Professor

• University of Alberta, Canada, BS (Hons.), 1984-1987, Physiology
• University of Alberta, Canada, MS, 1987-1988, Neuroscience
• University of Alberta, Canada, PhD, 1988-1991, Neuroscience

• 1988-1990  Visiting Student, Laboratory of Biophysics, NINDS, National Institutes of Health at Marine Biological Laboratory, Woods Hole, MA
• 1991-1992  Postdoctoral Research Fellow, Laboratory of Dr. Robert French, Department of Medical Physiology, University of Calgary, Alberta, Canada
• 1992-1994  Postdoctoral Research Fellow, Laboratory of Dr. Terry Crow, Department of Neurobiology, University of Texas Medical School at Houston
• 1994  Grass Foundation Research Fellow, Marine Biological Laboratory, Woods Hole, MA
• 1994-1997  Postdoctoral Research Fellow- Laboratory of Dr. P. Gillespie, Department of Physiology, Johns Hopkins University School of Medicine
• 1996-present  Visiting Scientist, Marine Biological Laboratory, Woods Hole, MA
• 1997-2000  Assistant Professor, Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati
• 2000-2004  Associate Professor, Department of Otolaryngology, Center for Neuroscience, University of California, Davis
• 2004-present  Professor, Department of Otolaryngology, Center for Neuroscience, University of California, Davis
• 2002-2006  IFCN6 (Now AUD) Study Section NIH/NIDCD
• 2001-present  Integrative Neuroscience & Behavior Review Group National Science Foundation (Ad-Hoc)

• Biophysical Society, Society for Neuroscience, Association for Research in Otolaryngology (ARO).

• 1988 American Society for Cell Biology Award for Research Fellowship, Marine Biological Laboratory, Woods Hole, MA
• 1989  Potters' Research Fellowship, Marine Biological Laboratory, Woods Hole, MA
• 1994  Grass Foundation Research Fellowship, Marine Biological Laboratory, Woods Hole, MA
• 1999  Josiah Macy Faculty Research Fellowship in Neuroscience, Marine Biological Laboratory, Woods Hole, MA

1.  Stockbridge, N. and Yamoah, E. N. 1990. Excitability changes in the Crustacean motor axon following activity. Journal of Mathematical Biology. 18:487-499.

2.  Alkon, D. L., Ikeno, H., Dworkin, J., McPhie, D. L., Olds. J. L., Lederhendler, I., Matzel, L., Schreurs, B. G., Kuzirian, A., Collin, C., Yamoah, E. N. 1990. Contraction of neuronal branching volume: an anatomic correlate of Pavlovian conditioning. Proceedings of the National Academy of Sciences U. S. A. 87:1611-1614.

3.  Lederhendler, I., Rene, E., Yamoah, E. N. & Matzel, L. D. 1990. Outgrowths from Hermissenda photoreceptor somata are associated with activation of protein kinase C. Brain Research. 534:195-200.
4.  Yamoah, E. N. & Crow, T. 1994. Two components of calcium currents in the soma of photoreceptors of Hermissenda. Journal of Neurophysiology. 72: 1327-1336.

5.  Yamoah, E. N., Kuzirian, A. & Sanchez-Andres, J. V. 1994. Calcium current and inactivation in identified neurons in Hermissenda. Journal of Neurophysiology. 72: 2198-2207.

6.  Yamoah, E. N. & Kuzirian, A. 1994. Effects of GABA on outward currents in Hermissenda photoreceptors. Biological Bulletin. 187:265-266.

7.  Yamoah, E. N. & Smith, P. J. S. 1994. Second messenger modulation of steady-state calcium efflux in Aplysia bag cells. Biological Bulletin. 187:270.


8.  Yamoah, E. N. & Crow, T. 1995. Evidence for the contribution of ICa in serotonergic modulation of IK,Ca. Journal of Neurophysiology. 74: 1349-1354.

9.  Yamoah, E. N. & Crow, T. 1995. Protein kinase and G-protein regulation of Ca2+ currents in Hermissenda photoreceptors by 5-HT and GABA. Journal of Neuroscience. 16: 4799-4809.

10.  Yamoah, E. N. & Gillespie, P.G. 1996. Phosphate analogs block adaptation in hair cells by inhibiting adaptation-motor force production. Neuron. 17: 523-533.

