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Department of Pathology and Laboratory Medicine

Department of Pathology and Laboratory Medicine

Point-of-Care Technologies Center: Center Activities

Mission/Goal

The UC Davis Center will advance public health by developing new POC devices that accelerate diagnosis and treatment of life-threatening bloodstream infections, prepare our nation for future disasters, and enhance patient survival and outcomes through rapid decision making at the bedside in hospitals, during acute care in emergency rooms, and for field rescue when disasters strike. The Center goal is to improve the accessibility, portability, and field robustness of point-of-care (POC) devices for critical care units, emergency rooms, community hospitals, rural areas, and disaster response sites.

Clinical Theme

The overall theme is critical-emergency-disaster care.

POC Technology

The Center will use isothermal loop-mediated amplification (LAMP) technology for rapid multipathogen detection by nucleic acid testing for bacteria and fungi DNA in whole-blood samples.

Project Overview

  • Core 1. The LLNL team will develop a compact user-friendly POC system that uses loop mediated isothermal amplification (LAMP) for simultaneous detection of multiple pathogens (Candida sp., E. Coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae) in human whole-blood samples.
  • Core 2. The core provides a resource for testing the environmental robustness of  POC devices and will produce suitable new POC devices through a series of exploratory projects.
  • Core 3 and 4. Our education and training focus in these cores will support the Center mission, critical-emergency-disaster care, and disseminate information worldwide.  We plan to assess the current diagnostic capabilities of disaster medical assistance teams (DMATs), and also to survey the additional diagnostic tests needed by DMATs for field rescue use, and the robustness criteria for POCT in the field.  Properly equipped teams with environmentally robust POCT will facilitate evidence-based medicine during field rescues.