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Department of Pathology and Laboratory Medicine

Department of Pathology and Laboratory Medicine

Mingyi Chen, M.D., Ph.D.

Mingyi Chen, M.D., Ph.D.

Associate Professor

Department of Pathology and Laboratory Medicine
UC Davis Health System
PATH Building
4400 V Street
Sacramento, CA 95817

Ph: (916) 734-3587
Pager: (916) 816-0202
e-mail

Clinical Interests

  • Hematopathology - lymphoma, leukemia, flow cytometry, bone marrow transplant and diagnostic molecular pathology
  • Pulmonary pathology and GI-liver pathology

 

Research Interests

  • Atherosclerosis, thrombosis, vascular biology, and lipid metabolism
  • Molecular pathogenesis of lymphoma and leukemia, tumor immunology and GVHD
  • Viral infections and cancergenesis

 

Brief Biography

  • Medical School: Peking University Health Science Center, China
  • Graduate school: Ph.D. in Pharmacology, Kyoto University, Japan
  • Postdoctoral fellowship: Howard Hughes Medical Institute/UCLA
  • Internship: University of California, San Diego
  • Residency: Loma Linda University Medical Center
  • Fellowship: Hematopathology, City of Hope National Medical Center
  •  

Board Certification

  • Diplomate of the American Board of Pathology (Anatomic and clinical pathology) (08/2009)
  • Diplomate of the American Board of Pathology in Hematology (10/2010)

 

