Dr. Bodine is a Neuromuscular Physiologist whose general field of study is Skeletal Muscle Plasticity. Her primary research interests are in understanding the cellular and molecular mechanisms that regulate skeletal muscle size under growth and atrophy conditions. Currently her lab is studying the role of mTOR-mediated pathways in the regulation of muscle growth and adaptive hypertrophy in young and aging animals. In addition, her lab is investigating the physiological function and transcriptional regulation of two muscle specific E3 Ubiquitin Ligases: MuRF1 and MAFbx, in both skeletal and cardiac tissues.
Bodine, S.C., Stitt, T.N., Gonzalez, M., Kline, W.O., Stover, G.L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J.C., Glass, D.J., and, Yancopoulos, G.D. The AKT/mTOR pathway is a critical regulator of skeletal muscle hypertrophy, and can prevent muscle atrophy in vivo. Nature Cell Biology 3: 1014-1019, 2001.
Rommel, C., Bodine, S.C., Clarke, B.A., Rossman, R., Nunez, L., Stitt, T.N., Yancopoulos, G.D., and Glass, D.J. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI3K/AKT/mTOR and PI3K/AKT/GSK3 pathways. Nature Cell Biology 3: 1009-1013, 2001.
Bodine, S.C., Latres, E., Baumhueter, S., Lai, V.K.-L., Nunez, L., Clarke, B., Poueymirou, W., Panaro, F., Na, E., Dharmarajan, K., Pan, Z-Q., Valenzuela, D.M., .DeChiara, T.M., Stitt, T.N., Yancopoulos, G.D., and Glass, D.J. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294:1704-1708, 2001 (published in Scienceexpress/ 25 October 2001/10.1126/science 1065874).
Isfort, R.J., Wang, F., Greis, K.D., Sun, Y., Keogh, T.W., Farrar, R.P., Bodine, S.C., and Anderson, N.L. Proteomic analysis of rat soleus muscle undergoing hindlimb suspension-induced atrophy and reweighting hypertrophy. Proteomics 2: 543-550, 2002.
Reynolds, T.H., Bodine, S.C., and Lawrence, J.C. Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin, amino acids, and skeletal muscle loading. J. Biol. Chem. 277: 17657-17662, 2002.
Bodine, S.C. mTOR signaling and molecular adaptations to resistance exercise. Med Sci Sports Exerc. 38:1950-1957, 2006.
Baar, K., Nader, G. and Bodine, S.C. Resistance exercise, muscle loading/unloading and the control of muscle mass. Essays in Biochemistry. 38:1950-1957, 2006.
Kline, W.O., Panaro, F.J., Yang, H., and Bodine, S.C. Rapamycin inhibits the growth and muscle sparing effects of clenbuterol. J. Appl. Physiol. 102: 740-741, 2007. Epub 2006 Oct 26.
Faculty