Steve P. Tinling, Ph.D.
Dr. Tinling serves as co-investigator with Dr. Brodie for research related to understanding the underlying mechanisms of labyrinthitis ossificans. Additionally, he serves as the Director of Research for the Otolaryngology Research Laboratories. In this capacity he assists and participates in the research efforts of the other departmental faculty members conducting research at the Davis laboratories. He also provides scientific direction and technical assistance to residents on their research rotations in the lab as well as training volunteer medical and undergraduate students. Dr. Tinling manages the laboratory facilities and directs the Laboratory Safety program and ensures laboratory compliance with all other university related issues. He is developing his own the research efforts related to labyrinthitis ossificans and cholesteatoma. Dr. Tinling joined the department in 1982 as the research associate for the former chairman, Dr. Richard Chole. Dr. Tinling has a master's degree in parasitology and electron microscopy and Ph.D. in comparative pathology. Outside of work Dr. Tinling is a naturalist with a passion for backpacking and fishing. He is an avid golfer but also enjoys more cerebral pursuits such as chess and computer mystery games and enjoying the complexities of baroque music.
- California State University, Chico, 09/69 — 06/73, BA degree, Biological Sciences
- California State University, Chico, 1973 – BA Biological Sciences; 1975 – MA Parasitology and Electron Microscopy
- Tulane University, New Orleans, 9/75 — 6/76
- University of California, Davis, 2003 – Comparative Pathology
Microscopy Society of America
Association for Research in Otolaryngology
Si, F., S. L. Ilie, S. P. Tinling and H. A. Brodie. Middle ear therapy with L-NAME lowers the cochlear damage by meningogenic labyrinthitis ossificans in gerbils. (In preparation)
Ge, N. N., S. P. Tinling and H. A. Brodie. Long-term hearing loss in gerbils with bacterial meningitis treated with superoxide dismutase. Otology Neurotology (In preparation)
Tinling, S. P. and R. A. Chole. Gerbilline cholesteatoma development II. Temporal histopathologic changes in the tympanic membrane and middle ear. Otolaryngol Head Neck Surg. (IN PRESS)
Tinling, S. P. and R. A. Chole. Gerbilline cholesteatoma development III. Increased proliferation index of basal keratinocytes of the tympanic membrane and external ear canal. Otolaryngol Head Neck Surg. (IN PRESS)
Tinling SP, Chole RA. Gerbilline cholesteatoma development Part I: Epithelial migration pattern and rate on the gerbil tympanic membrane: Comparisons with human and guinea pig. Otolaryngol Head Neck Surg. 2006 May;134(5):788-93.
Yeung AH, Tinling SP, Brodie HA. Inhibition of post-meningitic cochlear injury with cerebrospinal fluid irrigation. Otolaryngol Head Neck Surg. 2006 Feb;134(2):214-24.
Barry PA, Lockridge KM, Salamat S, Tinling SP, Yue Y, Zhou SS, Gospe SM Jr, Britt WJ, Tarantal AF. Nonhuman primate models of intrauterine cytomegalovirus infection. ILAR J. 2006;47(1):49-64.
Aminpour S, Tinling SP, Brodie HA. Role of tumor necrosis factor-alpha in sensorineural hearing loss after bacterial meningitis. Otol Neurotol. 2005 Jul;26(4):602-9.
Tinling SP, Nabili V, Brodie HA. Fine structure histopathology of labyrinthitis ossificans in the gerbil model. Ann Otol Rhinol Laryngol. 2005 Feb;114(2):161-6.
Ge NN, Brodie SA, Tinling SP, Brodie HA. The effects of superoxide dismutase in gerbils with bacterial meningitis. Otolaryngol Head Neck Surg. 2004 Nov;131(5):563-72.
Tinling SP, Giberson RT, Kullar RS. Microwave exposure increases bone demineralization rate independent of temperature. J Microsc. 2004 Sep;215(Pt 3):230-5.
Smith MC, Tinling S, Doyle KJ. Difluoromethylornithine-induced reversible hearing loss across a wide frequency range. Laryngoscope. 2004 Jun;114(6):1113-7.
Tinling SP, Colton J, Brodie HA. Location and timing of initial osteoid deposition in postmeningitic labyrinthitis ossificans determined by multiple fluorescent labels. Laryngoscope. 2004 Apr;114(4):675-80.
Kim HJ, Tinling SP, Chole RA. Increased proliferation and migration of epithelium in advancing experimental cholesteatomas. Otol Neurotol. 2002 Nov;23(6):840-4.
Kim HJ, Tinling SP, Chole RA. Expression patterns of cytokeratins in cholesteatomas: evidence of increased migration and proliferation.
J Korean Med Sci. 2002 Jun;17(3):381-8.
Kim HJ, Tinling SP, Chole RA. Expression patterns of cytokeratins in retraction pocket cholesteatomas. Laryngoscope. 2001 Jun;111(6):1032-6.
