Shen, RT O'Donnell, CM Richman, SJ DeNardo. Comparison of normal tissue pharmacokinetics with 1111n/90y monoclonal antibody m170 for breast and prostate cancer. Int J Radiat Oncol Biol Phys. 66(4):1192-1198.
2006 O'Donnell RT. Nuclear Localizing Sequences May be a New Way to Increase Efficacy and Decrease the Toxicity of Systemic Targeted Radiotherapy. Invited Perspective. Journal of Nuclear Medicine. 47(5):738-739.