11.  Zhao, Y., Yamoah, E.N. & Gillespie, P. G. 1996. Regulation of the hair cell's tip-link and restoration of mechanoelectrical transduction following Ca2+-chelator treatment. Proceedings of National Academy of Science. 94: 15469-15474.

12.  Yamoah, E. N. 1997. Potassium currents in pre-synaptic hair cells of Hermissenda. Biophysical Journal. 72: 193-203.

13.  Yamoah, E. N., E. A Lumpkin, R. A. Dumont, P. J. S. Smith, A. J. Hudspeth, & Gillespie, P.G. 1998. Plasma-Membrane Ca-ATPase extrudes Ca2+ from hair cell stereocilia. Journal of Neuroscience 18: 610-624.

14.  Yamoah, E. N., Matzel, L. & Crow, T. 1998. Expression of different types of inward rectifier currents confers specificity in light and dark response properties of type A and B photoreceptors of Hermissenda. Journal of Neuroscience 18:65501-6511.

15.  Kozel, P. J., R. A Friedman, L. C. Erway, E. N. Yamoah, L. H. Liu, T. Riddle, J. J. Duffy, T. Doetschman, M. L. Miller, E. L. Cardell & Shull, G. E.1998. Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2* Journal of Biological Chemistry. 273:18693-18696.

16.  Flagella, M., L. L. Clarke, M, L. Miller, L. C. Erway, R. A. Gianella, J. Kramer, J. J. Duffy, T. Doetschman, J. N. Lorenz, E. N. Yamoah, E. L. Cardell, & Shull G. E. 1999. Mice lacking the basolateral Na+/K+2Cl- cotransporter have impared intestinal chloride secretion and are profoundly deaf. Journal of Biological Chemistry 274: 26946-26955.

17.  Rodriguez-Contreras, A. and Yamoah E.N. 2001 Direct measurement of single Ca2+ channels in bullfrog hair cells reveals two distinct Ca2+ channel types. Journal of Physiology 534:669-689.

18.  Rodriguez-Contreras, A., W. Nonner and Yamoah E.N. 2002 Calcium transport properties and determinants of anomalous mole fraction effects of single voltage-gated calcium channels in hair cells. Journal of Physiology 538:729-745.

19.  Vázquez, A-E and Yamoah E.N. 2002. Mechanisms of hair cell mechanoelectrical transduction: An Update. Curr. Opin. in Otolaryngol. & Head and Neck Surgery. 10: 403-406.

20.  Xu Y-F, Chiamvimonvat, N. Vázquez, A-E., Akunuru, S, Ratner, N. and Yamoah, E.N. 2002. Gene-Targeted Deletion of Neurofibromin Enhances the Expression of a Transient outward K+ Current in Schwann Cells: A Protein Kinase A-Mediated Mechanism. Journal of Neuroscience 22(21):9194-9202.

21.  Tamse C.T and Yamoah, E. N. 2002. Elementary Properties of Axonal Calcium Currents in Type B Photoreceptors in Hermissenda crassicornis. Journal of Neuroscience 22(24): 10533-10538

22.  Song, H., L. Nie, A. Rodriguez-Contreras, Z-H. Sheng and Yamoah E.N. 2003 Functional interaction of auxiliary subunits and synaptic proteins with the Ca2+ channel (CaV1.3) may impart hair cell-specific Ca2+ current properties. Journal of Neurophysiology 89: 1143-1149.

23.  Tamse C.T., Y. Xu, H. Song, L. Nie and Yamoah E.N. 2003. Presynaptic Mechanisms for Associative Conditioning in Hermissenda May be defined by Protein Kinase A-Mediated Modulation of Ca2+ current. Journal of Neurophysiology 89:1718-1726.

24.  Rodríguez-Contreras, A. and Yamoah E.N. 2003. Effects of permeant ion concentrations on the gating of L-type Ca2+ channels in saccular hair cells. Biophysical Journal 84(5): 3457-3469

25.  Xu, Y., D. Tuteja, Z. Zhang, J. Rodriguez, L. Nie, H. Tuxson, N. Young, K. A.. Glatter, A. E. Vázquez, E. N. Yamoah, and N. Chiamvimonvat. 2003. A novel small conductance, Ca2+-activated K+ channel in human and mouse hearts: Roles in cardiac repolarization. Journal of Biological Chemistry. 278: 49085-49094.