Representative Publications 

  1. Zhang H, Li Y, Lin TY, Xiao K, Haddad AS, Henderson PT, Jonas BA, Chen M, Xiao W, Liu R, Lam KS, Pan CX. Nanomicelle Formulation Modifies the Pharmacokinetic Profiles and Cardiac toxicity of Daunorubicin. Nanomedicine (Lond). 2014 Mar 17.
  2. Sonu R, Chen M. Primary lymphoproliferative disorders of the liver: a review and pragmatic guide to diagnosis. ASCP HEMATOPATHOLOGY (2014) NO 1. HP 14-1 (H-364), 49(1): 2167-2245.
  3. Bouchlaka M Sckisel G, Chen M, Mirsoan A, Zamora A, Monjazeb A, Longo D, Blazar BR, Taub DD,  Murphy WJ.. Aging predisposes to acute inflammatory induced pathology following tumor immunotherapy. J Exp Med. 2013 Oct 21;210(11):2223-37.
  4. Chen M, Abedi M. Atypical lymphocytosis and cold agglutinin hemolytic anemia associated with monoclonal gammopathy in HIV-infected patient with marrow involvement by diffuse large B-cell lymphoma. Blood, 2013 Nov 28;122(23):3711
  5. Chen M, Krishnamurthy A, Mohamed AR, Green R. Hematological disorders following gastric bypass surgery: emerging concepts of the interplay between nutritional deficiency and inflammation. Biomed Res Int. 2013;2013:205467.
  6. Chen M, Green R. Circulating plasma cells with Russell bodies in osteroslerotic myeloma. Blood 2013 July 11; 122:160.
  7. Chen M, Olson K. Colonic graft-versus-host disease (GVHD) manifesting as eosinophilic colitis following autologous hematopoietic stem cell transplantation. Blood. 2013 May 16;121(20):4020.
  8. Sungur CM, Tang-Feldman YJ, Ames E, Alvarez M, Chen M, Longo DL, Pomeroy C, Murphy WJ. Murine natural killer cell licensing and regulation by T regulatory cells in viral responses. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7401-6.
  9. Chen M, Van Ness M, Guo Y, Gregg J. Molecular pathology of pancreatic neuroendocrine tumors. J Gastrointest Oncol. 2012 Sep;3(3):182-8.
  10. Khojeini EV, Durham BH, and Chen M. Mantle Cell Lymphoma and Involvement of the Orbit and Ocular Adnexa. Case Reports in Pathology. 2013 581856-62.
  11. Van Ness M, Gregg J, Wang J, Chen M. Genetics and molecular pathology of gastric malignancy: Development of targeted therapies in the era of personalized medicine. J Gastrointest Oncol. 2012 Sep;3(3):243-51.
  12. Sun K, Hsiao HH, Li M, Ames E, Bouchlaka M, Welniak LA, Hagino T, Jagdeo J, Pai CC, Chen M, Blazar BR, Abedi M, Murphy WJ. INF-gamma receptor-deficient donor t cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation. J Immunol. 2012 Aug 15;189(4):2033-42.
  13. Bautista-Quach MA, Ake CD, Chen M, Wang J.Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features. J Gastrointest Oncol. 2012 Sep;3(3):209-25.
  14. Afify A, Das S, Chen M. Two Smalls in One: co-incident small cell carcinoma and small lymphocytic lymphoma in a lymph node diagnosed by fine-needle aspiration biopsy. CytoJournal 2012, 9(5):1-5.
  15. Sonu R, Song J, Chen M. Extramedullary hematopoiesis associated with myeloproliferative neoplasm manifesting as pleural effusion: Case report and review of literature. J Hematopathol (24 May 2012), pp. 1-7.
  16. Yang Y, Batth SS, Chen M, Borys D, Phan H. Enteropathy-associated T cell lymphoma presenting with acute abdominal syndrome: a case report and review of literature. J Gastrointest Surg. 2012 Jul;16(7):1446-9.
  17. Sun K, Alvarez M, Ames E, Barao I, Chen M, Longo DL, Redelman D, Murphy WJ. Mouse NK Cell-Mediated Rejection of Bone Marrow Allografts Exhibits Patterns Consistent with Ly49 Subset Licensing. Blood. 2012 Feb 9;119(6):1590-8.
  18. Sonu R, Gregg J, and Chen M. Splenic Marginal Zone Lymphoma with Isolated t(8;14)(q24.1;q32)/MYC Rearrangement. J Hematopathol (2012) 5 (3) 141-147.
  19. Chen M, Argawal R., Nasseri-Nik N, Sloman A, Weiss LM. Indeterminate cell tumor of spleen. Human Pathology 2012 Feb;43(2):307-11.
  20. Chen M. Neoplasms of dendritic cells: related cell origins and diagnostic markers: fibroblastic reticulum cells and fibroblastic reticulum cell tumors show several immunophenotypic profiles-Reply. Human Pathology. (2012) Sep;43(9):1531-2.
  21. Chen M, Kim Y, Huang Q, Chang K, Gaal K, Weiss LM. Acute myeloid leukemia with an unusual histologic pattern mimicking metastatic neoplasm in bone marrow: a diagnostic pitfall. J Hematopathol (2011) 4 (2):117–122.
  22. Chen M, Wang J. Gaucher disease: review of the literature. Arch Pathol Lab Med. 2008 May;132(5):851-3.
  23. Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest. 2007 Aug;117(8):2337-46.
  24. Chen M, Bradley MN, Beaven SW, Tontonoz P. Phosphorylation of the liver X receptors. FEBS Lett. 2006 Sep 4;580(20):4835-41.
  25. Wolf P, Chen M. Tribute to Dr. Donald Moss’s contribution to clinical pathology and clinical enzymology. Acta Clinica Chimica. 2006 369 106-107.
  26. Chen M, Beaven S, Tontonoz P. Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha. J Lipid Res. 2005 Dec;46(12):2570-9.
  27. Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab. 2005 Mar;1(3):201-13.
  28. Chen M, Sawamura T. Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1). J Mol Cell Cardiol. 2005 Sep;39(3):553-61.
  29. Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P. Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 2005 Aug 12;280(32):29256-62.
  30. Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P. The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Mol Cell Biol. 2003 Mar;23(6):2182-91.
  31. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9.
  32. Nakagawa T, Yasuda T, Hoshikawa H, Shimizu M, Kakinuma T, Chen M, Masaki T, Nakamura T, Sawamura T. LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt. Biochem Biophys Res Commun. 2002 Nov 22;299(1):91-7.
  33. Nakagawa T, Akagi M, Hoshikawa H, Chen M, Yasuda T, Mukai S, Ohsawa K, Masaki T, Nakamura T, Sawamura T. Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis. Arthritis Rheum. 2002 Sep;46(9):2486-94.
  34. Chen M, Masaki T, Sawamura T. LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther. 2002 Jul;95(1):89-100.
  35. Chen M, Nagase M, Fujita T, Narumiya S, Masaki T, Sawamura T. Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE. Biochem Biophys Res Commun. 2001 Oct 5;287(4):962-8.
  36. Chen M, Inoue K, Narumiya S, Masaki T, Sawamura T. Requirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein. FEBS Lett. 2001 Jun 22;499(3):215-9.
  37. Chen M, Narumiya S, Masaki T, Sawamura T. Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding. Biochem J. 2001 Apr 15;355(Pt 2):289-96.
  38. Chen M, Kakutani M, Naruko T, Ueda M, Narumiya S, Masaki T, Sawamura T. Activation-dependent surface expression of LOX-1 in human platelets. Biochem Biophys Res Commun. 2001 Mar 23;282(1):153-8
  39. Chen M, Kakutani M, Minami M, Kataoka H, Kume N, Narumiya S, Kita T, Masaki T, Sawamura T. Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol. 2000 Apr;20(4):1107-15
  40. Chen M, Sawamura T. Northern blot analysis to quantify gene expression in vascular diseases. Methods Mol Med. 1999;30:181-8.
  41. Aoyama T, Chen M, Fujiwara H, Masaki T, Sawamura T. LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells. FEBS Lett. 2000 Feb 11;467(2-3):217-20.


Book Chapters

  1. Chen MY, Smared T and Wang J. (2013). Diagnosis of Primary Gastrointestinal Lymphomas and Mimics. In iconceptpress.
  2. Chen,MY and Chang K. (2011) T-cell prolymphocytic leukemia (T-PLL). In “Case Studies in Hematology and Coagulation” ASCP Press.
  3. Chen,MY (2010). “Molecular biology of glycogen storage diseases”. In Molecular Pathology of Liver Diseases. P.S. Monga. eds. Springer’s MOLECULAR PATHOLOGY series. Philip T. Cagle, editor.
  4. Chen,MY and Sawamura,T. (2001) LOX-1, a potential inflammatory mediators in atherosclerosis. In Inflammatory and Infectious Basis of Atherosclerosis. Mehta, J.L. eds. Birkhäuser Verlag press AG, Switzerland.
  5. Sawamura T., Chen MY, and Masaki T (1998) LOX-1, an endothelial receptor for Oxidized LDL. In Lipoprotein Metabolism and Atherogenesis. Kita, T. eds. Springer Press.