Ruijun Jeanna Su, M.D., Ph.D. Resident, PGY 4

Medical School:
Guangzhou Medical University, China

Personal Interests:
Swimming, hiking, enjoying literature, art and music

Reason for selecting UC Davis for Residency:
UC Davis provides a good environment and training for residents.


Clinical Interests

  • Hematopathology - lymphoma & leukemia
  • Transplant pathology - hematopoietic stem cell transplant & organ transplant

Research Interests

  • Hematopoietic stem cell & leukemia stem cell
  • Gene therapy of hemophilia A & immune tolerance induction in hemophilia A patients with inhibitors

Publications

Research Articles

Su RJ, Li K, Yang M, Zhang XB, Tsang KS, Fok TF, Li CK, Yuen PMP.  Platelet-derived growth factor enhances ex vivo expansion of megakaryocytic progenitors from human cord blood.  Bone Marrow Transplantation.  2001 May;27 (10):1075-80. PubMed PMID: 11438824.

Su RJ, Zhang XB, Li K, Yang M, Li CK, Fok TF, James AE, Pong H, Yuen PM. Platelet-derived growth factor promotes ex vivo expansion of CD34+ cells from human cord blood and enhances LTC-IC, NOD/SCID repopulating cells and formation of adherent cells. British Journal of Haematology 2002 Jun;117(3):735-46. PubMed PMID: 12028051.

Li K, Lee SM, Su RJ, Zhang XB, Yuen PM, Li CK, Yang M, Tsang KS, James AE, Tse YH, Ng LY, Fok TF. Multipotent neural precursors express neural and hematopoietic factors, and enhance ex vivo expansion of cord blood CD34(+) cells, colony forming units and NOD/SCID-repopulating cells in contact and noncontact cultures. Leukemia. 2005 Jan;19(1):91-7. PubMed PMID: 15496976.

Su RJ, Li K, Zhang XB, Pan Yuen PM, Li CK, James AE, Liu J, Fok TF. Platelet-derived growth factor enhances expansion of umbilical cord blood CD34+ cells in contact with hematopoietic stroma. Stem Cell Development. 2005 Apr;14(2):223-30. PubMed PMID: 15910249.

Su RJ, Epp A, Latchman Y, Bolgiano D, Pipe SW, Josephson NC. Suppression of FVIII inhibitor formation in hemophilic mice by delivery of transgene modified apoptotic fibroblasts. Molecular Therapy. 2010 Jan,18 (1):214-22. PubMed PMID: 19755963.

Su RJ, Epp A, Feng J, Roy J, Latchman Y, Wu X, Josephson NC. Suppression of the Immune Response to FVIII in Hemophilia A Mice by Transgene Modified Tolerogenic Dendritic Cells. Molecular Therapy. 2011 Oct;19(10):1896-904. PubMed PMID: 21772255.

Francis OL, Payne JL, Su RJ, and Payne KJ. Regulator of myeloid differentiation and function: The secret life of Ikaros. World Journal of Biological Chemistry. 2011 Jun 26;2(6):119-25. PubMed PMID: 21765977

Meng X, Neises A, Su RJ, Payne KJ, Ritter L, Gridley DS, Wang J, Sheng M,  Lau H-K W, Baylink DJ  and Zhang XB. Efficient Reprogramming of Human Cord Blood CD34 (+) Cells Into Induced Pluripotent Stem Cells With OCT4 and SOX2 Alone. Molecular Therapy. 2012 Feb;20(2):408-16. PubMed PMID: 22108860.

Meng X*, Su RJ*, Baylink DJ , Neises A, Kiroyan JB, Lee W, Payne  KJ, Gridley DS, Lau H-K W, Li G, Zhang XB. Rapid and Efficient Reprogramming of Human Fetal and Adult Blood CD34+ Cells into Mesenchymal Stem Cells with a single factor. Cell Research 2013 May;23(5):658-72. PubMed PMID: 23478301 *These authors contribute equally in this work.

Su RJ, Yang Y, Nieses A, Payne KJ, Wang J, Wakeland EK, Fang X, Zhang XB. Few de novo Single Nucleotide Variations in Exomes of Human Cord Blood Induced Pluripotent Stem Cells. PLOS One. 2013;8(4):e59908.doi:10.1371/journal.pone.0059908. Epub 2013 Apr 1. PubMed PMID: 23573220.
 
