Mike Wright

Assistant Professor
Ph.D., University of Washington, 2000
Office Phone: (530) 754-4043
E-mail: mewright@ucdavis.edu

Research Interests:
Protein networks controlling growth and differentiation of prostate cancer

Research Synopsis:
My laboratory is reconstructing protein networks based upon changes in protein abundance and post-translational modifications (e.g. phosphorylation, ubiquitination, sumolyation) in response to different biological stimuli using quantitative mass spectrometry methods. We employ a combination of research techniques and tools in the areas of molecular and cellular biology, classical protein biochemistry, and quantitative mass spectrometry to define the composition, activity, and cellular function of proteins and protein machines on a global scale in higher organisms. A major research focus in my laboratory is to define the underlying protein networks that drive the growth and differentiation of both early and late-stage prostate cancer (CaP). We are also interested in identifying new protein biomarkers that aid in the diagnosis, prognosis, and therapeutic treatment of CaP in men.

Selected Publications

Wright, M.E., et al., Identification of androgen-coregulated protein networks from the microsomes of human prostate cancer cells. Genome Biol, 2003. 5(1): p. R4. Abstract.

Wright, M.E., M.J. Tsai, and R. Aebersold, Androgen receptor represses the neuroendocrine transdifferentiation process in prostate cancer cells. Mol Endocrinol, 2003. 17(9): p. 1726-37. Abstract.

Griffin, T.J., et al., Abundance ratio-dependent proteomic analysis by mass spectrometry. Anal Chem, 2003. 75(4): p. 867-74.
Lundgren, D.H., et al., PROTEOME-3D: An Interactive Bioinformatics Tool for Large-Scale Data Exploration and Knowledge Discovery. Mol Cell Proteomics, 2003. 2(11): p. 1164-76. Abstract.

Deborah H. Lundgren, Jimmy Eng, Michael E. Wright, David K. Han. "PROTEOME-3D: An Interactive Bioinformatics Tool for Large-Scale Data Exploration and Knowledge Discovery." Vol.2(11), Molelcular and Cellular Proteomics, October 1164-1176 2003. Abstract.

Martin, D.B., et al., Quantitative proteomic analysis of proteins released by neoplastic prostate epithelium. Cancer Res, 2004. 64(1): p. 347-55. Abstract.

Desiere, F., et al., Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol, 2005. 6(1): p. R9. Abstract.

Wright, M.E., D.K. Han, and R. Aebersold, Mass spectrometry based expression profiling of clinical prostate cancer. Mol Cell Proteomics, 2005. Abstract.

Hwang, SI, Thumar J, Lundgren DH, Rezaul K, Mayya V, Wu L, Eng J, Wright ME, Han DK. Direct cancer tissue proteomics: a method to indentify candidate cancer biomarkers from formalin-fixed paraffin-embedded archival tissues. Oncogene, June 2006. Abstact.