Pediatric endocrinology research
Nicole Glaser, M.D.
Dr. Glaser's research is focused on pediatric diabetic ketoacidosis (DKA). Specifically, she has been studying the cause and treatment of a serious complication of DKA, cerebral edema. Both animal and human studies utilize MRI technologies to assess brain metabolism, perfusion, and edema formation. In addition, she investigates methods for improving blood glucose control in children with diabetes.
Dennis Styne, M.D.
Dr. Styne conducts clinical research on childhood obesity. Using activity, education, and pharmaceutical therapy, he studies children in his Fit-Kid Weight Management Clinic, evaluating the best methods of assessment and treatment of obesity and its co-morbidities. He also has an outreach program to Northern California Indian Rancherias that combines education for local health care workers and telehealth communication between the UC Davis Medical Center-based children's weight management team and the families. Additional research involves improving therapies for disorders of pubertal development and growth, the effect on traumatic brain injury on hypothalamic pituitary function, and the effects of endocrine disruptors.
Craig Warden, Ph.D.
Dr. Warden uses molecular genetics techniques in mouse models to study the impact of natural genetic variants on obesity and on response to diet and exercise. He has identified a protein that alters levels of hypothalamic alpha-melanocyte stimulating hormone (alpha-MSH), a natural food intake inhibitor. This protein is a potential drug target because inhibitors decrease hunger. He also studies whether some people are genetically programmed to fail to maintain weight loss following gastric bypass surgery.