General pediatrics research
Dr. Byrd conducts research on the epidemiology of early school failure, promotion of school readiness, enuresis, uninsured children, adolescent risk behavior, blood lead exposure, ear infections, and asthma.
Dr. Kair conducts clinical research focused on improving maternal and child health through designing and implementing evidence-based interventions aimed at overcoming breastfeeding barriers and disparities.
Dr. Chantry conducts research on infant nutrition, breastfeeding, and term newborn care particularly with regards to the effects of HIV. She studies the risks, benefits, difficulties, and promotion of breastfeeding, home pasteurization of HIV-infected breast milk for women in resource-poor areas, and growth, body composition, and metabolism in HIV-infected children.
Dr. Coulter's research includes the detection of physical abuse injuries, diagnostic studies in physically abused children, and the health status of children placed in protective custody due to abuse and neglect.
Dr. Fernandez y Garcia's research interests include investigating the effects of parental depression on the medical care of infants and children.
Dr. Kuppermann's research interests include the epidemiology of meningococcal disease in children, laboratory evaluation of pediatric trauma patients, radiography of the cervical spine in pediatric trauma, and pediatric diabetic ketoacidosis and risk of cerebral edema.
Dr. Kurzrock's research interests include reconstructive techniques, stem cell biology, and tissue engineering specific to the bladder.
Dr. Li is interested in determining how to best use information technology to put evidence-based pediatrics into practice, and methods to teach medical students and residents to apply the best available evidence to the care of patients. She has also published on the efficacy of various treatments for empyema in childhood, and on the rising incidence of inpatient admissions for pediatric empyema in spite of the pneumococcal vaccine.
Dr. McDonald's research has focused on new approaches to managing spasticity in children with cerebral palsy and the role of exercise in childhood progressive neuromuscular disease. Other areas of interest include energy expenditure during locomotion, qualitative measures of physical activity, pediatric trauma, and spina bifida.
Dr. Pleasure's research focuses on the role of neural stem cells in the generation of oligodendroglia. He also studies how inflammation of white matter contributes to certain autoimmune diseases like multiple sclerosis, cerebral palsy, and several inherited childhood diseases such as adrenoleukodystrophy.
Dr. Romano's research interests include comparative evaluation of health care outcomes, the use of outcomes data to improve the quality and effectiveness of health care, and the role of physicians, nurses, and other professionals in optimizing the quality and safety of health care.
Dr. Shaikh conducts research aimed at improving healthcare quality, specifically with respect to pediatric nutrition. Her research broadly deals with identifying factors that influence physician decision-making with respect to pediatric nutrition, and evaluating health system and telehealth applications (e.g., clinical telemedicine, distance education, internet communication) in improving the quality of clinical care in pediatric obesity.
Daniel Tancredi, Ph.D. - PubMed
Dr. Tancredi's research interests include developing efficient statistical design and analysis plans for observational and experimental clinical research studies, especially studies that involve correlated data, as arise in cluster-randomized trials, longitudinal studies, and survey that use complex probability designs.
Dr. Tarantal's research program primarily centers on fetal diseases and corrective in utero therapies with a focus on stem cell biology and regenerative medicine. Translational activities using the nonhuman primate model includes: (1) gene therapy; (2) cell-based therapies/tissue engineering; (3) fetal/infant models of human congenital and acquired diseases of the blood and kidney; (4) fetal:maternal microchimerism; and (5) in vivo imaging.
Dr. Tarantal's Websites:
- Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases
- Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases
- UC Davis Translational Human Embryonic Stem Cell Shared Research Facility
- Center for Pediatric Stem/Progenitor Cell Translational Research
Birth defects are the leading cause of infant mortality in the United States, accounting for more than 20% of all infant deaths, yet the causes of about 70% of all birth defects are still unknown. My lab is involved in studies of non-Mendelian (multifactorial) birth defects, such as nonsyndromic craniosynostosis, bladder epispadias-exstrophy complex, and cleft lip and/or palate. Our ultimate goal is to identify genes and environmental factors contributing to the risk of these birth defects. Our initial approach involves recruitment and systematic evaluation of a large group of affected families. This allows for unbiased ascertainment of the clinical and epidemiologic characteristics of these defects and their phenotypic variability. Genome-wide linkage studies have been instrumental in elucidating the etiology of numerous single-gene diseases. For multifactorial traits such as most of the birth defects, these methods have proven less successful. Our strategy is to use case-parent trios with birth defects for SNP based association studies on groups of candidate genes or, more recently, using SNP chips for genome-wide coverage. It is important to emphasize that these approaches can be successfully used for genetic analysis of any complex trait, i.e. autism, diabetes, and hypertension. We are happy to collaborate and provide genetic expertise to clinicians and researchers interested in multifactorial human disorders.
My lab is also involved in identification and characterization of genetic syndromes due to defects of the intracellular secretory pathway. We have recently identified and characterized a new autosomal recessive genetic syndrome, Cranio-Lenticulo-Sutural dysplasia (CLSD; OMIM 607812). This syndrome manifests with early onset cataracts, facial dysmorphisms and late closing fontanels. After mapping CLSD to chromosome 14q13 we identified the causative mutation in SEC23A, an integral member of the COPII complex that transports proteins from the endoplasmic reticulum to the Golgi complex. After characterization of a morpholino zebrafish model we are now working on creating transgenic Sec23a deficient mice. This murine model will allow more detailed analysis of the secretory pathway and its role in health and disease. Using classical and reverse genetic approaches we plan to identify and characterize other human disorders caused by defects of the individual components of the secretory pathway.
More information about our clinical and molecular research is available from the Department of Genetics' List of Studies