Nabili V, Brodie HA, Neverov NI, Tinling SP. Chronology of labyrinthitis ossificans induced by Streptococcus pneumoniae meningitis.
Laryngoscope. 1999 Jun;109(6):931-5.
Chole RA, Tinling SP, Leverentz E, McGinn MD. Inhibition of nitric oxide synthase blocks osteoclastic bone resorption in adaptive bone modeling.
Acta Otolaryngol. 1998 Sep;118(5):705-11.
Chole RA, Tinling SP. Adaptive bone modeling in the middle ear is substance-P dependent. Am J Otol. 1998 Jul;19(4):521-4.
Demaree, Jr., R. S., R. L. Chrichfield and S. P. Tinling. Oschmarinella macrorchis sp. n. (Digenea: Campulidae) from the liver sinuses of a Beaked Whale, Mesoplodon stejnegeri (Cetacea: Ziphiidae). Journal of the Helminthological Society of Washington 1997 64(2):183-187,
Chole RA, Brummett RE, Tinling SP. Safety of silver oxide-impregnated silastic tympanostomy tubes. Am J Otol. 1995 Nov;16(6):722-4.
Chole RA, Faddis BT, Tinling SP. In vivo inhibition of localized bone resorption by human recombinant interleukin-1 receptor antagonist. J Bone Miner Res. 1995 Feb;10(2):281-4.
Chole RA, Tinling SP, Faddis BT. Human recombinant interleukin-1 receptor antagonist blocks bone resorption induced by interleukin-1 beta but not interleukin-1 alpha. Calcif Tissue Int. 1994 Jul;55(1):12-5.
Chole RA, Tinling SP. Bone lining cells of the mammalian cochlea.
Hear Res. 1994 May;75(1-2):233-43.
Tinling SP, Chole RA. Apical cochlear nerve exposed to perilymph in the gerbil and rat. Hear Res. 1994 Mar;73(2):203-8.
Chole, R.A. and S.P. Tinling. Inflammatory disease of the middle ear and their sequelae; Epidermoid Cholesteatoma in: The Pathology of the Ear. I. Friedmann and W. Arnold, Eds. Churchill Livingstone, United Kingdom, 1993.
Senders CW, Tinling SP. The intrinsic response of the cricoid cartilage to vertical division.Int J Pediatr Otorhinolaryngol. 1993 Dec;28(1):33-9.
Richardson AC, Tinling SP, Chole RA. Risedronate activity in the fetal and neonatal mouse. Otolaryngol Head Neck Surg. 1993 Oct;109(4):623-33.
Chole RA, Tinling SP. Incomplete coverage of mammalian bone matrix by lining cells. Ann Otol Rhinol Laryngol. 1993 Jul;102(7):543-50.
Wolfman DE, Tinling SP. Systemic osteoclast activation by localized pressure.
Arch Otolaryngol Head Neck Surg. 1993 Feb;119(2):165-8.
Tinling, S.P. Spontaneous cholesteatoma in gerbils: preliminary observations. Proceedings, Third International Conference on Cholesteatoma and Mastoid Surgery, Copenhagen, Denmark, June 5-9, 1988. Eds., M. Tos, J. Thomsen and E. Pietersen. Kugler and Ghedini Publications, Amsterdam, pp. 43-47, 1989.
Chole RA, Tinling SP. Fine morphology of bony dysplasia of the murine ear: comparisons with otosclerosis. Am J Otolaryngol. 1987 Sep-Oct;8(5):325-31.
McGinn MD, Chole RA, Tinling SP. Bone resorption induced by middle-ear implants. Arch Otolaryngol Head Neck Surg. 1986 Jun;112(6):635-41.
Chole RA, McGinn MD, Tinling SP. Pressure-induced bone resorption in the middle ear. Ann Otol Rhinol Laryngol. 1985 Mar-Apr;94(2 Pt 1):165-70.
Chole RA, Tinling SP. Basal lamina breaks in the histogenesis of cholesteatoma.
Laryngoscope. 1985 Mar;95(3):270-5.
Chole, R. A. and S. P. Tinling. Autoradiographic studies of mineral transport from regions of bone resorption in experimental cholesteatoma. Ed., E. Myers. New Dimensions in Otorhinolaryngology-Head and Neck Surgery, Vol. 2, 1985.
Tinling SP, Cardinet GH 3rd, Blythe LL, Cohen M, Vonderfecht SL. A light and electron microscopic study of sarcocysts in a horse. J Parasitol. 1980 Jun;66(3):458-65.
Miller, E. S., Demaree, Jr, R. S. and S. P. Tinling. Hematozoa of passeriform birds from Eagle Lake, California. Proceedings of the Helminthological Society of Washington. 45(2):266-268, 1978.
Director of Research for the Otolaryngology Research Laboratories
|Department of Otolaryngology - Head and Neck Surgery|
|2521 Stockton Blvd., Suite 7200
Sacramento, CA 95817
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