26.  Nie, L, H. Song, M. F. Chen, N. Chiamvimonvat, K. Beisel, Yamoah, E.N, A. E. Vázquez. 2003. Cloning And Expression of A Small Conductance Ca++-Activated K+ Channel, SK2, From The Mouse Cochlea: Co-expression with Acetylcholine ?9/?10 Receptors. Journal of Neurophysiology 91: 1536-1544.

27.  Si, F, H. Brodie, P. G. Gillespie A. E. Vazquez and Yamoah, E.N. 2003. Developmental assembly of transduction apparatus in the chick basilar papilla. Journal of Neuroscience 23: 10815-10826.

28.  Dou, H, Yoon Namkung, Hanqi Chu, Emma Lou Cardell, Hee-Sup Shin, and Yamoah, E. N. 2004 Null Mutation of (?)1D Ca2+ Channel Gene Results in Deafness but no Vestibular Defect in Mice. JARO 5: 215-226.

29.  Steyger, P.S., Fekete, D.M., Heller, S., Schacht, J. and Yamoah, E.N. (2004) Research trends in cochlear development, physiology, dysfunction and bio-medical interventions

The Volta Review, Volume 104, Number 3.

30.  Casimiro, MC, Knollmann BC, Yamoah, EN, Nie, L., Vary JC, Surenko, S, Greene, AE, Grinberg, A, Huang, SP, Ebert, SN, and Pfeifer, K. (2004) Targeted point mutagenesis of mouse Kcnq1: Phenotypic analysis of mice with point mutations that cause Romano-Ward syndrome in humans. Genomics 84: 555-564.

31.  Molina, A.J.A, Verzi, M.P, Birnbaum, A.D, Yamoah, E. N, Hammar, K, Smith, P.J.S and Malchol, R.P. 2004 Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal. Journal of Physiology. 530.3: 639-657.

32.  Nie, L. Feng, W. Diaz, R. Gratton, M. A. Doyle, K.J, and Yamoah, E. N. (2005) Functional consequences of polyamine inhibition by DFMO: Cellular mechanisms for DFMO-mediated ototoxicity. Journal of Biological Chemistry. 280: 15097-15102.

33.  Yamoah, E.N. Levic. S. Redell, J. B, and Crow, T. (2005) Inhibition of Csp24 Expression Blocks the Reductionin IA Produced by One-Trial In Vitro Conditioning of Hermissenda. Journal of Neuroscience. In press.

34.  Florea AM, Yamoah EN, Dopp E. (2005). Intracellular calcium disturbances induced by arsenic and its methylated derivatives in relation to genomic damage and apoptosis induction: a mini-review Environ Health Perspect: doi:10.1289/ehp.7634. [Online 10 February 2005]

http://ehp.niehs.nih.gov/docs/2005/7634/abstract.html.

35.  Nie, L. Mu, K.J, Feng, W, Gratton, M.A and Yamoah, E.N. (2005) Expression and Functional Phenotype of Mouse ether-a-go-go-related gene K+ Channels in the Inner Ear: Potential role in K+ Regulation in the Inner Ear. Submitted.

36.  Hunt DL, Yamoah EN, Shull G. Krubitzer, L. Multisensory plasticity in congenitally deaf mice: How are cortical areas functionally specified. Submitted.

Ebenezer Yamoah and members of his laboratory are interested in how hearing happens, and how/why we develop age-induced hearing loss. Do to this, Dr. Yamoah studies the functional mechanisms of hair cell transduction and generation of the endocochlear potential in the inner ear that allow hair cells to respond to mechanical movements as minute as the width of a hydrogen atom. They employ techniques ranging from molecular biology, biochemistry, to functional electrophysiology. The goals of the laboratory are to delineate and improve our understanding of the genetics and cellular mechanisms of congenital hearing loss, and how malfunction of hair cells, and reduction in the endocochlear potential lead to hearing loss associated with aging, as well as deafness.

In addition, a fraction of efforts in the laboratory is to understand the mechanisms of short- and long-term neuronal plasticity associated with behavior changes. Here, they use an invertebrate model for learning and memory (Hermissenda crassicornis) to address the elementary properties and changes that ensue in neurons during and after memory acquisition.