Su RJ, Baylink DJ, Neises A, Meng X, Kiroyan JB, Payne KJ, Duan Y, Tschudy-Seney B, Appleby N, Kearns-Jonker M, Gridley DS, Wang J, Lau KHW, Zhang XB.  Efficient Generation of Integration-Free iPS Cells from Human Adult Peripheral Blood Using BCL-XL Together With Yamanaka Factors. PLOS One. 2013 May 21;8(5):e64496. doi: 10.1371/journal.pone.0064496. PubMed PMID: 23704989.

Benitez A, Weldon AJ, Tatosyan L, Velkuru V, Lee S, Milford TA, Francis OL, Hsu S, Nazeri K, Casiano CM, Schneider R, Gonzalez J, Su RJ, Baez I, Colburn K, Moldovan I, Payne KJ. Differences in mouse and human nonmemory B cell pools. Journal of Immunology. 2014 May 15;192(10):4610-9. doi: 10.4049/jimmunol.1300692. Epub 2014 Apr 9. PubMed PMID: 24719464.

Francis OL, Milford TM, Martinez SR, Baez I, Coats JS, Mayagoitia K, Concepcion KR, Ginelli E, Beldiman C, Benitez A, Weldon AJ, Arogyaswamy K, Shiraz P, Fisher R, Morris CL, Zhang XB, Filippov V, Van Handel B, Ge Z, Song C, Dovat S, Su RJ*, Payne KJ*. A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis. Haematologica. 2015 Nov 26. PubMed PMID: 26611474. *These authors share corresponding authorship in this work.

Milford TM, Su RJ, Francis OL, Baez I, Martinez SR, Coats JS, Weldon AJ, Calderon MN, Nwosu MC, Botimer AR, Suterwala BT, Zhang XB, Morris CL, Weldon DJ, Dovat S, and Payne KJ. TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis. European Journal of Immunology. 2016 Jun 21. doi: 10.1002/eji.201646307. PubMed PMID: 27325567.

Wen W, Zhang JP, Xu J, Su RJ, Neises A, Ji GZ, Yuan W, Cheng T, Zhang XB. Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors. Stem Cell Reports. 2016 Jun 14;6(6):873-84. PubMed PMID: 27161365.

Syed R, Shibata NM, Kharbanda KK, Su RJ, Olson K, Yokoyama A, Rutledge JC, Chmiel KJ, Kim K, Halsted CH, Medici V. Effects of Nonpurified and Choline Supplemented or Nonsupplemented Purified Diets on Hepatic Steatosis and Methionine Metabolism in C3H Mice. Metab Syndr Relat Disord. 2016 May;14(4):202-9. doi: 10.1089/met.2015.0147. Epub 2016 Feb. 16.  PubMed PMID: 26881897.

Medici V, Kieffer DA, Shibata NM, Chima H, Kyoungmi K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda  KK, Olson K; Su RJ; Islam MS;  Syed R; Rutledge JC; Keen CL, Miller AY, Rutledge JC, Halsted CH and LaSalle JM. Wilson Disease: epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics. 2016 Sep 9:0 PubMed PMID: 27611852.

Book Chapters

Su RJ, Nieses A, Zhang XB. Generation of iPS Cells from Human Peripheral Blood Mononuclear Cells Using Episomal Vectors. Methods Mol Biol. 2014 Nov 18. Springer Protocol. ISSN: 1949 – 2448. PMID: 25403468.

Neises A, Su RJ and Zhang XB. Reprogramming of Human Cord Blood CD34+ Cells into Induced MSCs. Hematopoietic Differentiation of Human Pluripotent Stem Cells, SpringerBriefs in Stem Cells, Chapter 7. 2015. DOI 10.1007/978-94-017-7312-6_7, pp91-101.

Su RJ and Chen M. Primary cutaneous T-cell lymphoma, gamma-delta Type. Case Studies in Hematology & Coagulation (2nd edition).

Su RJ and Chen M. T-cell prolymphocytic leukemia. Case Studies in Hematology & Coagulation (2nd edition).

Clinical Case Reports

Su RJ, Jonas BA, Welborn J, Gregg JP, Chen M. Chronic eosinophilic leukemia, NOS with t(5;12) (q31;p13)/ETV6-ACSL6 gene fusion: a novel variant of myeloid proliferative neoplasm with eosinophilia. Human Pathology. 2016 Sept;5:6-9. PubMed PMID: 27458550.

Su RJ, EC Huang, Chen M. Central Nervous System Relapsed B-Lymphoblastic Leukemia with t(9;22)(q34;q11) BCR/ABL1 Mimicking Acute Myeloid Leukemia. Hematopathology. 2016 Sept; 1(2): 108-113.