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Department of Pathology and Laboratory Medicine

Department of Pathology and Laboratory Medicine

Ralph Green, M.D.

Ralph Green, M.D.

Professor

Department of Medical Pathology and Laboratory Medicine
UC Davis Medical Center
PATH Building
4400 V Street
Sacramento, CA 95817

Ph: (916) 734-8078
e-mail

Clinical/Research Interests

Ralph Green is a clinical pathologist, with particular interest in diseases of the blood. Immediate past chair of the department, Dr. Green continues to serve as Medical Director of the UC Davis Health System Medical Diagnostics Outreach Laboratory. He is internationally recognized for his research, which focuses on studying how deprivation or metabolic disruption of B-complex vitamins, iron and other nutritional elements affects the blood, cardiovascular system, nervous system, and the aging process. He has studied the role of nutrient deficiencies in dementia, coronary artery disease, and stroke, as well as other chronic degenerative diseases, including cancer. He has a strong interest in graduate pathology education and was elected to serve on the Council of the Association of Pathology Chairs, chairing the Graduate Medical Education Committee for two terms. He has served as an adviser to numerous Governmental and International Agencies including the National Institutes of Health , U.S. Food and Drug Administration, Centers for Disease Control, and American Heart Association. He served on an expert panel appointed by the Institute of Medicine of the National Academy of Sciences to recommend levels of daily intake for B-vitamins and serves as a consultant to the World Health Organization. Dr Green is on the editorial boards of several scientific journals.

 

Representative Publications

Cheung ATW, Miller JW, Craig SM, To PL, Lin X, Samarron SL, Chen PCY, Zwerdling T, Wun T, Li C-S, Green R. Comparison of real-time microvascular abnormalities in pediatric and adult sickle cell anemia patients. American Journal of Hematology Am J Hematol. Nov;85(11):899-901,2010

Garrod MG, Allen LH, Haan MN, Green R, Miller JW. Transcobalamin C677G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics. European Journal of Clinical Nutrition 64, 503–509, 2010.

Green R: Anemia Resulting from other Nutritional Deficiencies: William’s Hematology, Chapter 43, McGraw-Hill 8th ed, 2010, p 607-612, 2010

Green R: Folate, Cobalamin, and Megaloblastic Anemias: William’s Hematology, Chapter 41, McGraw-Hill 8th ed 2010, p 533-363, 2010.

Howell L, Chen CY, Joad J, Green R, Callahan E, Bonham A: Addressing the Issues and Challenges of Non-Tenure Track Research Faculty at the UCDavis School of Medicine. Academic Medicine: 85;6, 1041-1047, 2010.

Green R: Ins and outs of cellular cobalamin transport. Blood. 115:8 1476-1477, 2010

Green R. Is it Time for B12 Fortification? What are the Questions?: Am J Clin Nutr Vol 89(suppl): S712-S717, 2009.

Miller J, Garrod M, Allen L, Haan M, Green R: Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate. American Journal of Clinical Nutrition 90: 1586-1592, 2009.

Reitz C, Tang M-X, Miller J, Green R. Plasma homocysteine and risk of mild cognitive impairment. Dementia and Geriatric Cognitive Disorders27:11-7, 2009. PMID: 19088473.

Green R. Indicators for Assessing folate and Vitamin B12 Status and for Monitoring the Efficacy of Intervention Strategies. Food and Nutrition Bulletin, Vol 29, No 2 (Suppl) S52-S63, 2008.

Miller JW, Borowsky AD, Marple TC, McGoldrick ET, Dillard-Telm L, Young L JT, and Green R. Folate, DNA methylation, and mouse models of breast tumorigenesis. Nutrition Reviews Vol. 66 (Suppl.1) S56-S61, 2008.

Pront R, Margalioth E, Green R, Eldar-Geva T, Maimoni Z, Zimran A, Elstein D. Prevalence of Low Serum Cobalamin in Infertile Couples. Andrologia, Vol 41, ( 1): p 46-50, 2008.

Garrod MG, Green R, Allen LH, Mungas DM, Jagust WJ, Haan MN, Miller JW. Fraction of Total Plasma Vitamin B12 Bound to Transcobalamin Correlates with Cognitive Function in Elderly Latinos with Depressive Symptoms. Clinical Chemistry 54:7 1210-1217, 2008.

Green R, Miller JW. Vitamin B12. In: Zempleni J, Rucker RB, Eds. Handbook of Vitamins. Boca Raton, FL: Taylor and Francis, pp. 413-457, 2007.

Haan MN, Miller JW, Aiello AE, Whitmer RA, Jagust WJ, Mungas DM, Allen LH, Green R. Homocysteine, B vitamins and incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging. American Journal of Clinical Nutrition. 85(2): 511-517, 2007.

Luchsinger JA, Tang MX, Miller J, Green R, Mayeux R. Relation of Higher Folate Intake to Lower Risk of Alzheimer Disease in the Elderly Arch. Neurol. 64(1): 86-92, 2007.

Luchsinger JA, Tang MX, Miller J, Green R, Mehta, PD, Mayeux R. Relation of Plasma Homocysteine to Plasma Amyloid Beta levels. Neurochem. Res. 32: 775-781, 2007.

Miller JW, Garrod MG, Rockwood AL, Kushnir MM, Allen LH, Haan MN, Green R. Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency. Clin. Chem, 52: 278-85, 2006.

Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Hammock B, Roth JR, Anderson PJ: Specific 14C-labeling of cobalamin and accelerator mass spectrometry underlie a quantitative test for B12 absorption in humans. Proceedings of the National Academy of Science of the United States of America, 103(15): 5694-5699, 2006.

 Green R: Protean H pylori: Perhaps “Pernicious” Too? (Editorial) Blood 107(4): 1247, 2006.