Ultrasound in ALS Natural History Study
Natural History Studies – Neuromuscular Research Center
Ultrasound in ALS/NMD: (M-mode Ultrasound as a measure of Respiratory Dysfunction in patients with Amyotrophic Lateral Sclerosis and other Neuromuscular diseases (NMD).
The purpose of this study is to learn more about the use of an ultrasound in identifying diaphragm dysfunction and to predict respiratory failure in patients diagnosed with ALS and other neuromuscular diseases. These ultrasound diagnostic results will in turn be compared to the current use of PFTs as a primary indicator of respiratory function.
There are no interventions for this study. We call these studies "Natural History Studies."
- Confirmed diagnosis of ALS
- Confirmed clinical diagnosis supported by EMG (Electromyography) is defined as upper motor neuron or lower motor neuron findings in three of four anatomic regions. These regions include bulbar, cervical, thoracic and lower lumbar
- Clinically probably ALS is defined as upper motor neuron and lower motor neuron findings in two of four anatomic regions, or upper motor neuron findings rostral to the lower motor neuron findings.
- Confirmed diagnosis of Neuromuscular disease by either genetic testing, muscle biopsy or EMG (Electromyography)
- Able to consent to participate in the study
- Cognitively Impaired
- Diagnosis of Obesity, defined as having a BMD greater than 30
- Evidence by EMG or Neuro-imaging supporting the possibility of another disease process